DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4611 and ptcd1

DIOPT Version :9

Sequence 1:	NP_647949.1	Gene:	CG4611 / 38601	FlyBaseID:	FBgn0035591	Length:	703	Species:	Drosophila melanogaster
Sequence 2:	XP_021326780.1	Gene:	ptcd1 / 570247	ZFINID:	ZDB-GENE-030131-6146	Length:	697	Species:	Danio rerio

Alignment Length:	611	Identity:	174/611 - (28%)
Similarity:	295/611 - (48%)	Gaps:	83/611 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   117 DAKVAATEDPGDVEE---EEFLSNSTRRSKKLKAVEYARQIKDHLKANRLNEAIAVLEQRMLKED 178
            |.|....|:..|.::   |:|.|.:.||:   ....|..|.|..:|.::|.||:.:.|..|||.:
Zfish   107 DLKYRNPEEEDDEDQKPVEKFKSRTGRRN---TPYWYFLQCKRLIKEDKLAEALLMFEAEMLKGE 168

  Fly   179 RAKPDKYIYNLLISGCAKAGYTRKAFFLYTKMRQRGLQVTGGTYTSLFNACANAPSVSDGLAKAQ 243
            |.:|:::.|.:||.||.:.||.:|||.||..|::|.::.:..|||:||||||.:|....||.:|.
Zfish   169 RLQPEEFNYTVLIGGCGRVGYLKKAFQLYNNMKKRSIEPSDATYTALFNACAESPWKQSGLEQAL 233

  Fly   244 ILRENMLEKGYEPNVKNYNAMIKAYGRCGDVDTAYMLADEMMERQLELNADTFNFLLQACASNSE 308
            .|::.:|:|....:....:|::|.....||:.:.:.|..||::....:..:||.:||.:|.::.:
Zfish   234 KLKQELLKKNIALSAITQHALLKTVALAGDLQSCFQLLREMLQNGQPITQETFQYLLISCVNDKQ 298

  Fly   309 HGFRHALLTWHNMLQRGISPDYYSFNAMLRCARDCGFGDLDSMREVIDKIAPSAARKKPVLQLEK 373
            ||||.||..||.||..||.||..::|.:||.|||||.||.:....::.|.....|..|    :..
Zfish   299 HGFRLALQVWHQMLNIGIKPDAQNYNILLRAARDCGIGDPNLASAILLKRPEDEANPK----ITS 359

  Fly   374 GQQDDLPSVEANTTTLPAQIEV---------------ATTASELE-------------------- 403
            |::.....|:|.|:.....|:.               .|..|||:
Zfish   360 GRKSRRAKVKAETSCQHLDIDAFENELFVDTQTQRLGLTKESELKEKDQSIKDASQDETQMLPVS 424

  Fly   404 -----------------LPNLLLPQPHLGSLVALEEVTRPHERFLLLGGLTGFLEHMKQHNITPD 451
                             |||||.|:....|:|||..|....:|..|:|.|.||||.|.:..:.|:
Zfish   425 PSGSLTCQSELSAHSSSLPNLLEPRTCHSSVVALGSVNSASDRLALIGNLEGFLEKMAKDGLKPN 489

  Fly   452 IETFTAMLEVIPPTNAAEKQLLTFVRKIGLKADIDFFNILIKKRSMRFDYESAKEVLLMIRTAGL 516
            |:|.|.:.:|:...:.:.:.|:...::..:|.|:.|||.:||:.:...|.:.||.|..::...||
Zfish   490 IKTITLLADVMEAGSQSVQSLIDVAKRSHVKLDVPFFNTVIKRVAKAGDLDGAKAVKALMVDRGL 554

  Fly   517 RPDIVTYGVLALGCRTQEEARELLEQMHVAGIKMNMPILGAMLRQGCANKSFSYVNEIIQLSLEE 581
            ..:..|:..:||.||.:|:|.:|...|...||..|..|..|::.||.....::|::|:::...:.
Zfish   555 VANAQTFCSIALACRREEDAMQLFTDMEACGIVPNAHIYSALISQGLKRLDYAYLHELLKHMHKM 619

  Fly   582 GLKPNEAFLRHLHNFHRGCARAIDARHPSTKTAAFKKGHSKFCDK---YRLYYEEQGLSGLKLED 643
            .:.|||..:|.|.         ..:::|.:....  |..:.:.|:   :|.:|:|.      ||.
Zfish   620 QVPPNEVIIRQLE---------FASQYPPSYDKL--KSQNVYLDRIDGFRGFYKEW------LEF 667

  Fly   644 AIAKVKERPYDQFKLP-PVNGMEPLK 668
            ...:....|:.:::.| |.:..:.:|
Zfish   668 MPGQETPHPWAKYQSPKPESNQDGVK 693

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4611	NP_647949.1	PPR_2	<157..196	CDD:289786	15/38 (39%)
		PPR_2	182..231	CDD:289786	23/48 (48%)
		PPR	185..215	CDD:279828	14/29 (48%)
		PPR repeat	186..213	CDD:276811	13/26 (50%)
		PPR repeat	219..252	CDD:276811	15/32 (47%)
		PPR_1	252..284	CDD:289614	6/31 (19%)
		PPR_2	256..304	CDD:289786	11/47 (23%)
		PPR repeat	258..287	CDD:276811	7/28 (25%)
		PPR repeat	293..324	CDD:276811	15/30 (50%)
		PPR repeat	330..357	CDD:276811	10/26 (38%)
		PPR repeat	485..514	CDD:276811	9/28 (32%)
		PPR repeat	552..576	CDD:276811	6/23 (26%)
ptcd1	XP_021326780.1	PPR_3	166..337	CDD:329020	67/170 (39%)
		PPR repeat	174..203	CDD:276811	13/28 (46%)
		PPR_2	177..220	CDD:315669	21/42 (50%)
		PPR repeat	283..312	CDD:276811	13/28 (46%)
		PPR_2	<482..>598	CDD:330270	33/115 (29%)
		PPR repeat	526..552	CDD:276811	8/25 (32%)
		PPR repeat	558..584	CDD:276811	9/25 (36%)
		PPR repeat	590..619	CDD:276811	6/28 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	146	1.000	Domainoid score	I4500
eggNOG	1	0.900	-	-		E33208_3BFSV
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H33161
Inparanoid	1	1.050	264	1.000	Inparanoid score	I3062
OMA	1	1.010	-	-		QHG54853
OrthoDB	1	1.010	-	-		D195242at33208
OrthoFinder	1	1.000	-	-		FOG0007295
OrthoInspector	1	1.000	-	-		otm26188
orthoMCL	1	0.900	-	-		OOG6_106729
Panther	1	1.100	-	-	O	PTHR24014
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5607
SonicParanoid	1	1.000	-	-		X5397
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	14	13.960