DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment AlaRS-m and aars1

DIOPT Version :9

Sequence 1:	NP_523932.2	Gene:	AlaRS-m / 38595	FlyBaseID:	FBgn0028962	Length:	1012	Species:	Drosophila melanogaster
Sequence 2:	NP_001037775.1	Gene:	aars1 / 324940	ZFINID:	ZDB-GENE-030131-3663	Length:	991	Species:	Danio rerio

Alignment Length:	1062	Identity:	358/1062 - (33%)
Similarity:	512/1062 - (48%)	Gaps:	150/1062 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 AKQLQRVLTAREIRKTFLDHFTVNHGHKFVRSSPVVPFCDPTVAFVNAGMNQFKSVFLGTAAAPH 69
            |..:...|||.:||:.|:|.|. .|.|::|.||..:|..|||:.|.||||||||.:||.|....|
Zfish    23 ATSMDSSLTAAQIREKFIDFFR-RHEHQYVHSSATIPLDDPTLLFANAGMNQFKPIFLNTIDPSH 86

  Fly    70 -----KRVVNSQKCVRVGGKHNDLSVVGTDGYHHTFFEMLGNWSFGDYFKREACAMALELLRGPY 129
                 :|..|:|||:|.|||||||..||.|.||||||||||:||||||||..||.||||||...:
Zfish    87 PMARLRRAANTQKCIRAGGKHNDLDDVGKDVYHHTFFEMLGSWSFGDYFKHLACKMALELLTQEF 151

  Fly   130 NIDPGRLYVTYFAGDKVLGIPADLECFEIWRSLGFPASRILPFGCADNFWEMGATGPCGPCTEIH 194
            .|...|||||||.|....|:..||||.:||..||...|||||....|||||||.|||||||:|||
Zfish   152 GIPIERLYVTYFGGHADAGLEPDLECKQIWLDLGMEESRILPGSMKDNFWEMGDTGPCGPCSEIH 216

  Fly   195 IDHRPDLGSVEQRAKLVNAGRSDLTELWNLVFIQYNRHADGSISQLPAHHVDTGMGFERLTAVLQ 259
            .|.   :|. ...|.|||....::.|:|||||||:||.::..:..||...:|||||.|||.:|||
Zfish   217 YDR---IGG-RDAAHLVNMDDPNVLEIWNLVFIQFNRESETVLKPLPKKSIDTGMGLERLVSVLQ 277

  Fly   260 NKSSNYDTDLFTPIFDGIQQAAKTPVYSGSF----PDGGNAAVLDTSYRILADHARMVTACLADG 320
            ||.||||||||.|.|:.||:......|:|..    .||     :|.:||:||||||.:|..|:||
Zfish   278 NKMSNYDTDLFVPYFEAIQKGTGARAYTGKVGAEDTDG-----IDMAYRVLADHARTITIALSDG 337

  Fly   321 MLPDQNQK---LRRVLRKALNISEHVFAHDKLLTQ------LVPIVVETLGEAYPEMAAKQQAVI 376
            ..||...:   |||:||:|:.     ::|:||..|      ||.:||::||:|:||:......|.
Zfish   338 GRPDNTGRGYVLRRILRRAVR-----YSHEKLGAQRGFFASLVDVVVKSLGDAFPELRKDPDMVK 397

  Fly   377 DLICHEQEVYKNLRESSSKAFAEVLMEFPNLDDIDLMECPGFVPAYRELQMQRCKFSNNTIPGDF 441
            |:| :|:|.          .|.:.|.....:.|             |::|...   .:.|||||.
Zfish   398 DII-NEEEA----------QFLKTLSRGRRILD-------------RKIQSLG---ESTTIPGDT 435

  Fly   442 LYKLTDTYGLTEESFLKLAELENMNCDLERYRAEVSLAKLKAKGNQRETAGGSLCDLATEQRIAE 506
            .:.|.||||...:....:||...|..||..:..|...|:||::|.........:.|      |..
Zfish   436 AWLLYDTYGFPLDLTALIAEERGMGVDLLAFEEEKKAAQLKSQGKGSGDEDHIMLD------IYA 494

  Fly   507 AQAMLTKRLTPTDNSHKYTYSFDKESDSYQIPPLKTRVLGMLLNDAEVSRTQGSRIQQPFTDLI- 570
            ...:..|.:..||:|.||.|:.| ::.:|:.......||.:             |.::.|.|.:
Zfish   495 IDELRNKGVAATDDSPKYKYTSD-DNGNYEFEQAVGTVLAL-------------RRERMFVDEVI 545

  Fly   571 -----SIVTAGSNFYYESGGQQSDGGKILVSNHQQPDHPHSLDVIGVKHLNDCVVHICKLSSPTD 630
                 .::...::||.|.|||..|.|.:|..|....|. ....|...:.....|:||     .|.
Zfish   546 TGQECGVLLDKTSFYAEQGGQSFDEGYMLRENDSAEDR-MEFTVKNTQVRGGYVLHI-----GTV 604

  Fly   631 AFQLAIGDEVELQVDAQQRQLNTCHHTATHLLNAAIRSLFKKVTYQVSSSVSSDQCKLELGLLGK 695
            ...|.:||.:.|.||..:|:....:|||||:||..:||:..:.. |..|.|:.|  :|......|
Zfish   605 YGTLKVGDRLTLHVDEARRRPIMSNHTATHILNYGLRSVLGEAD-QRGSLVAPD--RLRFDFTAK 666

  Fly   696 RIQKTD-VQLIEDLINRVICSA-------APVEVQLLSAAEVLEQNDITMVPGEVYPEQGLRLVN 752
            ....|| |:..|::...:|..|       ||     |:||:.::  .:..|..|.||:. :|:|:
Zfish   667 GAMSTDEVRRTEEIAAAMIADAKGVYALDAP-----LAAAKAIQ--GLRAVFDETYPDP-VRVVS 723

  Fly   753 V-----------ESPELQLSSKELCCGTHATNTSELSCFCIVNLKQTNRARFAFTAVAGQAAENV 806
            :           .||...|:|.|.|.|||..|:|..:.|.||:.:...:......||.|..|:..
Zfish   724 IGVPVEELLADPNSPAGSLTSIEFCGGTHLQNSSHAAPFVIVSEEAIAKGIRRIVAVTGAEAQKA 788

  Fly   807 LKTAALLRHRVDLLEKQFQTDKLTNA-TEAELQTIRHNMLHTDIKLPYAFKMDTLERITEMLKRI 870
            .:.|..|:..:|.|.::.:...:.|. .:.|:..:..::....|.   .::.|.:....:.||:|
Zfish   789 QRKADALKLSLDALAEKVKAQSIPNKDVQKEIADMTESLGTAVIS---QWRKDEMRESLKGLKKI 850

  Fly   871 KDSSRTTLKEFVDVEMRTLLQEKPL----DTHPFILHYITS----SALVEEIPLQRATKLCPDRP 927
            .|......|  .||:.|.|.:.|.:    ...|.|:..:.|    .||.|.:.:.:...  |...
Zfish   851 MDDLDRASK--ADVQKRVLEKTKEIIDSNPNQPLIVMEMESGASAKALNESLKMLKTNS--PQTA 911

  Fly   928 ILVISVCDSVVKARC-C-VPEKCITEKFNASAWLQSFADTFNGQIAAPKGQNPQAVCNMKGRRVS 990
            .::.:|.:...|..| | ||:........||.|:|......:|     ||..........||..
Zfish   912 AMLFTVDNDAGKIICLCQVPQDVANRGLKASEWVQEVCPLLDG-----KGGGKDMSAQATGRNT- 970

  Fly   991 NLFEEQLEQAMSKAHAYAKLYL 1012
                :.:::|:..|..:|:|.|
Zfish   971 ----QCIQEALQLASEFARLKL 988

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AlaRS-m	NP_523932.2	PLN02900	13..1010	CDD:215487	354/1050 (34%)
		AlaRS_core	14..261	CDD:238360	139/251 (55%)
		tRNA_SAD	570..>667	CDD:298782	30/102 (29%)
		tRNA_SAD	748..>784	CDD:197931	15/46 (33%)
aars1	NP_001037775.1	PLN02900	31..984	CDD:215487	353/1048 (34%)
		AlaRS_core	32..279	CDD:238360	139/251 (55%)
		tRNA_SAD	719..777	CDD:285247	16/57 (28%)
		DHHA1	911..982	CDD:280440	17/80 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0013
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG60684
OrthoDB	1	1.010	-	-		D129373at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11777
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	7	6.930