DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10672 and Dhrs4

DIOPT Version :9

Sequence 1:	NP_647946.1	Gene:	CG10672 / 38598	FlyBaseID:	FBgn0035588	Length:	317	Species:	Drosophila melanogaster
Sequence 2:	NP_001033027.2	Gene:	Dhrs4 / 28200	MGIID:	90169	Length:	279	Species:	Mus musculus

Alignment Length:	263	Identity:	132/263 - (50%)
Similarity:	188/263 - (71%)	Gaps:	2/263 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly    57 SSQSSTAGTMKR--LAGKVAVVTASTDGIGFAIAKRLAEDGAAVVISSRKQKNVDSALAELRKLN 119
            |.:.:::|..:|  |:.|||:|||||||||||||:|||||||.||:|||||:|||.|:|.|:...
Mouse    17 SVRMASSGLTRRNPLSNKVALVTASTDGIGFAIARRLAEDGAHVVVSSRKQQNVDRAVATLQGEG 81

  Fly   120 LNVHGLKCHVSEPEDRKQLFEETISKFGKLNILVSNAATNPAVGGVLECDEKVWDKIFDVNVKSS 184
            |:|.|:.|||.:.|||::|....:.:...::|||||||.||..|.:::..|:||||:..:||.::
Mouse    82 LSVTGIVCHVGKAEDREKLITTALKRHQGIDILVSNAAVNPFFGNLMDVTEEVWDKVLSINVTAT 146

  Fly   185 YLLAKEALPLLRQQKNSSIVFVSSIAGYDAFELLGAYSVSKTALIGLTKAAAKDLAPEGIRVNCL 249
            .::.|..:|.:.::...|:|.|.|:||:..|..||.|:||||||:||||..|.:|||:.||||||
Mouse   147 AMMIKAVVPEMEKRGGGSVVIVGSVAGFTRFPSLGPYNVSKTALLGLTKNFAAELAPKNIRVNCL 211

  Fly   250 APGVIRTKFSKALYENESANEAALSKIPMGRLGTSEEMAGVVSFLVSEDAGYITGESIVAGGGMT 314
            |||:|:|:||..|:|.::..:.....:.:.|||..|:.||:||||.||||.||.||::|.|||..
Mouse   212 APGLIKTRFSSVLWEEKAREDFIKEAMQIRRLGKPEDCAGIVSFLCSEDASYINGETVVVGGGTP 276

  Fly   315 ARL 317
            :||
Mouse   277 SRL 279

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10672	NP_647946.1	NADB_Rossmann	67..317	CDD:304358	128/251 (51%)
CG10672	NP_647946.1	fabG	67..316	CDD:235975	128/250 (51%)
Dhrs4	NP_001033027.2	CR_SDR_c	24..279	CDD:187641	129/254 (51%)
		fabG	31..274	CDD:235975	125/242 (52%)
		Microbody targeting signal	277..279		0/1 (0%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	240	1.000	Domainoid score	I2250
eggNOG	1	0.900	-	-		E2759_KOG0725
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H49646
Inparanoid	1	1.050	260	1.000	Inparanoid score	I3099
Isobase	1	0.950	-	0.772507	Normalized mean entropy	S1637
OMA	1	1.010	-	-		QHG57783
OrthoDB	1	1.010	-	-		D1194344at2759
OrthoFinder	1	1.000	-	-		FOG0000019
OrthoInspector	1	1.000	-	-		otm42967
orthoMCL	1	0.900	-	-		OOG6_102796
Panther	1	1.100	-	-	LDO	PTHR43943
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2055
SonicParanoid	1	1.000	-	-		X181
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	16	15.820