Protein Alignment CHMP2B and CHMP1B

DIOPT Version :9

• Sequence 1: NP_647947.1
• Gene: CHMP2B / 38599
• FlyBaseID: FBgn0035589
• Length: 212
• Species: Drosophila melanogaster
• Sequence 2: NP_065145.2
• Gene: CHMP1B / 57132
• HGNCID: 24287
• Length: 199
• Species: Homo sapiens
• Alignment Length: 197
• Identity: 41/197 - (20%)
• Similarity: 94/197 - (47%)
• Gaps: 18/197 - (9%)

  Fly    22 SLRKATRDIERERRKMEEEERKLELEIRRNAAAGNNDACRILAK-------QLVEIRKQKSRTYA 79
            :|:.|.:::.|..:|.::||:..:.:|::....||.:..||.|:       |.|...:..:|..|
Human    10 NLKFAAKELSRSAKKCDKEEKAEKAKIKKAIQKGNMEVARIHAENAIRQKNQAVNFLRMSARVDA 74

  Fly    80 AAGKIQSIGYQNKNMGANIALSEAMGTTAKTMGEMNKVMRPEAIGETVRQFQAANMKMEMTDEMI 144
            .|.::|:.....|       ::::|....|:|....|.|..|.|...:.:|:.....:::..:.:
Human    75 VAARVQTAVTMGK-------VTKSMAGVVKSMDATLKTMNLEKISALMDKFEHQFETLDVQTQQM 132

  Fly   145 NDTLDDMLNESGDEEESNAVVNKVLDEIGIEISGKMSSIPATGSSDFETSGKRTEKD-IADQLAK 208
            .||:......:..:.:.:.::.::.||.|::::   ..:|...:....||....|:| ::.:||:
Human   133 EDTMSSTTTLTTPQNQVDMLLQEMADEAGLDLN---MELPQGQTGSVGTSVASAEQDELSQRLAR 194

  Fly   209 LR 210
            ||
Human   195 LR 196

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CHMP2B	NP_647947.1	Snf7	18..186	CDD:281366	33/170 (19%)
CHMP1B	NP_065145.2	Snf7	49..189	CDD:419749	28/149 (19%)
		Interaction with IST1	132..156		2/23 (9%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	167..199		9/30 (30%)
		Interaction with SPAST. /evidence=ECO:0000269|PubMed:15537668	174..199		8/23 (35%)
		Interaction with VTA1	180..199		6/17 (35%)
		Interaction with VPS4A, MITD1 and STAMBP. /evidence=ECO:0000269|PubMed:19129480	180..196		4/15 (27%)
		Interaction with VPS4B	183..199		6/14 (43%)
		MIT-interacting motif	186..196		3/9 (33%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5491
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810