DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment KRT13 and LamC

DIOPT Version :9

Sequence 1:	NP_705694.3	Gene:	KRT13 / 3860	HGNCID:	6415	Length:	458	Species:	Homo sapiens
Sequence 2:	NP_001260974.1	Gene:	LamC / 36615	FlyBaseID:	FBgn0010397	Length:	640	Species:	Drosophila melanogaster

Alignment Length:	412	Identity:	123/412 - (29%)
Similarity:	193/412 - (46%)	Gaps:	75/412 - (18%)

- Green bases have known domain annotations that are detailed below.

Human   104 EKITMQNLNDRLASYLEKVRALEEANADLEVKIRDWHLKQSPASPERD--YSPYYKTIEELRDKI 166
            ||..:|:||||||.|::::|.||..|:.|   .::.:|.|...:.|..  .:.|.|.:...| |:
  Fly    46 EKEELQHLNDRLACYIDRMRNLENENSRL---TQELNLAQDTVNRETSNLKAVYEKELAAAR-KL 106

Human   167 LTATIENNRVILEIDNARLAADDFRLK------------YENELALRQSVEADING--------- 210
            |..|.: .:..||||..||..::..||            .||...|.::...::||
  Fly   107 LDETAK-EKAKLEIDIKRLWEENDDLKPRLDKKTKEATVAENNARLYENRYNEVNGKYNQSLADR 170

Human   211 ----------------LRRVLDEL-------TLSKTDLEMQIESLNEELAYMKKNHEEEMKEFS- 251
                            |||.||:|       ||::.|||.|.:||.||||:..:.|.:|:.|..
  Fly   171 KKFEDQAKELALENERLRRQLDDLRKQLEAETLARVDLENQNQSLREELAFKDQVHTQELTETRS 235

Human   252 ------NQVVGQVNVEMDATPGIDLTRVLAEMREQYEAMAERNRRDAEEWFHTKSAELNKEVSTN 310
                  :::.|:::.:.:|    .|.:.|.|:|:|||.....||.:.|..:..:...| |..:..
  Fly   236 RRQIEISEIDGRLSRQYEA----KLQQSLQELRDQYEGQMRINREEIELLYDNEIQNL-KAAANR 295

Human   311 TAMIQTSKTEITELRRT-LQGLEIELQSQLSMKAGLENTVAETECRYALQLQQIQGLISSIEAQL 374
            .|......||...|.|| :.||..:||:.....|||...:.|.|.....:.|:....|:|:||:|
  Fly   296 AAQGSALATEEVRLMRTKIDGLNAKLQNLEDTNAGLNARIRELENLLDTERQRHNQYIASLEAEL 360

Human   375 SELRSEMECQNQEYKMLLDIKTRLEQEIATYRSLLEGQDAKM----IGFPSSAGSVSPRSTSVTT 435
            ..:|.||..|.|||:.|:|||..|:.|||.|..||.|::.::    .|.|::...:|...:.:|.
  Fly   361 QRMRDEMAHQLQEYQGLMDIKVSLDLEIAAYDKLLCGEERRLNIESPGRPTTDSGISSNGSHLTA 425

Human   436 TSSASVTTTSNASGRRTSDVRR 457
            ::       |:.|||.|...||
  Fly   426 SA-------SSRSGRVTPSGRR 440

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
KRT13	NP_705694.3	Head	1..103
		Filament	103..415	CDD:306535	112/364 (31%)
		Coil 1A	104..139		15/34 (44%)
		Linker 1	140..158		4/19 (21%)
		Coil 1B	159..250		37/134 (28%)
		Linker 12	251..273		3/28 (11%)
		Coil 2	274..412		50/138 (36%)
		Tail	413..458		11/49 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	420..458		10/38 (26%)
LamC	NP_001260974.1	Filament	45..401	CDD:278467	112/364 (31%)
		ATP-synt_B	<67..>142	CDD:304375	21/79 (27%)
		MreC	<178..>224	CDD:302802	18/45 (40%)
		LTD	473..574	CDD:279300
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910