Protein Alignment AlaRS-m and Aars1

DIOPT Version :10

• Sequence 1: NP_523932.2
• Gene: AlaRS-m / 38595
• FlyBaseID: FBgn0028962
• Length: 1012
• Species: Drosophila melanogaster
• Sequence 2: NP_666329.2
• Gene: Aars1 / 234734
• MGIID: 2384560
• Length: 968
• Species: Mus musculus
• Alignment Length: 1074
• Identity: 374/1074 - (34%)
• Similarity: 522/1074 - (48%)
• Gaps: 180/1074 - (16%)

  Fly     8 LQRVLTAREIRKTFLDHFTVNHGHKFVRSSPVVPFCDPTVAFVNAGMNQFKSVFLGTAAAPH--- 69
            :...|||||||:.|::.|..|. |.:|.||..:|..|||:.|.||||||||.:||.|....|
Mouse     1 MDATLTAREIRERFINFFRRNE-HTYVHSSATIPLDDPTLLFANAGMNQFKPIFLNTIDPSHPMA 64

  Fly    70 --KRVVNSQKCVRVGGKHNDLSVVGTDGYHHTFFEMLGNWSFGDYFKREACAMALELLRGPYNID 132
              .|..|:|||:|.|||||||..||.|.||||||||||:||||||||..||.||||||...:.|.
Mouse    65 KLSRAANTQKCIRAGGKHNDLDDVGKDVYHHTFFEMLGSWSFGDYFKELACKMALELLTQEFGIP 129

  Fly   133 PGRLYVTYFAGDKVLGIPADLECFEIWRSLGFPASRILPFGCADNFWEMGATGPCGPCTEIHIDH 197
            ..|||||||.||:..|:..||||.:||::||...:||||....|||||||.|||||||:|||.|.
Mouse   130 VERLYVTYFGGDEAAGLEPDLECRQIWQNLGLDEARILPGNMKDNFWEMGDTGPCGPCSEIHYDR 194

  Fly   198 RPDLGSVEQRAKLVNAGRSDLTELWNLVFIQYNRHADGSISQLPAHHVDTGMGFERLTAVLQNKS 262
               :|. ...|.|||....::.|:||||||||||.:||.:..||...:|||||.|||.:|||||.
Mouse   195 ---IGG-RDAAHLVNQDDPNVLEIWNLVFIQYNRESDGVLKPLPKKSIDTGMGLERLVSVLQNKM 255

  Fly   263 SNYDTDLFTPIFDGIQQAAKTPVYSGSF----PDGGNAAVLDTSYRILADHARMVTACLADGMLP 323
            ||||||||.|.|:.||:......|:|..    .||     :|.:||:||||||.:|..||||..|
Mouse   256 SNYDTDLFMPYFEAIQKGTGARPYTGKVGAEDADG-----IDMAYRVLADHARTITVALADGGRP 315

  Fly   324 DQNQK---LRRVLRKALNISEHVFAHDKL------LTQLVPIVVETLGEAYPEMAAKQQAVIDLI 379
            |...:   |||:||:|:.     ::|:||      ...||.:||::||:|:||:....:.|.|:|
Mouse   316 DNTGRGYVLRRILRRAVR-----YSHEKLNASRGFFATLVDVVVQSLGDAFPELKKDPEMVKDII 375

  Fly   380 CHEQEVYKNLRESSSKAFAEVLMEFPNLDDIDLMECPGFVPAYRELQ-MQRCKFSNNTIPGDFLY 443
             :|:||          .|.:.|.....:.|             |::| :..||    |||||..:
Mouse   376 -NEEEV----------QFLKTLSRGRRILD-------------RKIQSLGDCK----TIPGDTAW 412

  Fly   444 KLTDTYGLTEESFLKLAELENMNCDLERYRAEVSLAKLKAKGNQRETAGGSLCDLATEQRIAEAQ 508
            .|.||||...:....:||.:.:..|:..:..|..||:||::|   :.||.....:.....|.|.:
Mouse   413 LLYDTYGFPVDLTGLIAEEKGLVVDMNGFEEERRLAQLKSQG---KGAGDEDLIMLDIYAIEELR 474

  Fly   509 AMLTKRLTPTDNSHKYTYSFDKESDSYQIPPLKTRVLGMLLNDAEVSRTQGSRIQQPFTDLI--- 570
            |   |.|..||:|.||.|..| .|.||........||.:             |.::.|.|.:
Mouse   475 A---KGLEATDDSPKYNYQSD-SSGSYVFECTVATVLAL-------------RREKMFVDEVVTG 522

  Fly   571 ---SIVTAGSNFYYESGGQQSDGGKILVSNHQQPDHPHSLDVIGVKHLNDCVVHICKLSSPTDAF 632
               .:|...:.||.|.|||..|.| .||......:......|...:.....|:||..:..
Mouse   523 QECGVVLDKTCFYAEQGGQIYDEG-YLVKVDDSSEDKTEFTVKNAQVRGGYVLHIGTIYG----- 581

  Fly   633 QLAIGDEVELQVDAQQRQLNTCHHTATHLLNAAIRSLFKKVTYQVSSSVSSDQCKLELGLLGKRI 697
            .|.:||:|.|.:|..:|:....:|||||:||.|:||:..:.. |..|.|:.|:.:.:....| .:
Mouse   582 NLKVGDQVRLFIDEPRRRPVMSNHTATHILNFALRSVLGEAD-QKGSLVAPDRLRFDFTAKG-AM 644

  Fly   698 QKTDVQLIEDLINRVICSAAPVEVQ--LLSAAEVLEQNDITMVPGEVYPEQGLRLVNVESP--EL 758
            ....::..|:::|.:|.:|.||..|  .|:||:.::  .:..|..|.||:. :|:|::..|  ||
Mouse   645 STQQIKKAEEIVNGMIEAAKPVYTQDCPLAAAKAIQ--GLRAVFDETYPDP-VRVVSIGVPVSEL 706

  Fly   759 ---------QLSSKELCCGTHATNTSELSCFCIVNLKQTNRARFAFTAVAGQAAENVLKTAALLR 814
                     .|:|.|.|.|||..|:|....|.||..:...:......||.|..|:..|:.:..|:
Mouse   707 LDDPCGPAGSLTSVEFCGGTHLRNSSHAGAFVIVTEEAIAKGIRRIVAVTGAEAQKALRKSETLK 771

  Fly   815 HRVDLLEKQFQTDKLTNATEAELQTIRHNMLHTDIKLPYAFKMDTLERITEMLKRI--------- 870
                         |..:|.||:            :|...|...|....|.::.:.:
Mouse   772 -------------KSLSAMEAK------------VKAQTAPNKDVQREIADLGEALATAVIPQWQ 811

  Fly   871 KDSSRTTLKEF------------VDVEMRTLLQEKPL----DTHPFILHYITSSALVEEIPLQRA 919
            ||..|.|||..            .||:.|.|.:.|.|    ...|.::..:.|.|..:  .|..|
Mouse   812 KDEQRETLKSLKKVMDDLDRASKADVQKRVLEKTKQLIDSNPNQPLVILEMESGASAK--ALNEA 874

  Fly   920 TKL----CPDRPILVISVCDSVVKARC-C-VPEKCITEKFNASAWLQSFADTFNGQIAAPKGQNP 978
            .||    .|....::.:|.:...|..| | ||:........||.|:|..:...:|     ||...
Mouse   875 LKLFKTHSPQTSAMLFTVDNEAGKITCLCQVPQNAANRGLKASEWVQQVSGLMDG-----KGGGK 934

  Fly   979 QAVCNMKGRRVSNLFEEQLEQAMSKAHAYAKLYL 1012
            .......|:.|.     .|::|:..|.::|:|.|
Mouse   935 DMSAQATGKNVG-----CLQEALQLATSFAQLRL 963

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
AlaRS-m	NP_523932.2	PLN02900	13..1010	CDD:215487	371/1065 (35%)
Aars1	NP_666329.2	PLN02900	6..961	CDD:215487	371/1065 (35%)
		Nuclear localization signal. /evidence=ECO:0000255|HAMAP-Rule:MF_03133	750..763		4/12 (33%)