DRSC/TRiP Functional Genomics Resources

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Protein Alignment AlaRS-m and AARS2

DIOPT Version :9

Sequence 1:NP_523932.2 Gene:AlaRS-m / 38595 FlyBaseID:FBgn0028962 Length:1012 Species:Drosophila melanogaster
Sequence 2:NP_065796.2 Gene:AARS2 / 57505 HGNCID:21022 Length:985 Species:Homo sapiens


Alignment Length:1048 Identity:358/1048 - (34%)
Similarity:510/1048 - (48%) Gaps:158/1048 - (15%)


- Green bases have known domain annotations that are detailed below.


  Fly    14 AREIRKTFLDHFTVNHGHKFVRSSPVVPFCDPTVAFVNAGMNQFKSVFLGTA-----AAPHKRVV 73
            |..:|..||:.|...|||:.|.|:.|.|..||::.||||||||||.:||||.     .|..:||.
Human    39 ASAVRAAFLNFFRDRHGHRLVPSASVRPRGDPSLLFVNAGMNQFKPIFLGTVDPRSEMAGFRRVA 103

  Fly    74 NSQKCVRVGGKHNDLSVVGTDGYHHTFFEMLGNWSF-GDYFKREACAMALELLRGPYNIDPGRLY 137
            |||||||.||.||||..||.|..|||||||||||:| |:|||.|||.||.|||...|.|...||:
Human   104 NSQKCVRAGGHHNDLEDVGRDLSHHTFFEMLGNWAFGGEYFKEEACNMAWELLTQVYGIPEERLW 168

  Fly   138 VTYFAGDKVLGIPADLECFEIWRSLGFPASRILPFGCADNFWEMGATGPCGPCTEIHIDHRPDLG 202
            ::||.||...|:..|||..:||.|||.||||:|.||..:||||||.|||||||||||.|....:|
Human   169 ISYFDGDPKAGLDPDLETRDIWLSLGVPASRVLSFGPQENFWEMGDTGPCGPCTEIHYDLAGGVG 233

  Fly   203 SVEQRAKLVNAGRSDLTELWNLVFIQYNRHADGSISQLPAHHVDTGMGFERLTAVLQNKSSNYDT 267
            :.:            |.|||||||:|:||.||||:..||..|||||||.|||.||||.|.|.|||
Human   234 APQ------------LVELWNLVFMQHNREADGSLQPLPQRHVDTGMGLERLVAVLQGKHSTYDT 286

  Fly   268 DLFTPIFDGIQQAAKTPVYSG--SFPDGGNAAVLDTSYRILADHARMVTACLADGMLPDQNQK-- 328
            |||:|:.:.|||..:.|.|.|  ...|.|..   ||:||::|||.|.::.|::||:.|..:..  
Human   287 DLFSPLLNAIQQGCRAPPYLGRVGVADEGRT---DTAYRVVADHIRTLSVCISDGIFPGMSGPPL 348

  Fly   329 -LRRVLRKALNISEHVF-AHDKLLTQLVPIVVETLGEAYPEMAAKQQAVIDLICHEQEVYKNLRE 391
             |||:||:|:..|..:. |....|..|||:||||||:||||:......:.:|:..::..:....|
Human   349 VLRRILRRAVRFSMEILKAPPGFLGSLVPVVVETLGDAYPELQRNSAQIANLVSEDEAAFLASLE 413

  Fly   392 SSSKAFAEVLMEFPNLDDIDLMECPGFVPAYRELQMQRCKFSNNTIPGDFLYKLTDTYGLTEESF 456
            ...:.....|.   .|...|:.      ||.....:..|  .:..:|.|.:..:.:..|:..:| 
Human   414 RGRRIIDRTLR---TLGPSDMF------PAEVAWSLSLC--GDLGLPLDMVELMLEEKGVQLDS- 466

  Fly   457 LKLAELENMNCDLERYRAEVSLAKLKAKGNQRETAGGSLCDLATEQRIAEAQAMLTKRLTPTDNS 521
               |.||.:..:..::||.      :|:..|::   |...|:   ..:.|.|   .:.:.|||:|
Human   467 ---AGLERLAQEEAQHRAR------QAEPVQKQ---GLWLDV---HALGELQ---RQGVPPTDDS 513

  Fly   522 HKYTYSFDKESDSYQIPPLKTRVLGMLLND--AEVSRTQGSRIQQPFTDLISIVTAGSNFYYESG 584
            .||.||. :.|.||:....:.:||.:...|  |..|..:|.|        ..::...:|||.|.|
Human   514 PKYNYSL-RPSGSYEFGTCEAQVLQLYTEDGTAVASVGKGQR--------CGLLLDRTNFYAEQG 569

  Fly   585 GQQSDGGKILVSNHQQPDHPHS-LDVIGVKHLNDCVVHICKLSSPTDAFQLAIGDEVELQVDAQQ 648
            ||.||.|.::.:..:....|.: ..|.|...|::.|...|          |.:||:|:|.||...
Human   570 GQASDRGYLVRAGQEDVLFPVARAQVCGGFILHEAVAPEC----------LRLGDQVQLHVDEAW 624

  Fly   649 RQLNTCHHTATHLLNAAIRSLFKKVTYQVSSSVSSDQCKLELGLLGKRIQKTDVQL--IEDLINR 711
            |......||||||||.|:|......|.|..|.::.:|.:|:   :..:...|..||  :|:.:..
Human   625 RLGCMAKHTATHLLNWALRQTLGPGTEQQGSHLNPEQLRLD---VTTQTPLTPEQLRAVENTVQE 686

  Fly   712 VICSAAPV---EVQLLSAAEVLEQNDITMVPG-----EVYPEQGLRLVNVESP-----------E 757
            .:.....|   ||.|...|:         |||     ||||:. :|:|:|..|           .
Human   687 AVGQDEAVYMEEVPLALTAQ---------VPGLRSLDEVYPDP-VRVVSVGVPVAHALDPASQAA 741

  Fly   758 LQLSSKELCCGTHATNTSELSCFCIVNLKQTNRARFAFTAVAGQAAENVLKTAALLRHRVDLLEK 822
            || :|.|||||||...|..:....|:..:|.::......||.|:.|:...:....|...|     
Human   742 LQ-TSVELCCGTHLLRTGAVGDLVIIGDRQLSKGTTRLLAVTGEQAQQARELGQSLAQEV----- 800

  Fly   823 QFQTDKLTNATEAELQTIRHNMLHTDI----------KLPYAFKMDTLERITEMLKRIKDSSRTT 877
            :..|::|:..:....:.:|   |..||          .:|...:.:.|..: :||:|   .:.|.
Human   801 KAATERLSLGSRDVAEALR---LSKDIGRLIEAVETAVMPQWQRRELLATV-KMLQR---RANTA 858

  Fly   878 LKEFVDVEMRTLLQEKPLDTH---PFILHYITSSALVEEIPLQRATKLC---PDRPILVISVCDS 936
            :::....:.....||. |:.|   |.|:..:::.:|...:.:.|  :||   |...:|::|. ..
Human   859 IRKLQMGQAAKKTQEL-LERHSKGPLIVDTVSAESLSVLVKVVR--QLCEQAPSTSVLLLSP-QP 919

  Fly   937 VVKARC-CVPEKCITEKFNASAWLQSFADTFNGQIAAPKGQNPQAVCNMKGRRVSNLFEEQLEQA 1000
            :.|..| |...:.....|.|.||..:......|     |....:.|....|...      .||.|
Human   920 MGKVLCACQVAQGAMPTFTAEAWALAVCSHMGG-----KAWGSRVVAQGTGSTT------DLEAA 973

  Fly  1001 MSKAHAYA 1008
            :|.|..||
Human   974 LSIAQTYA 981

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
AlaRS-mNP_523932.2 PLN02900 13..1010 CDD:215487 358/1048 (34%)
AlaRS_core 14..261 CDD:238360 145/252 (58%)
tRNA_SAD 570..>667 CDD:298782 33/97 (34%)
tRNA_SAD 748..>784 CDD:197931 16/46 (35%)
AARS2NP_065796.2 tRNA-synt_2c 46..983 CDD:332954 356/1041 (34%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165143759
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG0013
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG60684
OrthoDB 1 1.010 - - D129373at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR11777
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
87.820

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