Protein Alignment AlaRS-m and Aars2

DIOPT Version :10

• Sequence 1: NP_523932.2
• Gene: AlaRS-m / 38595
• FlyBaseID: FBgn0028962
• Length: 1012
• Species: Drosophila melanogaster
• Sequence 2: XP_006244575.1
• Gene: Aars2 / 301254
• RGDID: 1310617
• Length: 1057
• Species: Rattus norvegicus
• Alignment Length: 1114
• Identity: 365/1114 - (32%)
• Similarity: 511/1114 - (45%)
• Gaps: 219/1114 - (19%)

  Fly    17 IRKTFLDHFTVNHGHKFVRSSPVVPFCDPTVAFVNAGMNQFKSVFLGTA-----AAPHKRVVNSQ 76
            :|..||..|...|||:.|.|:.|.|..||::.||||||||||.:||||.     .|..:||.|||
  Rat    37 VRDAFLSFFRDRHGHRLVPSASVRPRGDPSLLFVNAGMNQFKPIFLGTVDPRSEMAGFRRVANSQ 101

  Fly    77 KCVRVGGKHNDLSVVGTDGYHHTFFEMLGNWSF-GDYFKREACAMALELLRGPYNIDPGRLYVTY 140
            ||||.||:||||..||.|..|||||||||||:| |:|||:|||:||.|||...|.|...||:|:|
  Rat   102 KCVRAGGRHNDLEDVGRDLSHHTFFEMLGNWAFGGEYFKKEACSMAWELLTQVYGIPEDRLWVSY 166

  Fly   141 FAGDKVLGIPADLECFEIWRSLGFPASRILPFGCADNFWEMGATGPCGPCTEIHIDHRPDLGSVE 205
            |:||...|:..|||..:||.|||.||||:|.||..:||||||.|||||||||||.|....:|..:
  Rat   167 FSGDSKTGLDPDLETRDIWLSLGVPASRVLSFGLQENFWEMGDTGPCGPCTEIHYDLAGGMGPPQ 231

  Fly   206 QRAKLVNAGRSDLTELWNLVFIQYNRHADGSISQLPAHHVDTGMGFERLTAVLQNKSSNYDTDLF 270
                        |.|||||||:|:.|.||||:..||..|||||||.|||.||||.|.|.||||||
  Rat   232 ------------LVELWNLVFMQHYREADGSLHLLPQQHVDTGMGLERLVAVLQGKHSTYDTDLF 284

  Fly   271 TPIFDGIQQAAKTPVYSG--SFPDGGNAAVLDTSYRILADHARMVTACLADGMLPDQNQK---LR 330
            :|:.|.|.|:.:.|.|||  ...|.|.   :||:||::|||.|.::.|:|||:.|..:..   ||
  Rat   285 SPLLDAIHQSCRVPPYSGRVGAADEGR---IDTAYRVVADHIRTLSVCIADGVSPGMSGAPLVLR 346

  Fly   331 RVLRKALNISEHVF-AHDKLLTQLVPIVVETLGEAYPEMAAKQQAVIDLICHEQEVYKNLRESSS 394
            |:||:|:..|..|. |....|..|||:||.|||.||||:......:.:|:..::..:....:...
  Rat   347 RILRRAVRYSTEVLQAPPGFLGNLVPVVVATLGAAYPELQKNSVKIANLVSEDEAAFLASLQRGR 411

  Fly   395 KAFAEVLMEFPNLDDIDLMECPGFVPAYRELQMQRCKFSNNTIPGDFLYKLTDTYGLTEESFLKL 459
            :.....:   ..|...||.      ||  |:........|..||.|.:..:.:..|:.    |..
  Rat   412 RIIDRTV---KRLGPSDLF------PA--EVAWSLSLSGNLGIPLDLVQLMLEEKGVK----LDT 461

  Fly   460 AELENMNCDLERYRAEVSLAKLKAKGNQRETAGGSLCDLATEQRIAEAQAMLTKRLTPTDNSHKY 524
            |.||.:.....::||:      :|:..|.|    .||     ..:...:.:..:.:..||:|.||
  Rat   462 AGLEQLAQKEAQHRAQ------QAEAAQEE----GLC-----LDVHALEELHRQGIPTTDDSPKY 511

  Fly   525 TYSFDKESDSYQIPPLKTRVLGML--LNDAEVSRTQGSRIQQPFTDLISIVTAGSNFYYESGGQQ 587
            .||.....| |:....:.:||.:.  ...|..|..:|.|        ..::...:|||.|.|||.
  Rat   512 NYSLRPNGD-YEFGLCEAQVLQLYSETGTAVASVGEGQR--------CGLLLDRTNFYAEQGGQA 567

  Fly   588 SDGGKILVSNHQQPDHPHS-LDVIGVKHLNDCVVHICKLSSPTDAFQLAIGDEVELQVDAQQRQL 651
            ||.|.::.:..|....|.: ..|.|...|::.:...|          |.:||.|:|.||...|..
  Rat   568 SDRGYLIRTGQQDVLFPVARAQVCGGFILHEAMAPEC----------LQVGDRVQLYVDKAWRMG 622

  Fly   652 NTCHHTATHLLNAAIRSLFKKVTYQVSSSVSSDQCKLELGLLGKRIQKTDVQL--IEDLINRVIC 714
            ....||||||||.|:|......|.|..|.::.::.:.:   :..:...|..||  :|..:...:.
  Rat   623 CMVKHTATHLLNWALRQTLGPTTEQRGSHLNPERLRFD---VATQTPLTTEQLRTVESYVQEAVG 684

  Fly   715 SAAPV---EVQLLSAAEVLEQNDITMVPG-----EVYPEQGLRLVNVESPELQL----------S 761
            ...||   ||.|...|.         :||     ||||:. :|:|:|..|..|.          :
  Rat   685 QDKPVYMEEVPLAHTAR---------IPGLRSLDEVYPDP-VRVVSVGVPVAQALAPASQAALQT 739

  Fly   762 SKELCCGTHATNTSELSCFCIVNLKQTNRARFAFTAVAGQAAENVLKTAALLRHRV--------- 817
            |.|||||||..:|..:....|:..:|..:......|:.|:.|:...:....|...|
  Rat   740 SVELCCGTHLLSTGAVGDLVIIGDRQLVKGITRLLAITGEQAQQAREVGQSLSQEVEVASERLSR 804

  Fly   818 ---DLLE-KQFQTD--KLTNATEA---------ELQT---IRHNMLHTDIKLPYAFKMD------ 858
               |||| .:...|  :|...||:         |.||   :.....:|.|:     |::
  Rat   805 GSRDLLEAHRLSKDIGRLIEFTESAVIPQWQRQEQQTTLKMLQRRANTAIR-----KLEKSQQPR 864

  Fly   859 -TLERITEMLKRIK------DSSRT----------TLKEFVD-------------------VEMR 887
             ..:||.|..:..|      :||||          .|..|::                   :::|
  Rat   865 GPCDRIEEPRQSQKATDATQESSRTRQSPAHHLSSELMAFMERASMGGRGLSGWVSVQKWNIQLR 929

  Fly   888 TLL----------QEKPLDTH---PFILHYITSSALVEEIPLQRATKLC---PDRPILVIS--VC 934
            .|.          .::.|..|   |.|:..:::.:|...:.:.|  :||   |...:|::|  ..
  Rat   930 PLCCSSAPQATEKSQELLKRHSEGPLIVDTVSAQSLSVLVKVVR--QLCKQAPSMSVLLLSPQPT 992

  Fly   935 DSVVKARCCVPEKCITEKFNASAWLQSFADTFNGQIAAPKGQNPQAVCNMKGRRVSNLFEEQLEQ 999
            .||:.|  |...:..|..|.|.||..:......|     |......:....|...      .||.
  Rat   993 GSVLCA--CQVAQGATPTFTAEAWALAVCSHMGG-----KAWGSPVIAQGTGHTA------DLEA 1044

  Fly  1000 AMSKAHAYA 1008
            |:..|.|||
  Rat  1045 ALRTARAYA 1053

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
AlaRS-m	NP_523932.2	PLN02900	13..1010	CDD:215487	365/1114 (33%)
Aars2	XP_006244575.1	PLN02900	34..1055	CDD:215487	365/1114 (33%)