Protein Alignment Dhrs4 and CBR4

DIOPT Version :10

• Sequence 1: NP_647946.1
• Gene: Dhrs4 / 38598
• FlyBaseID: FBgn0035588
• Length: 317
• Species: Drosophila melanogaster
• Sequence 2: XP_006714454.1
• Gene: CBR4 / 84869
• HGNCID: 25891
• Length: 247
• Species: Homo sapiens
• Alignment Length: 254
• Identity: 84/254 - (33%)
• Similarity: 123/254 - (48%)
• Gaps: 25/254 - (9%)

  Fly    72 KVAVVTASTDGIGFAIAKRLAEDGAAVVISSRKQKNVDSALAELRKLNLNVHGLKCHVSEPEDRK 136
            ||..|...:.|||.|:|:.:|..|..:.:.:|   |::.|.|....|..:.....|.|::..|.:
Human     3 KVCAVFGGSRGIGRAVAQLMARKGYRLAVIAR---NLEGAKAAAGDLGGDHLAFSCDVAKEHDVQ 64

  Fly   137 QLFEETISKFGKLNILVSNAATNPAVGGVLECDEKVWDKI--FDVNVKSSYLLAKEALPLLRQQK 199
            ..|||.....|::|.||:.|..|.  .|:| ...|..|.:  ...|:..|.|..|.|:..:.||:
Human    65 NTFEELEKHLGRVNFLVNAAGINR--DGLL-VRTKTEDMVSQLHTNLLGSMLTCKAAMRTMIQQQ 126

  Fly   200 NSSIVFVS----------SIAGYDAFELLGAYSVSKTALIGLTKAAAKDLAPEGIRVNCLAPGVI 254
            ..|||.|.          ||.|.........||.||..|:|.::|.||::|.:.||||.:|||.:
Human   127 GGSIVNVGHRREMLLHKRSIVGLKGNSGQSVYSASKGGLVGFSRALAKEVARKKIRVNVVAPGFV 191

  Fly   255 RTKFSKALYENESANEAALSKIPMGRLGTSEEMAGVVSFLVSEDAGYITGESIVAGGGM 313
            .|..:|.|.|     |.....||:||.|.:.|:|..|.||:  ::.||||..:|..||:
Human   192 HTDMTKDLKE-----EHLKKNIPLGRFGETIEVAHAVVFLL--ESPYITGHVLVVDGGL 243

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dhrs4	NP_647946.1	Rossmann-fold NAD(P)(+)-binding proteins	67..317	CDD:473865	84/254 (33%)
CBR4	XP_006714454.1	Rossmann-fold NAD(P)(+)-binding proteins	3..243	CDD:473865	83/252 (33%)