DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CHMP2B and CHMP2B

DIOPT Version :9

Sequence 1:	NP_647947.1	Gene:	CHMP2B / 38599	FlyBaseID:	FBgn0035589	Length:	212	Species:	Drosophila melanogaster
Sequence 2:	XP_011531878.1	Gene:	CHMP2B / 25978	HGNCID:	24537	Length:	229	Species:	Homo sapiens

Alignment Length:	201	Identity:	102/201 - (50%)
Similarity:	140/201 - (69%)	Gaps:	7/201 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 VKEQQRENDRSLRKATRDIERERRKMEEEERKLELEIRRNAAAGNNDACRILAKQLVEIRKQKSR 76
            :|||.||    ||...|.|.|:|..:|::|::|||||::.|..||.:||::||||||.:||||:|
Human    30 IKEQNRE----LRGTQRAIIRDRAALEKQEKQLELEIKKMAKIGNKEACKVLAKQLVHLRKQKTR 90

  Fly    77 TYAAAGKIQSIGYQNKNMGANIALSEAMGTTAKTMGEMNKVMRPEAIGETVRQFQAANMKMEMTD 141
            |:|.:.|:.|:..|.|.|.:.:.::.||.||||||..:||.|.|:...:|::.||..|||||||:
Human    91 TFAVSSKVTSMSTQTKVMNSQMKMAGAMSTTAKTMQAVNKKMDPQKTLQTMQNFQKENMKMEMTE 155

  Fly   142 EMINDTLDDMLNESGDEEESNAVVNKVLDEIGIEISGKMSSIP-ATGSSDFETSGKRT--EKDIA 203
            |||||||||:.:.|.|||||..:||:|||||||||||||:..| |..|....::.|.|  :::|.
Human   156 EMINDTLDDIFDGSDDEEESQDIVNQVLDEIGIEISGKMAKAPSAARSLPSASTSKATISDEEIE 220

  Fly   204 DQLAKL 209
            .||..|
Human   221 RQLKAL 226

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CHMP2B	NP_647947.1	Snf7	18..186	CDD:281366	90/168 (54%)
CHMP2B	XP_011531878.1	Snf7	32..201	CDD:281366	92/168 (55%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165140741
Domainoid	1	1.000	183	1.000	Domainoid score	I3447
eggNOG	1	0.900	-	-		E1_COG5491
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H8534
Inparanoid	1	1.050	190	1.000	Inparanoid score	I3892
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53529
OrthoDB	1	1.010	-	-		D1480977at2759
OrthoFinder	1	1.000	-	-		FOG0005657
OrthoInspector	1	1.000	-	-		oto90766
orthoMCL	1	0.900	-	-		OOG6_105602
Panther	1	1.100	-	-	LDO	PTHR10476
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3454
SonicParanoid	1	1.000	-	-		X4058
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.800