DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment AlaRS-m and mat-3

DIOPT Version :9

Sequence 1:	NP_523932.2	Gene:	AlaRS-m / 38595	FlyBaseID:	FBgn0028962	Length:	1012	Species:	Drosophila melanogaster
Sequence 2:	NP_497203.1	Gene:	mat-3 / 175205	WormBaseID:	WBGene00003134	Length:	673	Species:	Caenorhabditis elegans

Alignment Length:	461	Identity:	96/461 - (20%)
Similarity:	159/461 - (34%)	Gaps:	146/461 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   201 LGSVEQRAKLVNAGRSDLTELW------NLVFIQYNRH--ADGSISQLPAHHVDTGM-GFER-LT 255
            :..:|...|.|.:  :::..||      .||..::::|  |.....||    |..|| |... :|
Worm   278 IADIEDADKFVTS--AEVKSLWMGDWFMTLVLQRFHQHSMAIQKAEQL----VTRGMTGLPMIIT 336

  Fly   256 AVLQNKSSNYDTDLFTPIFDGIQQAAKTPVYSGSFPDGGNAAVLDTSYRILADHARMVTACLADG 320
            .:....::.:|.|.....|:.:::|....:        |:..:|..|..|..|..::.|..:
Worm   337 KIAACSNARHDHDQAISNFEDVRKADPYRL--------GDLHLLSDSLYIRNDQKKLSTLAI--- 390

  Fly   321 MLPDQNQKLRRVLRKALNI----------SEHVFAHDKLLTQLVPIVVETLGEAYPEMAAKQQAV 375
                :..|:.:...:...|          |||.....:...:|.|      |.|         |:
Worm   391 ----EVYKVHKFRWETCCIVANYHAIRRDSEHAIKFFQRALRLNP------GLA---------AL 436

  Fly   376 IDLICHEQEVYKNLRESSSKAFAEV----LMEFPNLDD---------IDLMECPGFVPAYRELQM 427
            ..||.||      ..|..:.|.|.|    .:|....|.         .|:|:.|.:...|.: :.
Worm   437 WVLIGHE------FMEMKNNAAACVSYRRAIEIDPADHRGWYGLGQMYDIMKMPAYALFYYQ-EA 494

  Fly   428 QRCKFSNNTIPGD--FLYKLTDTYGLTEESFLKLAELENM-NCDLERY-------RAEVSLAKLK 482
            |:||      |.|  .|..|.|.|.       ||..:|:. .|....|       .|..|||||.
Worm   495 QKCK------PHDSRLLVALGDIYS-------KLNRIEDAEKCFTGAYLFGDVEGNALWSLAKLH 546

  Fly   483 AKGNQRETAGGS------LCDLAT--EQRIAEAQAMLTKRLTPTDNSHKYTYSFDKESDSYQIPP 539
            .:.:....|..:      :.:|.|  |::|..|.|.|.......::       |||.|:
Worm   547 ERYSDDNKAAQAFEVFLVVYELVTSAEEKIIYAIAFLANHFFKIED-------FDKASE------ 598

  Fly   540 LKTRVLGMLLNDAEVSRTQGSRIQQPFTDLISIVTAGSNFYYE----------SGGQQS------ 588
            ..|:.|..     |....:|:|:   |.::..|....|....|          :|||::
Worm   599 YATKCLAF-----ETLCQEGNRL---FREIAKIQARESRLPVEEAPGPSNASAAGGQEAMDTEEA 655

  Fly   589 --DGGK 592
              :||:
Worm   656 PQEGGE 661

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AlaRS-m	NP_523932.2	PLN02900	13..1010	CDD:215487	96/461 (21%)
		AlaRS_core	14..261	CDD:238360	16/69 (23%)
		tRNA_SAD	570..>667	CDD:298782	8/41 (20%)
		tRNA_SAD	748..>784	CDD:197931
mat-3	NP_497203.1	TPR repeat	401..428	CDD:276809	4/26 (15%)
		TPR_11	434..499	CDD:290150	19/86 (22%)
		TPR repeat	434..462	CDD:276809	10/42 (24%)
		TPR repeat	467..497	CDD:276809	6/30 (20%)
		TPR_11	471..528	CDD:290150	17/70 (24%)
		TPR repeat	502..529	CDD:276809	8/33 (24%)
		TPR repeat	577..605	CDD:276809	8/40 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0013
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900