Protein Alignment CHMP2B and Chmp2a

DIOPT Version :10

• Sequence 1: NP_647947.1
• Gene: CHMP2B / 38599
• FlyBaseID: FBgn0035589
• Length: 212
• Species: Drosophila melanogaster
• Sequence 2: NP_081161.1
• Gene: Chmp2a / 68953
• MGIID: 1916203
• Length: 222
• Species: Mus musculus
• Alignment Length: 217
• Identity: 74/217 - (34%)
• Similarity: 134/217 - (61%)
• Gaps: 11/217 - (5%)

  Fly     5 IFGKKPTVKEQQRENDRSLRKATRDIERERRKMEEEERKLELEIRRNAAAGNNDACRILAKQLVE 69
            :||::.|.:|..|:|.|:|.:|.|:::|||:|:|.:|:|:..:|::.|..|..||.||:||.||.
Mouse     4 LFGRRKTPEELLRQNQRALNRAMRELDRERQKLETQEKKIIADIKKMAKQGQMDAVRIMAKDLVR 68

  Fly    70 IRKQKSRTYAAAGKIQSIGYQNKNMGANIALSEAMGTTAKTMGEMNKVMRPEAIGETVRQFQAAN 134
            .|:...:.......||::..:.:.:.:|.::::||....|.||.||:.::...|.:.:.:|:...
Mouse    69 TRRYVRKFVLMRANIQAVSLKIQTLKSNNSMAQAMKGVTKAMGTMNRQLKLPQIQKIMMEFERQA 133

  Fly   135 MKMEMTDEMINDTLDDMLNESGDEEESNAVVNKVLDEIGIEISGKMSSIPATGSS-DFETSGKRT 198
            ..|:|.:||:||.:||.:.:..|||||:|||::||||:|:.::.::|::|:||.| .....||:.
Mouse   134 EIMDMKEEMMNDAIDDAMGDEEDEEESDAVVSQVLDELGLSLTDELSNLPSTGGSLSVAAGGKKA 198

  Fly   199 E----------KDIADQLAKLR 210
            |          .|:.::|..||
Mouse   199 EATASALADADADLEERLKNLR 220

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CHMP2B	NP_647947.1	Snf7	18..186	CDD:460896	59/167 (35%)
Chmp2a	NP_081161.1	Snf7	17..185	CDD:460896	59/167 (35%)
		Interaction with VPS4B. /evidence=ECO:0000250	56..222		54/165 (33%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	179..198		7/18 (39%)
		MIT-interacting motif	210..220		2/9 (22%)
		Interaction with VTA1. /evidence=ECO:0000250	217..222		2/4 (50%)