DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment AlaRS-m and ala1

DIOPT Version :9

Sequence 1:	NP_523932.2	Gene:	AlaRS-m / 38595	FlyBaseID:	FBgn0028962	Length:	1012	Species:	Drosophila melanogaster
Sequence 2:	NP_593640.1	Gene:	ala1 / 2542031	PomBaseID:	SPAC23C11.09	Length:	959	Species:	Schizosaccharomyces pombe

Alignment Length:	1048	Identity:	337/1048 - (32%)
Similarity:	494/1048 - (47%)	Gaps:	171/1048 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 AREIRKTFLDHFTVNHGHKFVRSSPVVPFCDPTVAFVNAGMNQFKSVFLGTA-----AAPHKRVV 73
            |.|||:|||.:|. :|||..|.||.|:|:.|||:.|.||||||||.:||||.     .|..||..
pombe    12 ANEIRRTFLKYFE-DHGHTIVPSSSVIPYDDPTLLFANAGMNQFKPIFLGTVDPSSDFAKLKRAC 75

  Fly    74 NSQKCVRVGGKHNDLSVVGTDGYHHTFFEMLGNWSFGDYFKREACAMALELLRGPYNIDPGRLYV 138
            :||||:|.|||||||..||.|.||||.||||||||||||||:||.|||.:||...|.:...:|||
pombe    76 DSQKCIRAGGKHNDLEDVGKDNYHHTMFEMLGNWSFGDYFKKEAIAMAWDLLTNVYGLKKDQLYV 140

  Fly   139 TYFAGDKVLGIPADLECFEIWRSLGFPASRILPFGCADNFWEMGATGPCGPCTEIHIDHRPDLGS 203
            |||.|.:..|:..|||..::|..:|...||::|....|||||||..||||||:|||.|.   :|:
pombe   141 TYFGGHEESGLEPDLEARQLWLDIGIDESRVIPGSLKDNFWEMGDQGPCGPCSEIHYDR---IGN 202

  Fly   204 VEQRAKLVNAGRSDLTELWNLVFIQYNRHADGSISQLPAHHVDTGMGFERLTAVLQNKSSNYDTD 268
             ....:|||....::.|:||:||||:||..|||:..||..|||||||||||.:|:|||:||||||
pombe   203 -RTVPELVNMDDPNVLEIWNIVFIQFNREKDGSLRPLPNRHVDTGMGFERLVSVIQNKTSNYDTD 266

  Fly   269 LFTPIFDGIQQAAKTPVYSGSFPDGGNAAVLDTSYRILADHARMVTACLADGMLPDQNQK---LR 330
            :|:|||..||:......|:|...| .:...:||:||::|||.|.:|..::||.:|:...:   ||
pombe   267 VFSPIFAKIQELTNARPYTGKMGD-EDVDGIDTAYRVVADHVRTLTFAISDGGVPNNEGRGYVLR 330

  Fly   331 RVLRKALNISEHVFAHDKLLTQLVPI----------VVETLGEAYPEMAAKQQAVIDLICHEQEV 385
            |:||:........|.        |||          |||.:|:.:||:..|...|.:|:..|:|.
pombe   331 RILRRGARYVRKKFG--------VPIGNFFSRLSLTVVEQMGDFFPELKRKVDDVRELLDEEEES 387

  Fly   386 YKNLRESSSKAFAEVLMEFPNLDDIDLMECPGFVPAYRELQMQRCKFSNNTIPGDFLYKLTDTYG 450
            :....:...|.|.:                  :..|.:       |..:.|:.|:.:::|.:|||
pombe   388 FSRTLDRGEKMFEQ------------------YAAAAK-------KTPSKTLQGNDVWRLYETYG 427

  Fly   451 LTEESFLKLAELENMNCDLERYRAEVSLAKLKAKGNQRETAGGSLCDLATEQRIAEAQAM--LTK 513
            ...:....:||...:..|...:  |.:.|:.|....|....|.|..||.    :.:..|:  |:|
pombe   428 FPVDLTHLMAEEAGIKIDEPGF--EAAQARSKEISKQASKGGSSGDDLL----VLDVHALGALSK 486

  Fly   514 R--LTPTDNSHKYTY--------------SFDKESDSYQIPPLKTRVLGMLLNDAEVSRTQGSRI 562
            .  :..||:..|:..              .|.|.::.:.    ....||:||:     ||
pombe   487 MDDIPETDDVFKHNSVSLKSVIKGIYHKGGFQKSTEGFN----SGEQLGLLLD-----RT----- 537

  Fly   563 QQPFTDLISIVTAGSNFYYESGGQQSDGGKILVSNHQQPDHPHSLDVIGVKHLNDCVVHICKLSS 627
                           |||.|.|||:.|.|.|::      |......|..|:.....|:|...|
pombe   538 ---------------NFYAEQGGQEYDTGHIVI------DGVADFRVTNVQVYAGYVLHTGFL-- 579

  Fly   628 PTDAFQLAIGDEVELQVDAQQRQLNTCHHTATHLLNAAIRSLFKKVTYQVSSSVSSDQCKLELGL 692
              :...|.:.|.|..:.|..:|.....:||.||:||.|:|:.......|..|.||.::.:.:...
pombe   580 --EYGNLTVNDSVVCEYDEIRRWHLMNNHTVTHILNLALRNTLGDGIDQRGSLVSQEKLRFDFSY 642

  Fly   693 LGKRIQKTDVQLIEDLINRVI---CSAAPVEVQLLSAAEVLEQNDITMVPGEVYPEQGLRLVNV- 753
            ... |....:.|:|:..|.||   .|....||.|..|.|:   |.:..|.|||||:. :|:|.:
pombe   643 KSS-IPIDKLLLVENYCNNVIQDNLSVYSKEVALSKAKEI---NGLRAVFGEVYPDP-VRVVCIG 702

  Fly   754 ----------ESPELQLSSKELCCGTHATNTSELSCFCIVNLKQTNRARFAFTAVAGQAAENVLK 808
                      :.|:....|.|.|.|||...:.|:..|.|:......:......||....|..|.:
pombe   703 VDIDTLLQEPKKPDWTKYSIEFCGGTHCDKSGEIKDFVILEENGIAKGIRRIVAVTSTEANRVSR 767

  Fly   809 TAALLRHRVDLLEKQFQTDKLTNATEAELQTIRHNMLHTDIKLPYAFKMDTLERITEMLKRIKDS 873
            .|.....|:..|||.    ..:.|.||||:.|..::  :.:.:....|....|||.::.|::::.
pombe   768 LANEFDARIAKLEKM----PFSPAKEAELKKISVDL--SKLVVAAVRKHAMKERIAKITKQVQEH 826

  Fly   874 ----SRTTLKEFVDV---------EMRTLLQEKPLDTHPFILHYITSSALVEEIPLQRATKLCPD 925
                :....||.|:|         :|..::.:.|:..:|..|.:          .|..|.|...|
pombe   827 VKAINAAEQKEVVNVVTEYFKENPDMSFVVAKVPISANPKALSF----------ALTYAKKNLKD 881

  Fly   926 RPILVISVCDSVVKARCCVPEKCITEKFNASAWLQSFADTFNGQIAAPKGQNPQAVCNMKGRRVS 990
            :.|.:::..|:.|...|.|..:.: :|.....|.|....:..|: :..||...|.|.: |...:.
pombe   882 KSIYLLASDDTKVAHACLVSPEAM-KKLTPQEWSQKVCHSIGGR-SGGKGDTCQGVGD-KPLSID 943

  Fly   991 NLFEEQLE 998
            ...||.:|
pombe   944 VAVEEAIE 951

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AlaRS-m	NP_523932.2	PLN02900	13..1010	CDD:215487	337/1048 (32%)
		AlaRS_core	14..261	CDD:238360	140/251 (56%)
		tRNA_SAD	570..>667	CDD:298782	28/96 (29%)
		tRNA_SAD	748..>784	CDD:197931	12/46 (26%)
ala1	NP_593640.1	PLN02900	3..952	CDD:215487	337/1048 (32%)
		AlaRS_core	12..259	CDD:238360	140/251 (56%)
		tRNA_SAD	532..739	CDD:298782	66/246 (27%)
		DHHA1	881..951	CDD:280440	17/72 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0013
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG60684
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11777
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	6	5.880