DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Prpk and Trp53rka

DIOPT Version :9

Sequence 1:	NP_647948.1	Gene:	Prpk / 38600	FlyBaseID:	FBgn0035590	Length:	224	Species:	Drosophila melanogaster
Sequence 2:	NP_001007582.1	Gene:	Trp53rka / 381406	MGIID:	1918294	Length:	244	Species:	Mus musculus

Alignment Length:	222	Identity:	101/222 - (45%)
Similarity:	142/222 - (63%)	Gaps:	4/222 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 LEILKQGAEGRLYLGDFKGEACLIKERFVKKYRHPELNTQITRQRMKAEAKASGRCLAAGILAPK 67
            ||:::||||.|::.|.|:|.|.::|.||.|.||||||..::.|:|...||:|..||..|||.||.
Mouse    27 LELVQQGAEARVFRGRFQGRAAVVKHRFPKSYRHPELEARLGRRRTVQEARALLRCRRAGIAAPV 91

  Fly    68 ILHSDLNTHKLYMEYFDAAKTAKQFIQETVSTQTEDEAKKCLLEFCTRIGEIIGKMHSNHIIHGD 132
            :...|..::.||||..:.:.|.:.:||.|:.|:.:.:   |||:...|:|:::..||...:||||
Mouse    92 VFFVDYASNCLYMEEIEDSVTVRDYIQSTMETEKDPQ---CLLDLARRMGQVLAGMHDQDLIHGD 153

  Fly   133 LTTSNILINPKGGDYDVILIDFGLSHYNQATEDKGVDLYVLERALLSTHSEQPYIFEHVLAAYRT 197
            |||||:|:........::|||||||..:...|||||||||||:|.||||.....:||..|.:|..
Mouse   154 LTTSNMLLRRPLAQLHIVLIDFGLSFVSGLPEDKGVDLYVLEKAFLSTHPHTETVFEAFLKSYGA 218

  Fly   198 ACGKDEQAVLTKFEEVRARGRKRTMIG 224
            :..| ...||.|.:|||.|||||:|:|
Mouse   219 STQK-SSPVLKKLDEVRLRGRKRSMVG 244

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Prpk	NP_647948.1	PKc_like	3..224	CDD:304357	100/220 (45%)
Trp53rka	NP_001007582.1	Bud32	27..244	CDD:226168	100/220 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167840817
Domainoid	1	1.000	121	1.000	Domainoid score	I5687
eggNOG	1	0.900	-	-		E1_COG3642
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H6042
Inparanoid	1	1.050	196	1.000	Inparanoid score	I3801
Isobase	1	0.950	-	0	Normalized mean entropy	S1720
OMA	1	1.010	-	-		QHG62179
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003198
OrthoInspector	1	1.000	-	-		otm43525
orthoMCL	1	0.900	-	-		OOG6_101388
Panther	1	1.100	-	-	O	PTHR12209
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2602
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	16	15.710