Protein Alignment Dhrs4 and Dhrs1

DIOPT Version :10

• Sequence 1: NP_647946.1
• Gene: Dhrs4 / 38598
• FlyBaseID: FBgn0035588
• Length: 317
• Species: Drosophila melanogaster
• Sequence 2: NP_081095.2
• Gene: Dhrs1 / 52585
• MGIID: 1196314
• Length: 313
• Species: Mus musculus
• Alignment Length: 251
• Identity: 72/251 - (28%)
• Similarity: 111/251 - (44%)
• Gaps: 18/251 - (7%)

  Fly    69 LAGKVAVVTASTDGIGFAIAKRLAEDGAAVVISSRKQKNVDSALAELRKLNLNVHGLKCHVSEPE 133
            :.|:|.|||.::.|||..||.:|.:.||.|.|:.|....:.:...|.:.|......:.|..|:..
Mouse     5 MKGQVCVVTGASRGIGRGIALQLCKAGATVYITGRHLDTLRATAQEAQSLGGRCVPVVCDSSQES 69

  Fly   134 DRKQLFEET-ISKFGKLNILVSNAATNPAVGGVLECDEK--------VWDKIFDVNVKSSYLLAK 189
            :.|.|||:. ..:.|:|::||:||..  .|..:|....|        :||.|.:|.::..||.:.
Mouse    70 EVKSLFEQVDREQKGRLDVLVNNAYA--GVQAILNTTNKSFWEVPASIWDDINNVGLRGHYLCSV 132

  Fly   190 EALPLLRQQKNSSIVFVSSIAGYD-AFELLGAYSVSKTALIGLTKAAAKDLAPEGIRVNCLAPGV 253
            ....|:.......||.|||..|.. .|.:  .|.|.|.|...|....|.:|...|:....|.||:
Mouse   133 YGARLMVPAGKGLIVIVSSPGGLQHMFNV--PYGVGKAACDRLAADCAHELRRHGVSYVSLWPGL 195

  Fly   254 IRTKFSKALYENESANEAALSK--IPMGRLGTSEEMAG--VVSFLVSEDAGYITGE 305
            ::|:..|.....|...|..|.|  .|......|.||:|  ||:.....:...::|:
Mouse   196 VQTEMVKEFMAKEDTPEDPLFKKMKPDFSSAESPEMSGKCVVALATDPNILNLSGK 251

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dhrs4	NP_647946.1	Rossmann-fold NAD(P)(+)-binding proteins	67..317	CDD:473865	72/251 (29%)
Dhrs1	NP_081095.2	DHRS1-like_SDR_c	5..271	CDD:187664	72/251 (29%)