DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Prpk and Trp53rkb

DIOPT Version :9

Sequence 1:	NP_647948.1	Gene:	Prpk / 38600	FlyBaseID:	FBgn0035590	Length:	224	Species:	Drosophila melanogaster
Sequence 2:	XP_006500434.1	Gene:	Trp53rkb / 76367	MGIID:	1914050	Length:	268	Species:	Mus musculus

Alignment Length:	222	Identity:	102/222 - (45%)
Similarity:	141/222 - (63%)	Gaps:	4/222 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 LEILKQGAEGRLYLGDFKGEACLIKERFVKKYRHPELNTQITRQRMKAEAKASGRCLAAGILAPK 67
            ||:::||||.|::.|.|:|.|.::|.||.|.||||||..::.|:|...||:|..||..|||.||.
Mouse    51 LELVQQGAEARVFRGRFQGRAAVVKHRFPKSYRHPELEARLGRRRTVQEARALLRCRRAGIAAPV 115

  Fly    68 ILHSDLNTHKLYMEYFDAAKTAKQFIQETVSTQTEDEAKKCLLEFCTRIGEIIGKMHSNHIIHGD 132
            :...|..::.||||..:.:.|.:.:||.|:.|:.:.:   |||:...|:|:::..||...:||||
Mouse   116 VFFVDYASNCLYMEEIEDSVTVRDYIQSTMETEKDPQ---CLLDLARRMGQVLAGMHDQDLIHGD 177

  Fly   133 LTTSNILINPKGGDYDVILIDFGLSHYNQATEDKGVDLYVLERALLSTHSEQPYIFEHVLAAYRT 197
            |||||:|:........::|||||||..:...|||||||||||:|.||||......||..|.:| .
Mouse   178 LTTSNMLLRRPLAQLHIVLIDFGLSFVSGLPEDKGVDLYVLEKAFLSTHPHTETAFEAFLKSY-G 241

  Fly   198 ACGKDEQAVLTKFEEVRARGRKRTMIG 224
            |..|....||.|.:|||.|||||:|:|
Mouse   242 ASSKKSSPVLKKLDEVRLRGRKRSMVG 268

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Prpk	NP_647948.1	PKc_like	3..224	CDD:304357	101/220 (46%)
Trp53rkb	XP_006500434.1	Bud32	51..268	CDD:226168	101/220 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167840818
Domainoid	1	1.000	121	1.000	Domainoid score	I5687
eggNOG	1	0.900	-	-		E1_COG3642
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H6042
Inparanoid	1	1.050	196	1.000	Inparanoid score	I3801
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG62179
OrthoDB	1	1.010	-	-		D1425238at2759
OrthoFinder	1	1.000	-	-		FOG0003198
OrthoInspector	1	1.000	-	-		otm43525
orthoMCL	1	0.900	-	-		OOG6_101388
Panther	1	1.100	-	-	LDO	PTHR12209
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R156
SonicParanoid	1	1.000	-	-		X2602
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	16	15.800