Protein Alignment Dhrs4 and Dhrs2

DIOPT Version :10

• Sequence 1: NP_647946.1
• Gene: Dhrs4 / 38598
• FlyBaseID: FBgn0035588
• Length: 317
• Species: Drosophila melanogaster
• Sequence 2: NP_082066.2
• Gene: Dhrs2 / 71412
• MGIID: 1918662
• Length: 282
• Species: Mus musculus
• Alignment Length: 260
• Identity: 135/260 - (51%)
• Similarity: 170/260 - (65%)
• Gaps: 4/260 - (1%)

  Fly    54 LSSSSQSSTAGTMKRLAGKVAVVTASTDGIGFAIAKRLAEDGAAVVISSRKQKNVDSALAELRKL 118
            ||:...|.||...:.|||||||:|.||.|||||||:|||:|||.||||||||:|||.|:..|::.
Mouse    20 LSARRFSKTADENRSLAGKVAVITGSTRGIGFAIARRLAQDGAHVVISSRKQENVDEAVTILKEE 84

  Fly   119 NLNVHGLKCHVSEPEDRKQLFEETISKFGKLNILVSNAATNPAVGGVLECDEKVWDKIFDVNVKS 183
            .|:|.|..|||.:.|||:.|....:...|.::.||..|..||.||..|...|::||||.||||||
Mouse    85 GLSVTGTMCHVGKAEDRQHLVTTALKHSGGIDFLVCVAGVNPLVGSTLGASEQIWDKILDVNVKS 149

  Fly   184 SYLLAKEALPLLRQQKNSSIVFVSSIAGYDAFELLGAYSVSKTALIGLTKAAAKDLAPEGIRVNC 248
            ..||..:.||.:..::..|:|.|||...|.....||.|:.|||||:||.|:.|.:|||:||||||
Mouse   150 PALLLSKVLPYMENRRGGSVVLVSSGVAYVPVPKLGVYNTSKTALLGLCKSLAVELAPKGIRVNC 214

  Fly   249 LAPGVIRTKFSKALYENESANEAA-LSKI-PMGRLGTSEEMAGVVSFLVSEDAGYITGESIVAGG 311
            |.||:|:|.||  |.|....|... ::|| .:.|||..||.||:||||.|.||.|||||:|:..|
Mouse   215 LVPGIIKTDFS--LREKTMPNMLPDMNKIFGVKRLGEPEECAGLVSFLCSSDASYITGENIMVAG 277

  Fly   312  311
            Mouse   278  277

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dhrs4	NP_647946.1	Rossmann-fold NAD(P)(+)-binding proteins	67..317	CDD:473865	130/247 (53%)
Dhrs2	NP_082066.2	Rossmann-fold NAD(P)(+)-binding proteins	35..277	CDD:473865	129/243 (53%)