Protein Alignment Fitm and FITM1

DIOPT Version :10

• Sequence 1: NP_729053.2
• Gene: Fitm / 38596
• FlyBaseID: FBgn0035586
• Length: 480
• Species: Drosophila melanogaster
• Sequence 2: NP_981947.1
• Gene: FITM1 / 161247
• HGNCID: 33714
• Length: 292
• Species: Homo sapiens
• Alignment Length: 325
• Identity: 86/325 - (26%)
• Similarity: 136/325 - (41%)
• Gaps: 69/325 - (21%)

  Fly    89 GPDITRSEARGTRPTAAPTSIREILVMGVIHLCKKTIFFNTDLKVALYLGS----------LFVI 143
            ||.:......|.|..|....:.::|    :.:....::|.:: :.|..|||          |..:
Human     4 GPVVGAGLGAGARIQALLGCLLKVL----LWVASALLYFGSE-QAARLLGSPCLRRLYHAWLAAV 63

  Fly   144 SVIGDFVPF---PKTYFARSDNLFNQYFVKIGWGWTLLFVVPFLVLSAYTITCGDHKR--MLRHH 203
            .:.|..:.|   |:|.||...|.||..||...||||..|:..|::|..:..|    :|  :...|
Human    64 VIFGPLLQFHVNPRTIFASHGNFFNIKFVNSAWGWTCTFLGGFVLLVVFLAT----RRVAVTARH 124

  Fly   204 FPRIVIATFFWFFWTKLFNVVENSYGRC---TTKG-----YATKSSCLKAGHLWKGFDISGHAFI 260
            ..|:|:....|....:.|.::|:..|.|   ..:|     ...:.|||.|||.|:|:.:|.|.|:
Human   125 LSRLVVGAAVWRGAGRAFLLIEDLTGSCFEPLPQGLLLHELPDRRSCLAAGHQWRGYTVSSHTFL 189

  Fly   261 LIHSSLVLIEEARPIIRWETIKEHIRNERHNRSTAENSGTNPLRTLNEEQMRSLQFLYKRLTPII 325
            |....|::.|||....::..         |......     |||         |.||       :
Human   190 LTFCCLLMAEEAAVFAKYLA---------HGLPAGA-----PLR---------LVFL-------L 224

  Fly   326 RTLFIGMAALQLLWDIMLVGTMLYYHRMIEKVISGIIAILTWYFTYRFWYPTPGLLPEAPGNGSF 390
            ..|.:|      ||:.:|:.|::|:|:...||:...:....||.||..||..| ..|.:||:|.|
Human   225 NVLLLG------LWNFLLLCTVIYFHQYTHKVVGAAVGTFAWYLTYGSWYHQP-WSPGSPGHGLF 282

  Fly   391  390
            Human   283  282

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Fitm	NP_729053.2	Scs3p	156..371	CDD:402051	60/224 (27%)
FITM1	NP_981947.1	Scs3p	80..264	CDD:402051	60/223 (27%)