Protein Alignment Dhrs4 and Hsd17b8

DIOPT Version :10

• Sequence 1: NP_647946.1
• Gene: Dhrs4 / 38598
• FlyBaseID: FBgn0035588
• Length: 317
• Species: Drosophila melanogaster
• Sequence 2: XP_006256026.1
• Gene: Hsd17b8 / 361802
• RGDID: 1303158
• Length: 273
• Species: Rattus norvegicus
• Alignment Length: 249
• Identity: 81/249 - (32%)
• Similarity: 126/249 - (50%)
• Gaps: 20/249 - (8%)

  Fly    76 VTASTDGIGFAIAKRLAEDGAAVVISSRKQKNVDSALA------------ELRKLNLNVHGLKCH 128
            ::.:..|||.||:.|||.:||||...     ::|.|.|            |.|:........:..
  Rat    16 ISGAGSGIGRAISVRLAAEGAAVAAC-----DLDGAAAQDTVRLLGNPGSEDREPRGKHAAFQAD 75

  Fly   129 VSEPEDRKQLFEETISKFGKLNILVSNAATNPAVGGVLECDEKVWDKIFDVNVKSSYLLAKEAL- 192
            |||....|:|.|:..:.|.:...:|.:.|.......:|...|:.||::..||:|.::|:.:.|.
  Rat    76 VSEGPAAKRLLEQVQACFFRPPSVVVSCAGITRDEFLLHMSEEDWDRVIAVNLKGTFLVTQAAAQ 140

  Fly   193 PLLRQQKNSSIVFVSSIAGYDAFELLGAYSVSKTALIGLTKAAAKDLAPEGIRVNCLAPGVIRTK 257
            .|:......||:.:|||.|.........|:.||..:||||:.||::|...|||.|.:.||.|.|.
  Rat   141 ALVSSGGRGSIINISSIVGKVGNIGQTNYASSKAGVIGLTQTAARELGRHGIRCNSVLPGFIATP 205

  Fly   258 FSKALYENESANEAALSKIPMGRLGTSEEMAGVVSFLVSEDAGYITGESIVAGG 311
            .::.:  .|...:...:.||:|.:|..|::|.||:||.|||:|||||.|:...|
  Rat   206 MTQKM--PEKVKDKVTAMIPLGHMGDPEDVADVVAFLASEDSGYITGASVEVSG 257

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dhrs4	NP_647946.1	Rossmann-fold NAD(P)(+)-binding proteins	67..317	CDD:473865	81/249 (33%)
Hsd17b8	XP_006256026.1	BKR_SDR_c	16..257	CDD:187594	80/247 (32%)