Protein Alignment Dhrs4 and DECR1

DIOPT Version :10

• Sequence 1: NP_647946.1
• Gene: Dhrs4 / 38598
• FlyBaseID: FBgn0035588
• Length: 317
• Species: Drosophila melanogaster
• Sequence 2: NP_001350.1
• Gene: DECR1 / 1666
• HGNCID: 2753
• Length: 335
• Species: Homo sapiens
• Alignment Length: 284
• Identity: 77/284 - (27%)
• Similarity: 132/284 - (46%)
• Gaps: 15/284 - (5%)

  Fly    37 NYSRKLVGPNLNQCHKRLSSSSQSSTAGTMKRLAGKVAVVTASTDGIGFAIAKRLAEDGAAVVIS 101
            :|..|::..|......:..|..|.:.. ......||||.:|....|:|..:...|:..||..||:
Human    26 SYGTKILYQNTEALQSKFFSPLQKAML-PPNSFQGKVAFITGGGTGLGKGMTTLLSSLGAQCVIA 89

  Fly   102 SRKQKNVDSALAELRKLNLN-VHGLKCHVSEPEDRKQLFEETISKFGKLNILVSNAATNPAVGGV 165
            |||...:.:...::.....| ||.::|.|.:|:..:....|.|...|..||:::|||.| .:...
Human    90 SRKMDVLKATAEQISSQTGNKVHAIQCDVRDPDMVQNTVSELIKVAGHPNIVINNAAGN-FISPT 153

  Fly   166 LECDEKVWDKIFDVNVKSSYLLAKE-ALPLLRQQKNSSIVFVSSIAGYDAFELLGAYSVSKTALI 229
            .......|..|.|:.:..:..:..| ...|::.||.::.:.:::|........:...:.:|..:.
Human   154 ERLSPNAWKTITDIVLNGTAFVTLEIGKQLIKAQKGAAFLSITTIYAETGSGFVVPSASAKAGVE 218

  Fly   230 GLTKAAAKDLAPEGIRVNCLAPGVIRTK--FSK----ALYENESANEAALSKIPMGRLGTSEEMA 288
            .::|:.|.:....|:|.|.:.||.|:||  ||:    ..:|.|     .:.:||.|||||.||:|
Human   219 AMSKSLAAEWGKYGMRFNVIQPGPIKTKGAFSRLDPTGTFEKE-----MIGRIPCGRLGTVEELA 278

  Fly   289 GVVSFLVSEDAGYITGESIVAGGG 312
            .:.:||.|:.|.:|.|..|...||
Human   279 NLAAFLCSDYASWINGAVIKFDGG 302

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dhrs4	NP_647946.1	Rossmann-fold NAD(P)(+)-binding proteins	67..317	CDD:473865	72/254 (28%)
DECR1	NP_001350.1	TER_DECR_SDR_a	57..303	CDD:187627	72/252 (29%)