DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment AlaRS-m and aars-1

DIOPT Version :9

Sequence 1:	NP_523932.2	Gene:	AlaRS-m / 38595	FlyBaseID:	FBgn0028962	Length:	1012	Species:	Drosophila melanogaster
Sequence 2:	NP_496444.1	Gene:	aars-1 / 174749	WormBaseID:	WBGene00000196	Length:	793	Species:	Caenorhabditis elegans

Alignment Length:	834	Identity:	262/834 - (31%)
Similarity:	391/834 - (46%)	Gaps:	147/834 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 EIRKTFLDHFTVNHGHKFVRSSPVVP-FCDPTVAFVNAGMNQFKSVFLGTAAAPHKRVVNSQKCV 79
            |:||:|.:.|. :..|:.:|||.|:| ..|.|:.|.||||||||.:.|.:..:  :||.|.|||:
Worm    26 ELRKSFYEFFK-SKNHEILRSSSVIPDENDGTLLFTNAGMNQFKPLILSSTES--RRVANIQKCI 87

  Fly    80 RVGGKHNDLSVVGTDGYHHTFFEMLGNWSFGDYF-KREACAMALELLRGPYNIDPGRLYVTYFAG 143
            |.|||||||..||.|.:|.|||||:|||||.|.| |.|||..|.|.|.....|:..||||:||.|
Worm    88 RAGGKHNDLDDVGKDLHHQTFFEMMGNWSFNDAFSKEEACRYAWEYLVEILGINADRLYVSYFGG 152

  Fly   144 DKVLGIPADLECFEIWRSLGFPASRILPFGCADNFWEMGATGPCGPCTEIHIDHRPDLGSVEQRA 208
            .:.||:|.|.||.|||:.:|..::||||| .|:|||||||.||||||||||.|.   :|. ...:
Worm   153 IEKLGLPEDRECREIWKRIGVSSNRILPF-VAENFWEMGAAGPCGPCTEIHYDR---IGG-RDAS 212

  Fly   209 KLVNAGRSDLTELWNLVFIQYNRHADGSISQLPAHHVDTGMGFERLTAVLQNKSSNYDTDLFTPI 273
            :|||...| :.|:||:||:...|.:.|.|..|..:|:|||||||||.:|:|||:||:|||:||||
Worm   213 RLVNIDDS-VVEIWNIVFMSSVRDSCGQIRHLGKNHIDTGMGFERLLSVVQNKTSNFDTDVFTPI 276

  Fly   274 FDGIQQAAKTPVYSGSFPDGGNAAVLDTSYRILADHARMVTACLADGMLPDQNQ---KLRRVLRK 335
            .:...:.||.. |:||..     :..|.::|::|||.|..|..::||.:||...   .:|:::|:
Worm   277 LEKTSELAKKQ-YTGSLD-----SRQDATFRLVADHIRAATVAISDGAVPDGTGCGFIVRKMMRR 335

  Fly   336 A-------LNISEHVFAHDKLLTQLVPIVVETLGEAYPEMAAKQQAVIDLICHEQEVYKNLRESS 393
            |       |.|..:.      :::|||:|..|:.|.|||:......:..:...|:..:....:.:
Worm   336 AFLQGISKLGIERYA------MSELVPVVASTMKEVYPEIHDTSTHIRKIFNDEEAQFWKTVDKA 394

  Fly   394 SKAFAEVLMEFPNLDDIDLMECPGFVPAYRELQMQRCKFSNNTIPGDFLYKLTDTYGLTEESFLK 458
            .|.|..|..|                            ..:..|.|...:.|.:|:||.....::
Worm   395 KKMFDSVAAE----------------------------SKSPIISGRKAFNLFETHGLPLAVTVE 431

  Fly   459 LAELENMNCDLERYRAEVSLAKLKAKGNQRETAGGSLCDLATEQRIAEAQAMLTKRLTPTD---N 520
            ||.    |...|....|....:|:|                  |::::..:.....::..|   :
Worm   432 LAR----NIGREVDETEFERCRLEA------------------QKVSQKASQFKLPISADDFPSH 474

  Fly   521 SHKYTYSFDKESDSYQIPPLKTRVLGMLLNDAEVSRTQGSRIQQPFTDLISIVTAGSNFYYESGG 585
            |.|..||:...:..|:.|.:|||:|       :|.:.|.........|...:|.....||.|.||
Worm   475 SDKEKYSYVFRNGKYEFPQVKTRIL-------QVYKDQQKAESLEANDRGFLVLEECQFYGEQGG 532

  Fly   586 QQSDGGKILVSNHQQPDHPHSLDVIGVKHLNDCVVHICKLSSPTDAFQLAI-----GDEVELQVD 645
            |.||.|.:|:...:..:..::..:.|              .:.|..|..|:     ...||.::|
Worm   533 QTSDTGHLLIDGREVFEVENAKKIAG--------------GAVTVLFGRALLPIRRDLRVEQKLD 583

  Fly   646 AQQRQLNTCHHTATHLLNAAIRSLFKKVTYQVSSSVSSDQCKLELGLLGKRIQKTDVQLIEDLIN 710
            ..:|:.....|:||||||.|::.| ...:.|..|||..|:.:.:.....:.:.|.  |..|.||.
Worm   584 ETRREGVMRAHSATHLLNWALQKL-GVGSGQKGSSVDCDRFRFDYSTGDEDLSKE--QRTELLIK 645

  Fly   711 RVICSAAPVEVQLLSAAEVLEQNDITMVPGEVYPEQGLRLVNVESP------------ELQLSS- 762
               |.        :...|.::....|.:. |...|:..::.|::|.            .:.|.|
Worm   646 ---CE--------MKMREFIQNGGFTEII-ETSLEEAKKIENLQSDVKEDRIGGASVRVVALGSG 698

  Fly   763 ----KELCCGTHATNTSELSCFCIVNLK---QTNRARFAFTAVAGQAAENVLKT 809
                .|.|.|||..:...:....|::.|   |..|.....|.....|..|..|:
Worm   699 ADVPVECCSGTHIHDVRVIDDVAIMSDKSMGQRLRRIIVLTGKEAAACRNYTKS 752

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AlaRS-m	NP_523932.2	PLN02900	13..1010	CDD:215487	262/834 (31%)
		AlaRS_core	14..261	CDD:238360	128/246 (52%)
		tRNA_SAD	570..>667	CDD:298782	27/101 (27%)
		tRNA_SAD	748..>784	CDD:197931	10/52 (19%)
aars-1	NP_496444.1	AlaRS_core	24..264	CDD:238360	128/246 (52%)
		tRNA-synt_2c	26..569	CDD:279719	216/634 (34%)
		AlaX	502..745	CDD:225427	59/271 (22%)
		tRNA_SAD	519..722	CDD:298782	52/231 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S431
OMA	1	1.010	-	-		QHG60684
OrthoDB	1	1.010	-	-		D129373at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11777
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.980