DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CHMP2B and chmp2bb

DIOPT Version :9

Sequence 1:	NP_647947.1	Gene:	CHMP2B / 38599	FlyBaseID:	FBgn0035589	Length:	212	Species:	Drosophila melanogaster
Sequence 2:	NP_998069.1	Gene:	chmp2bb / 405840	ZFINID:	ZDB-GENE-040426-2539	Length:	214	Species:	Danio rerio

Alignment Length:	206	Identity:	97/206 - (47%)
Similarity:	142/206 - (68%)	Gaps:	4/206 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 KKPTVKEQQRENDRSLRKATRDIERERRKMEEEERKLELEIRRNAAAGNNDACRILAKQLVEIRK 72
            ||.||.:..:|.::.||...|.|.|:|..:|::|::||:||::.|..||.|||::||||||::||
Zfish     6 KKKTVDDVIKEQNKELRGTQRQIARDRTALEKQEKQLEMEIKKMAKTGNRDACKVLAKQLVQVRK 70

  Fly    73 QKSRTYAAAGKIQSIGYQNKNMGANIALSEAMGTTAKTMGEMNKVMRPEAIGETVRQFQAANMKM 137
            ||:||||.:.|:.|:..|.|.|.:.:.::.||.||.|||..:||.|.|:...:|::.||....||
Zfish    71 QKTRTYAVSSKVTSMSTQTKLMNSQMKMAGAMATTTKTMQAVNKKMDPKKTMQTLQNFQKETAKM 135

  Fly   138 EMTDEMINDTLDDMLNESGDEEESNAVVNKVLDEIGIEISGKMSSIPA----TGSSDFETSGKRT 198
            :||:||:|||||::..:|||||||..:||:|||||||||||||:..|:    |.|:....:...:
Zfish   136 DMTEEMMNDTLDEIFEDSGDEEESQDIVNQVLDEIGIEISGKMAHAPSAARKTPSAATAKADGIS 200

  Fly   199 EKDIADQLAKL 209
            ::||..||..|
Zfish   201 DEDIERQLKAL 211

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CHMP2B	NP_647947.1	Snf7	18..186	CDD:281366	86/171 (50%)
chmp2bb	NP_998069.1	Snf7	16..185	CDD:281366	86/168 (51%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	178..199		4/20 (20%)
		MIT-interacting motif	202..212		5/10 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170573455
Domainoid	1	1.000	180	1.000	Domainoid score	I3459
eggNOG	1	0.900	-	-		E1_COG5491
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H8534
Inparanoid	1	1.050	188	1.000	Inparanoid score	I3893
OMA	1	1.010	-	-		QHG53529
OrthoDB	1	1.010	-	-		D1480977at2759
OrthoFinder	1	1.000	-	-		FOG0005657
OrthoInspector	1	1.000	-	-		otm25784
orthoMCL	1	0.900	-	-		OOG6_105602
Panther	1	1.100	-	-	O	PTHR10476
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3454
SonicParanoid	1	1.000	-	-		X4058
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	15	14.840