Protein Alignment AlaRS-m and Aars2

DIOPT Version :10

• Sequence 1: NP_523932.2
• Gene: AlaRS-m / 38595
• FlyBaseID: FBgn0028962
• Length: 1012
• Species: Drosophila melanogaster
• Sequence 2: NP_941010.2
• Gene: Aars2 / 224805
• MGIID: 2681839
• Length: 980
• Species: Mus musculus
• Alignment Length: 1051
• Identity: 353/1051 - (33%)
• Similarity: 504/1051 - (47%)
• Gaps: 170/1051 - (16%)

  Fly    17 IRKTFLDHFTVNHGHKFVRSSPVVPFCDPTVAFVNAGMNQFKSVFLGTA-----AAPHKRVVNSQ 76
            :|..||..|...|||:.|.|:.|.|..||::.||||||||||.:||||.     .|..:||||||
Mouse    37 VRDAFLSFFRDRHGHRLVPSATVRPRGDPSLLFVNAGMNQFKPIFLGTVDPRSEMAGFRRVVNSQ 101

  Fly    77 KCVRVGGKHNDLSVVGTDGYHHTFFEMLGNWSF-GDYFKREACAMALELLRGPYNIDPGRLYVTY 140
            ||||.||:||||..||.|..|||||||||||:| |:|||.|||:||.|||...|.|...||:|:|
Mouse   102 KCVRAGGRHNDLEDVGRDLSHHTFFEMLGNWAFGGEYFKEEACSMAWELLTQVYGIPEDRLWVSY 166

  Fly   141 FAGDKVLGIPADLECFEIWRSLGFPASRILPFGCADNFWEMGATGPCGPCTEIHIDHRPDLGSVE 205
            |:||...|:..|||..:||.|||.||||:|.||..:||||||.|||||||||||.|....:||.:
Mouse   167 FSGDSQTGLDPDLETRDIWLSLGVPASRVLSFGPQENFWEMGDTGPCGPCTEIHYDLAGGVGSPQ 231

  Fly   206 QRAKLVNAGRSDLTELWNLVFIQYNRHADGSISQLPAHHVDTGMGFERLTAVLQNKSSNYDTDLF 270
                        |.|||||||:|:.|.||||:..||..|||||||.|||.||||.|.|.||||||
Mouse   232 ------------LVELWNLVFMQHYREADGSLQLLPQRHVDTGMGLERLVAVLQGKRSTYDTDLF 284

  Fly   271 TPIFDGIQQAAKTPVYSG--SFPDGGNAAVLDTSYRILADHARMVTACLADGMLPDQNQK---LR 330
            :|:.|.|.|:...|.|||  ...|.|.   :||:||::|||.|.::.|:|||:.|..:..   ||
Mouse   285 SPLLDAIHQSCGAPPYSGRVGAADEGR---IDTAYRVVADHIRTLSVCIADGVSPGMSGAPLVLR 346

  Fly   331 RVLRKALNISEHVF-AHDKLLTQLVPIVVETLGEAYPEMAAKQQAVIDLICHEQEVYKNLRESSS 394
            |:||:|:..|..|. |....|..|||:||||||.||||:......:..|:..::..:....:...
Mouse   347 RILRRAVRYSTEVLQAPPGFLGSLVPVVVETLGSAYPELEKNSVKIASLVSEDEAAFLASLQRGR 411

  Fly   395 KAFAEVLMEFPNLDDIDLMECPGFVPAYRELQMQRCKFSNNTIPGDFLYKLTDTYGLTEESFLKL 459
            :.....:   ..|...||.      ||  |:........|..||.|.:..:.:..|:.    |..
Mouse   412 RIIDRTV---KRLGPSDLF------PA--EVAWSLSLSGNLGIPLDLVELMLEEKGVK----LDT 461

  Fly   460 AELENMNCDLERYRAEVSLAKLKAKGNQRETAGGSLCDLATEQRIAEAQAMLTKRLTPTDNSHKY 524
            |.||.:.....::||:      :|:.:|.:    .||     ..:...:.:..:.:..||:|.||
Mouse   462 AGLEQLAQKEAQHRAQ------QAEADQED----RLC-----LDVHALEELHRQGIPTTDDSPKY 511

  Fly   525 TYSFDKESDSYQIPPLKTRVLGML--LNDAEVSRTQGSRIQQPFTDLISIVTAGSNFYYESGGQQ 587
            .|:.....| |:....:.|||.:.  ...|..|...|.|        ..::...:|||.|.|||.
Mouse   512 NYTLHPNGD-YEFGLCEARVLQLYSETGTAVASVGAGQR--------CGLLLDRTNFYAEQGGQA 567

  Fly   588 SDGGKILVSNHQQPDHPHSLDVIGVKHLNDCVVHICKLSSPTDAFQLAIGDEVELQVDAQQRQLN 652
            ||.|.::.:..|....|    |.|.:.....::|  :..:|.   :|.:||:|:|.||...|...
Mouse   568 SDRGYLVRTGQQDMLFP----VAGAQLCGGFILH--EAMAPE---RLQVGDQVQLYVDKAWRMGC 623

  Fly   653 TCHHTATHLLNAAIRSLFKKVTYQVSSSVSSDQCKLELGLLGKRIQKTD-VQLIEDLINRVICSA 716
            ...|||||||:.|:|......|.|..|.::.::.:.::..  :.:..|: ::.:|..:..|:...
Mouse   624 MVKHTATHLLSWALRQTLGPTTEQRGSHLNPERLRFDVAT--QTLLTTEQLRTVESYVQEVVGQD 686

  Fly   717 APV---EVQLLSAAEVLEQNDITMVPG-----EVYPEQGLRLVNVESPELQL----------SSK 763
            .||   ||.|...|.         :||     ||||:. :|:|:|..|....          :|.
Mouse   687 KPVFMEEVPLAHTAR---------IPGLRSLDEVYPDP-VRVVSVGVPVAHALGPASQAAMHTSV 741

  Fly   764 ELCCGTHATNTSELSCFCIVNLKQTNRARFAFTAVAGQAAENVLKTAALLRHRVDLLEKQFQTDK 828
            |||||||..:|..:....|:..:|..:......|:.|:.|:...:....|...|:.
Mouse   742 ELCCGTHLLSTGAVGDLVIIGERQLVKGITRLLAITGEQAQQAREVGQSLSQEVEA--------- 797

  Fly   829 LTNATEAELQTIRHNMLHTDIKLPYAFKMD-TLERITEM-----------------LKRIKDSSR 875
               |:|...|..|        .||.|.::. .:.|:||:                 ||.::..:.
Mouse   798 ---ASERLSQGSR--------DLPEAHRLSKDIGRLTEVAESAVIPQWQRQELQTTLKMLQRRAN 851

  Fly   876 TTLKEFVDVEMRTLLQEKPLDTH---PFILHYITSSALVEEIPLQRATKLCPDRP---ILVIS-- 932
            |.::: ::....|...::.|..|   |.|:..:::.:|...:.:.|  :||...|   :|::|
Mouse   852 TAIRK-LEKGQATEKSQELLKRHSEGPLIVDTVSAESLSVLVKVVR--QLCKQAPSISVLLLSPQ 913

  Fly   933 VCDSVVKARCCVPEKCITEKFNASAWLQSFADTFNGQIAAPKGQNPQAVCNMKGRRVSNLFEEQL 997
            ...||:.|  |...:..|..|.|.||..:......|     |....:.|....|...      .|
Mouse   914 PTGSVLCA--CQVAQDATPTFTAEAWALAVCSHMGG-----KAWGSRVVAQGTGHTA------DL 965

  Fly   998 EQAMSKAHAYA 1008
            |.|:..|.|||
Mouse   966 EAALGTARAYA 976

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
AlaRS-m	NP_523932.2	PLN02900	13..1010	CDD:215487	353/1051 (34%)
Aars2	NP_941010.2	PLN02900	34..978	CDD:215487	353/1051 (34%)