DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4611 and ptcd1

DIOPT Version :9

Sequence 1:	NP_647949.1	Gene:	CG4611 / 38601	FlyBaseID:	FBgn0035591	Length:	703	Species:	Drosophila melanogaster
Sequence 2:	XP_002931567.1	Gene:	ptcd1 / 100135205	XenbaseID:	XB-GENE-940576	Length:	685	Species:	Xenopus tropicalis

Alignment Length:	633	Identity:	190/633 - (30%)
Similarity:	300/633 - (47%)	Gaps:	92/633 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    52 RITDQQAGLETKREANRNQNP----FREEVFEELITAAPKEHQK--FKPEKKPKEKSTKKVQDFG 110
            :|:.:|......|| |.|.||    ..:|.|.   |.|.|...:  ||       |::.::|..|
Frog    56 QISSRQRTFVLSRE-NNNTNPDVHSMEDETFG---TLAEKYSSRTFFK-------KTSPELQKLG 109

  Fly   111 DPDTFGDAKVAATEDPGDVEEEEFLSNSTRRSKKLKAVEYARQIKDHLKANRLNEAIAVLEQRML 175
            .            |:..|.||..:   ..|..::.....|..:.|..:|.::|.||:.:.|.:||
Frog   110 H------------EEDNDGEEPNY---PIRWRQRNTPYWYFLKCKAKIKEDKLAEALELFEVKML 159

  Fly   176 KEDRAKPDKYIYNLLISGCAKAGYTRKAFFLYTKMRQRGLQVTGGTYTSLFNACANAPSVSDGLA 240
            :|:|.:||:..|.:||.||.:|||.:|||.||..|::|||..|..|||:||||||.:|....||.
Frog   160 QEERLQPDESNYTILIGGCGRAGYVKKAFRLYADMKKRGLVPTDATYTALFNACAESPWKESGLQ 224

  Fly   241 KAQILRENMLEKGYEPNVKNYNAMIKAYGRCGDVDTAYMLADEMMERQLELNADTFNFLLQACAS 305
            :|..||:.:..|....|:..|.:::|....|.|:..:..:..|:::....:..||||.||.:|..
Frog   225 QALKLRQELKAKNIRLNLVTYQSLLKVCALCSDLQNSMEIFKEIVQEGHIVTKDTFNILLMSCIK 289

  Fly   306 NSEHGFRHALLTWHNMLQRGISPDYYSFNAMLRCARDCGFGD-LDSMREVIDKIAPSAARKK--- 366
            |.:.|||:.|..|..||:.||.||..::|.:||..||||.|| .::...::....|:..|.|
Frog   290 NKDIGFRYTLQVWRQMLRLGIKPDNSTYNLLLRATRDCGIGDSAEASALLLSSKEPTPLRLKAKT 354

  Fly   367 ----------------PVLQLEK------------GQQDDLPSVE----ANTTTLPAQIE----- 394
                            .|..|||            ...|.:.:.|    .||.:.|.:.:
Frog   355 GKHIHGMKKKANTSELDVEMLEKQLFLSKSTQLRISDSDGVDTQENAKGVNTISHPPRSQEICDS 419

  Fly   395 -VATTASELELPNLLLPQPHLGSLVALEEVTRPHERFLLLGGLTGFLEHMKQHNITPDIETFTAM 458
             :.|:::.|.|||||....:...:|:|..|..|.:|..|:||:.|.::.|....:.|.|:|||.:
Frog   420 LILTSSASLHLPNLLDEPANTNVIVSLGSVFTPSDRLALIGGMEGIIQKMHNDKVFPTIKTFTLL 484

  Fly   459 LEVIPPTNAAEKQLLTFVRKIGLKADIDFFNILIKKRSMRFDYESAKEVLLMIRTAGLRPDIVTY 523
            .|:|.|....|..|...:....:|||:.|||.||:|||...:..||||:|.::...|:.|:|.|:
Frog   485 AEIIQPDCKRESALFNIMDSANVKADVTFFNTLIRKRSKLINLHSAKELLPILAQKGISPNIQTF 549

  Fly   524 GVLALGCRTQEEARELLEQMHVAGIKMNMPILGAMLRQGCANKSFSYVNEIIQLSLEEGLKPNEA 588
            ..||:.|...||..:|||.|..:|:..|..|...::........::|:.:|::...:..:.|||.
Frog   550 CGLAISCHNAEEGLKLLEDMTNSGVIPNTYIYSTLISAAVKRLDYAYLLDILRDMKKRNVAPNEV 614

  Fly   589 FLRHLHNFHRGCARAIDARHPSTKTAAFKKGHSK--FCDK---YRLYY 631
            .:..|.         ..:::|..    :.|..||  |.:|   :|.||
Frog   615 IIHQLE---------FASQYPPN----YDKYKSKDVFLEKIDGFRGYY 649

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4611	NP_647949.1	PPR_2	<157..196	CDD:289786	16/38 (42%)
		PPR_2	182..231	CDD:289786	28/48 (58%)
		PPR	185..215	CDD:279828	15/29 (52%)
		PPR repeat	186..213	CDD:276811	14/26 (54%)
		PPR repeat	219..252	CDD:276811	15/32 (47%)
		PPR_1	252..284	CDD:289614	6/31 (19%)
		PPR_2	256..304	CDD:289786	12/47 (26%)
		PPR repeat	258..287	CDD:276811	5/28 (18%)
		PPR repeat	293..324	CDD:276811	15/30 (50%)
		PPR repeat	330..357	CDD:276811	9/27 (33%)
		PPR repeat	485..514	CDD:276811	13/28 (46%)
		PPR repeat	552..576	CDD:276811	3/23 (13%)
ptcd1	XP_002931567.1	PLN03218	<139..>355	CDD:215636	83/215 (39%)
		PPR repeat	171..197	CDD:276811	14/25 (56%)
		PPR repeat	203..236	CDD:276811	15/32 (47%)
		PPR repeat	242..271	CDD:276811	5/28 (18%)
		PPR repeat	277..308	CDD:276811	15/30 (50%)
		PPR repeat	314..344	CDD:276811	9/29 (31%)
		PPR repeat	514..540	CDD:276811	12/25 (48%)
		PPR repeat	546..572	CDD:276811	11/25 (44%)
		PPR_3	564..>612	CDD:316342	9/47 (19%)
		PPR repeat	578..607	CDD:276811	3/28 (11%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H33161
Inparanoid	1	1.050	270	1.000	Inparanoid score	I2942
OMA	1	1.010	-	-		QHG54853
OrthoDB	1	1.010	-	-		D195242at33208
OrthoFinder	1	1.000	-	-		FOG0007295
OrthoInspector	1	1.000	-	-		oto102436
Panther	1	1.100	-	-	LDO	PTHR24014
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5607
SonicParanoid	1	1.000	-	-		X5397
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	11	11.110