DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment AlaRS-m and Cdc23

DIOPT Version :9

Sequence 1:	NP_523932.2	Gene:	AlaRS-m / 38595	FlyBaseID:	FBgn0028962	Length:	1012	Species:	Drosophila melanogaster
Sequence 2:	NP_001094129.1	Gene:	Cdc23 / 291689	RGDID:	1304819	Length:	597	Species:	Rattus norvegicus

Alignment Length:	385	Identity:	63/385 - (16%)
Similarity:	128/385 - (33%)	Gaps:	140/385 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly   361 LGEAYPEMAAKQQAVIDLICHEQEVYKNLRE----SSSKAFAEVLMEFPNLDDIDLMECPGFVPA 421
            |...|.|:...::|:        :.|::|.:    .||...:::.:.:.|:.|||..     :..
  Rat   234 LAHIYTELQLIEEAL--------QKYQHLIDVGFSKSSYIVSQIAVAYHNIRDIDKA-----LSI 285

  Fly   422 YRELQMQRCKFSNNTIPGDFLYKLTDTYGLTE-ESFLKLAELENMN----------CDLERYRAE 475
            :.||:.|                  |.|.:.. ::|..|..:.:|.          |::::||.|
  Rat   286 FNELRKQ------------------DPYRIENMDTFSNLLYVRSMKSELSYLAHNLCEIDKYRVE 332

  Fly   476 VSLAKLKAKGNQRETAGGSLCDLATEQRIAEAQAMLTKRLTP------TDNSHKYTYSFDKESDS 534
            .....            |:...|.::...|........:|.|      |...|:|   .:.::.|
  Rat   333 TCCVI------------GNYYSLRSQHEKAALYFQRALKLNPRYLGAWTLMGHEY---MEMKNTS 382

  Fly   535 YQIPPLKTRVLGMLLNDAEVSRTQ-------GSR---IQQPFTDLISIVTAGSNFYYESGGQ-QS 588
            ..|...:..:        ||::..       |..   ::.||..|         :||....| :.
  Rat   383 AAIQAYRHAI--------EVNKRDYRAWYGLGQTYEILKMPFYCL---------YYYRRAHQLRP 430

  Fly   589 DGGKILVSNHQQPDHPHSLDVIGVKHLNDCVVHICKLSSPTDAF--QLAIGDEVELQV------- 644
            :..::||:                  |.:|...:.:|......:  ..|:||..::.:
  Rat   431 NDSRMLVA------------------LGECYEKLNQLVEAKKCYWRAYAVGDVEKMALVKLAKLH 477

  Fly   645 ----DAQQ---------RQLNTCHHTATHL-LNAAIRSL----FKKVTYQVSSSVSSDQC 686
                :::|         :.:.:|..|..|| .:.|.|.|    ||...:..:|:.:...|
  Rat   478 EQLTESEQAAQCYIKYIQDIYSCGETVEHLEESTAFRYLAQYYFKCKLWDEASTCAQKCC 537

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AlaRS-m	NP_523932.2	PLN02900	13..1010	CDD:215487	63/385 (16%)
		AlaRS_core	14..261	CDD:238360
		tRNA_SAD	570..>667	CDD:298782	17/120 (14%)
		tRNA_SAD	748..>784	CDD:197931
Cdc23	NP_001094129.1	ANAPC8	45..148	CDD:397937
		TPR repeat	172..197	CDD:276809
		TPR repeat	202..257	CDD:276809	6/30 (20%)
		TPR	216..451	CDD:223533	48/297 (16%)
		TPR repeat	263..291	CDD:276809	7/32 (22%)
		TPR repeat	331..359	CDD:276809	4/39 (10%)
		TPR repeat	367..393	CDD:276809	5/36 (14%)
		TPR repeat	398..428	CDD:276809	6/38 (16%)
		TPR repeat	433..461	CDD:276809	5/45 (11%)
		TPR repeat	467..495	CDD:276809	1/27 (4%)
		TPR repeat	501..536	CDD:276809	9/34 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0013
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900