DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10672 and DHRS2

DIOPT Version :9

Sequence 1:	NP_647946.1	Gene:	CG10672 / 38598	FlyBaseID:	FBgn0035588	Length:	317	Species:	Drosophila melanogaster
Sequence 2:	NP_878912.1	Gene:	DHRS2 / 10202	HGNCID:	18349	Length:	300	Species:	Homo sapiens

Alignment Length:	210	Identity:	108/210 - (51%)
Similarity:	143/210 - (68%)	Gaps:	1/210 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly    53 RLSSSSQSSTAGTMKRLAGKVAVVTASTDGIGFAIAKRLAEDGAAVVISSRKQKNVDSALAELRK 117
            |||....|:.......||.:|||||.||.|||||||:|||.|||.||||||||:|||.|:|:|:.
Human    18 RLSVRMSSTGIDRKGVLANRVAVVTGSTSGIGFAIARRLARDGAHVVISSRKQQNVDRAMAKLQG 82

  Fly   118 LNLNVHGLKCHVSEPEDRKQLFEETISKFGKLNILVSNAATNPAVGGVLECDEKVWDKIFDVNVK 182
            ..|:|.|:.|||.:.|||:||..:.:...|.::.||.:|..||.||..|...|::||||..||||
Human    83 EGLSVAGIVCHVGKAEDREQLVAKALEHCGGVDFLVCSAGVNPLVGSTLGTSEQIWDKILSVNVK 147

  Fly   183 SSYLLAKEALPLLRQQKNSSIVFVSSIAGYDAFELLGAYSVSKTALIGLTKAAAKDLAPEGIRVN 247
            |..||..:.||.: :.:..:::.|||||.|:....||.|:||||||:|||:..|.:|||:.||||
Human   148 SPALLLSQLLPYM-ENRRGAVILVSSIAAYNPVVALGVYNVSKTALLGLTRTLALELAPKDIRVN 211

  Fly   248 CLAPGVIRTKFSKAL 262
            |:.||:|:|.|||.:
Human   212 CVVPGIIKTDFSKVV 226

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10672	NP_647946.1	NADB_Rossmann	67..317	CDD:304358	104/196 (53%)
CG10672	NP_647946.1	fabG	67..316	CDD:235975	104/196 (53%)
DHRS2	NP_878912.1	SDR	27..>226	CDD:330230	104/199 (52%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165140621
Domainoid	1	1.000	238	1.000	Domainoid score	I2300
eggNOG	1	0.900	-	-		E2759_KOG0725
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	260	1.000	Inparanoid score	I3114
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57783
OrthoDB	1	1.010	-	-		D1194344at2759
OrthoFinder	1	1.000	-	-		FOG0000019
OrthoInspector	1	1.000	-	-		otm40894
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR43943
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2055
SonicParanoid	1	1.000	-	-		X181
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	14	13.900