Protein Alignment AlaRS-m and aars-2

DIOPT Version :9

• Sequence 1: NP_523932.2
• Gene: AlaRS-m / 38595
• FlyBaseID: FBgn0028962
• Length: 1012
• Species: Drosophila melanogaster
• Sequence 2: NP_491281.1
• Gene: aars-2 / 171985
• WormBaseID: WBGene00000197
• Length: 968
• Species: Caenorhabditis elegans
• Alignment Length: 1055
• Identity: 343/1055 - (32%)
• Similarity: 512/1055 - (48%)
• Gaps: 153/1055 - (14%)

  Fly    12 LTAREIRKTFLDHFTVNHGHKFVRSSPVVPFCDPTVAFVNAGMNQFKSVFLGTA-----AAPHKR 71
            |||.|:|.||::.|.....|.:|.||.|:|..|||:.|.||||||||.:|||.|     .|..||
 Worm     4 LTASEVRSTFINFFREKKEHTYVHSSSVIPHDDPTLLFANAGMNQFKPLFLGIADPNSDLAKLKR 68

  Fly    72 VVNSQKCVRVGGKHNDLSVVGTDGYHHTFFEMLGNWSFGDYFKREACAMALELLRGPYNIDPGRL 136
            .||:|||:|.|||||||..||.|.||||:||||||||||||||:|....|.|||...|.|...||
 Worm    69 AVNTQKCIRAGGKHNDLDDVGKDVYHHTYFEMLGNWSFGDYFKKEIITWAWELLTTVYGIPAERL 133

  Fly   137 YVTYFAGDKVLGIPADLECFEIWRSLGFPASRILPFGCADNFWEMGATGPCGPCTEIHIDHRPDL 201
            ||:.|.||:..|:|||.|..:||||:|.|..|||.||..|||||||..||||||:|||.|.   :
 Worm   134 YVSVFGGDEANGVPADSEARDIWRSVGVPDERILNFGMKDNFWEMGDVGPCGPCSEIHYDR---I 195

  Fly   202 GSVEQRAKLVNAGRSDLTELWNLVFIQYNRHADGSISQLPAHHVDTGMGFERLTAVLQNKSSNYD 266
            |: ...:.||||....:.|:|||||||:||...|.:..|||.|:|.|:|.|||.||:|:|:||||
 Worm   196 GN-RDASHLVNADDPMVVEIWNLVFIQFNREEGGVLKPLPAKHIDCGLGLERLIAVMQDKTSNYD 259

  Fly   267 TDLFTPIFDGIQQAAKTPVYSGSFPDGGNAAVLDTSYRILADHARMVTACLADGMLPDQNQK--- 328
            ||:|.|||:.|.:.:....|:|...|.....| |.:||::|||.|.:|..|:||..||.:.:
 Worm   260 TDIFQPIFEAIHKGSGVRAYTGFIGDEDKDGV-DMAYRVVADHVRTLTIALSDGGRPDNSGRGYV 323

  Fly   329 LRRVLRKALN-ISEHVFAHDKLLTQLVPIVVETLGEAYPEMAAKQQAVIDLICHEQEVYKNLRES 392
            |||:||:.:. .||.:.|.......|||:|:..|||.:||::.....|:|:|..|::.:......
 Worm   324 LRRILRRGVRYASEKLNAQPGFFASLVPVVISILGETFPELSRDPVTVMDIINDEEKQFLKTLSR 388

  Fly   393 SSKAFAEVLMEFPNLDDIDLMECPGFVPAYRELQMQRCKFSNNTIPGDFLYKLTDTYGLTEESFL 457
            ....|...:...|.                          ...|.|||..::|.||||...:...
 Worm   389 GRVLFQRAVQSLPE--------------------------GTMTFPGDVSWRLYDTYGFPADLTQ 427

  Fly   458 KLAELENMNCD---LERYRAEVSLAKLKAKGNQRETAGGSLCDLATEQRIAEAQAMLTKRLTPTD 519
            .:||.:.::.|   .|..|.:.........|..|:|     .||.. ..:||.|   .|.:..||
 Worm   428 LMAEEKGLSVDNTAFEEARRKAIETSSAGTGKFRDT-----LDLDV-HALAELQ---QKGVPTTD 483

  Fly   520 NSHKYTYSFDKE-SDS-YQIPPLKTRVLGMLLNDAEVSRTQGSRIQQPFTDLI------SIVTAG 576
            :|.||.|:|..| ||: |:..|...::|.:        |..|.     |.|.:      :|:...
 Worm   484 DSPKYAYTFTGEGSDAVYKFEPCVGKILAI--------RRDGK-----FVDQLAAGEEGAILLDR 535

  Fly   577 SNFYYESGGQQSDGGKILVSNHQQPDHPHSLDVIGVKHLNDCVV---HICKLSSPTDAFQLAIGD 638
            :|||.|.|||..|.|.:...|.:..:.          ::::|.|   :|..:.|...:|  ::||
 Worm   536 TNFYAEQGGQIYDVGVLTKVNDESNEF----------NVSNCQVRGGYIVLVGSAEGSF--SVGD 588

  Fly   639 EVELQVDAQQRQLNTCHHTATHLLNAAIRSLFKKVTYQVSSSVSSDQCKLEL----GLLGKRIQK 699
            :|..:.|..::||...:||.||:||.|:|.:... :.|..|.|:.|:.:.:.    |:..::::|
 Worm   589 QVNERFDEDRKQLIMKNHTGTHVLNYALRKVLAD-SDQKGSLVAPDRMRFDFTNKAGMTVQQVKK 652

  Fly   700 TD--VQLIEDLINRVICSAAPVEVQLLSAAEVLEQNDITMVPGEVYPEQGLRLVNVESPELQL-- 760
            .:  .|.:.|...:|....:|:       .|..:...:..:..|.||:. :|:|.|.:|..||
 Worm   653 AEEYAQQLIDTKGQVYAKNSPL-------GEAKKVKGLRAMFDETYPDP-VRVVAVGTPVEQLLQ 709

  Fly   761 ---------SSKELCCGTHATNTSELSCFCIVNLKQTNRARFAFTAVAGQAAENVLKTAALLRHR 816
                     ::.|.|.|||..|.|.:....|.:.:...:......|:.|..||..:..|..|..|
 Worm   710 NPDAEEGQNTTVEFCGGTHLQNVSHIGRIVIASEEAIAKGIRRIVALTGPEAERAIARADRLTAR 774

  Fly   817 VDLLEKQFQTDK----LTN-----ATEAELQTIRHNMLHTDIKLPYAFKMDTLERITEMLKRIKD 872
            ::  |:....||    |.|     |.:.::|.|....  ...:||| ::.|::....:.:::..|
 Worm   775 LE--EESKHADKKDELLANKDKFKALQKKIQEIVDEA--NGAQLPY-WRKDSIREKAKAIQKTLD 834

  Fly   873 ----SSRTTLKEFVDVEMRTL--LQEKPLDTHPFILHYITSSALVEEIPLQRATKLCPD-RPILV 930
                :.:..:.|.|..|.:.|  :.|:|    ..::|...::|..:.|  ..|.||..| :.::.
 Worm   835 GYTKAQQAAVAEKVLGEAKELAAVAEQP----TVLVHVFAANANSKAI--DNALKLLKDTKAVMA 893

  Fly   931 ISVCDSVVKARCC--VPEKCITEKFNASAWLQSFADTFNGQIAAPKGQNPQAVCNMKGRRVSNLF 993
            .||.:...|..|.  |.:..::....|:.|:........|     ||....|...:.|..|
 Worm   894 FSVNEDSGKVLCLAKVDKSLVSNGLKANEWVNEVCTVLGG-----KGGGKDANAQLTGENV---- 949

  Fly   994 EEQLEQAMSKAHAYA 1008
             ::|:.|:..|..:|
 Worm   950 -DKLDAAVELAQKFA 963

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
AlaRS-m	NP_523932.2	PLN02900	13..1010	CDD:215487	342/1054 (32%)
		AlaRS_core	14..261	CDD:238360	141/251 (56%)
		tRNA_SAD	570..>667	CDD:298782	29/105 (28%)
		tRNA_SAD	748..>784	CDD:197931	14/46 (30%)
aars-2	NP_491281.1	PLN02900	5..965	CDD:215487	342/1054 (32%)
		AlaRS_core	6..254	CDD:238360	141/251 (56%)
		tRNA_SAD	530..754	CDD:298782	58/244 (24%)
		DHHA1	892..961	CDD:280440	16/78 (21%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0013
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S431
OMA	1	1.010	-	-		QHG60684
OrthoDB	1	1.010	-	-		D129373at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11777
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.880