DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10672 and DHRS4

DIOPT Version :9

Sequence 1:	NP_647946.1	Gene:	CG10672 / 38598	FlyBaseID:	FBgn0035588	Length:	317	Species:	Drosophila melanogaster
Sequence 2:	NP_066284.2	Gene:	DHRS4 / 10901	HGNCID:	16985	Length:	278	Species:	Homo sapiens

Alignment Length:	267	Identity:	136/267 - (50%)
Similarity:	186/267 - (69%)	Gaps:	2/267 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly    53 RLSSSSQSSTAGTMKR--LAGKVAVVTASTDGIGFAIAKRLAEDGAAVVISSRKQKNVDSALAEL 115
            |..:|.:.:::|..:|  ||.|||:|||||||||||||:|||:|||.||:|||||:|||.|:|.|
Human    12 RAWNSVRMASSGMTRRDPLANKVALVTASTDGIGFAIARRLAQDGAHVVVSSRKQQNVDQAVATL 76

  Fly   116 RKLNLNVHGLKCHVSEPEDRKQLFEETISKFGKLNILVSNAATNPAVGGVLECDEKVWDKIFDVN 180
            :...|:|.|..|||.:.|||::|....:...|.::|||||||.||..|.:::..|:||||..|:|
Human    77 QGEGLSVTGTVCHVGKAEDRERLVATAVKLHGGIDILVSNAAVNPFFGSIMDVTEEVWDKTLDIN 141

  Fly   181 VKSSYLLAKEALPLLRQQKNSSIVFVSSIAGYDAFELLGAYSVSKTALIGLTKAAAKDLAPEGIR 245
            ||:..|:.|..:|.:.::...|:|.|||||.:........|:||||||:||||..|.:|||..||
Human   142 VKAPALMTKAVVPEMEKRGGGSVVIVSSIAAFSPSPGFSPYNVSKTALLGLTKTLAIELAPRNIR 206

  Fly   246 VNCLAPGVIRTKFSKALYENESANEAALSKIPMGRLGTSEEMAGVVSFLVSEDAGYITGESIVAG 310
            |||||||:|:|.||:.|:.::...|:....:.:.|||..|:.||:||||.||||.|||||::|.|
Human   207 VNCLAPGLIKTSFSRMLWMDKEKEESMKETLRIRRLGEPEDCAGIVSFLCSEDASYITGETVVVG 271

  Fly   311 GGMTARL 317
            ||..:||
Human   272 GGTPSRL 278

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10672	NP_647946.1	NADB_Rossmann	67..317	CDD:304358	131/251 (52%)
CG10672	NP_647946.1	fabG	67..316	CDD:235975	131/250 (52%)
DHRS4	NP_066284.2	CR_SDR_c	23..278	CDD:187641	132/254 (52%)
		fabG	30..273	CDD:235975	128/242 (53%)
		Microbody targeting signal	276..278		0/1 (0%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	238	1.000	Domainoid score	I2300
eggNOG	1	0.900	-	-		E2759_KOG0725
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H49646
Inparanoid	1	1.050	260	1.000	Inparanoid score	I3114
Isobase	1	0.950	-	0.772507	Normalized mean entropy	S1637
OMA	1	1.010	-	-		QHG57783
OrthoDB	1	1.010	-	-		D1194344at2759
OrthoFinder	1	1.000	-	-		FOG0000019
OrthoInspector	1	1.000	-	-		otm40894
orthoMCL	1	0.900	-	-		OOG6_102796
Panther	1	1.100	-	-	LDO	PTHR43943
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2055
SonicParanoid	1	1.000	-	-		X181
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.820