DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Fitm and fitm2

DIOPT Version :9

Sequence 1:	NP_729053.2	Gene:	Fitm / 38596	FlyBaseID:	FBgn0035586	Length:	480	Species:	Drosophila melanogaster
Sequence 2:	NP_001018334.1	Gene:	fitm2 / 552928	ZFINID:	ZDB-GENE-050508-5	Length:	252	Species:	Danio rerio

Alignment Length:	265	Identity:	85/265 - (32%)
Similarity:	133/265 - (50%)	Gaps:	57/265 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   135 LYLGSL-FVISVIGDFVP----FPKTYFARSDNLFNQYFVKIGWGWTLLFVVPFLVLSAYTITCG 194
            :||..| |.||::|..:.    .|::||:.|.|:.|.||||:.||||::.::||:..|.:.|.
Zfish    24 IYLPHLFFCISLVGSVLKNAELVPESYFSSSRNVLNLYFVKVSWGWTIVLLLPFIAYSNFYIK-- 86

  Fly   195 DHKRMLRHHFPRIVIATFFWFFWTKLFNVVENSYGRC-------TTKG-YATKSSCLKAGHLWKG 251
            .|...|| ....:::||..|:..|:.|..:|:..|.|       ..:| :.||::|.|||..|.|
Zfish    87 SHMFALR-RLTSLLVATLVWYICTETFFYIEDITGSCYESNTMVVIRGEFDTKAACRKAGFFWDG 150

  Fly   252 FDISGHAFILIHSSLVLIEEARPIIRWETIKEHIRNERHNRSTAENSGTNPLRTLNEEQMRSLQF 316
            ||||||:|||.:||||::||..|::       ||:....|
Zfish   151 FDISGHSFILSYSSLVIMEEMVPML-------HIQPAYRN------------------------- 183

  Fly   317 LYKRLTPIIRTLFIGMAALQLLWDIMLVGTMLYYHRMIEKVISGIIAILTWYFTYRFWYP---TP 378
                  |.:..|::.:..:..:|..|...|.:|:|.:|:|::.....||.||.||:.||.   :|
Zfish   184 ------PPLDCLYLALNVIVAIWIWMFGCTSVYFHDIIDKILGTSCGILGWYMTYKVWYVKLFSP 242

  Fly   379 GLLPE 383
            ||.|:
Zfish   243 GLPPQ 247

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fitm	NP_729053.2	Scs3p	157..371	CDD:287263	68/221 (31%)
fitm2	NP_001018334.1	Scs3p	55..232	CDD:287263	66/217 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170593680
Domainoid	1	1.000	104	1.000	Domainoid score	I6691
eggNOG	1	0.900	-	-		E1_KOG3750
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H35254
Inparanoid	1	1.050	136	1.000	Inparanoid score	I4550
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1621925at2759
OrthoFinder	1	1.000	-	-		FOG0001836
OrthoInspector	1	1.000	-	-		oto39636
orthoMCL	1	0.900	-	-		OOG6_105238
Panther	1	1.100	-	-	LDO	PTHR23129
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1295
SonicParanoid	1	1.000	-	-		X5529
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	14	13.830