Protein Alignment Gdap1 and GDAP1

DIOPT Version :10

• Sequence 1: NP_647945.1
• Gene: Gdap1 / 38597
• FlyBaseID: FBgn0035587
• Length: 327
• Species: Drosophila melanogaster
• Sequence 2: NP_061845.2
• Gene: GDAP1 / 54332
• HGNCID: 15968
• Length: 358
• Species: Homo sapiens
• Alignment Length: 343
• Identity: 99/343 - (28%)
• Similarity: 162/343 - (47%)
• Gaps: 25/343 - (7%)

  Fly     1 MSEQTKEIEALPPTLQDFKAPDLPANKPVLFFHPYNFHAQKVLMVFYEKKIDFFPYVVDLCNGEQ 65
            |:|:.:|....||...:.|| |... |.:|:...::|.:|||.:|..||.:....:.|.|...|.
Human     1 MAERQEEQRGSPPLRAEGKA-DAEV-KLILYHWTHSFSSQKVRLVIAEKALKCEEHDVSLPLSEH 63

  Fly    66 YSNWFLNLNPKGDVPVLQDGALVIPSSTHIINYVESKFRGDRS--LKPAHNSKEFDQMLIFEQAM 128
            ...||:.||..|:||||..|..:|..:|.||:|:|..|..:|:  |.|...|..:.::..:.:.:
Human    64 NEPWFMRLNSTGEVPVLIHGENIICEATQIIDYLEQTFLDERTPRLMPDKESMYYPRVQHYRELL 128

  Fly   129 ARLPVGTLSLGSFIHDDLKLVPKAPFIGPVR-QSCLKNNEKVLDLLRHSVDEQATKKAALQHKLD 192
            ..||:...:.|..:|.:|.:....|.....| :|.:.|.|..|..|.....:......|.|.:|.
Human   129 DSLPMDAYTHGCILHPELTVDSMIPAYATTRIRSQIGNTESELKKLAEENPDLQEAYIAKQKRLK 193

  Fly   193 IQLRRHE----LASSREEFQKVLDAVRHFLLYVEQELTAQAPRVEWLTGDELSVADISLGLLLHR 253
            .:|..|:    |....:|.:||||.|...|....:| |.:..:..||.|:..::||:||.:.|||
Human   194 SKLLDHDNVKYLKKILDELEKVLDQVETELQRRNEE-TPEEGQQPWLCGESFTLADVSLAVTLHR 257

  Fly   254 LYQLGFENQFWTFGKLPQVEAYFLRFRQRESFHR------------LQPSNFAILREMWTRTPGN 306
            |..|||..:.|..||.|.:|.|:.|..:|::|::            :.|:.|.:.::...:..|.
Human   258 LKFLGFARRNWGNGKRPNLETYYERVLKRKTFNKVLGHVNNILISAVLPTAFRVAKKRAPKVLGT 322

  Fly   307 ---YKLGAGAGFLGMAMF 321
               ..|.||.|:....:|
Human   323 TLVVGLLAGVGYFAFMLF 340

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Gdap1	NP_647945.1	GstA	30..297	CDD:440390	84/285 (29%)
		GST_C_family	178..285	CDD:470672	37/110 (34%)
GDAP1	NP_061845.2	GST_N_GDAP1	26..98	CDD:239350	26/71 (37%)
		GST_C_GDAP1	179..289	CDD:198336	37/110 (34%)
		Required for mitochondrial localization	320..358		6/21 (29%)