DRSC/TRiP Functional Genomics Resources

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Protein Alignment AlaRS-m and AARS1

DIOPT Version :9

Sequence 1:NP_523932.2 Gene:AlaRS-m / 38595 FlyBaseID:FBgn0028962 Length:1012 Species:Drosophila melanogaster
Sequence 2:NP_001596.2 Gene:AARS1 / 16 HGNCID:20 Length:968 Species:Homo sapiens


Alignment Length:1053 Identity:371/1053 - (35%)
Similarity:530/1053 - (50%) Gaps:138/1053 - (13%)


- Green bases have known domain annotations that are detailed below.


  Fly     8 LQRVLTAREIRKTFLDHFTVNHGHKFVRSSPVVPFCDPTVAFVNAGMNQFKSVFLGTAAAPH--- 69
            :...|||.|||:.|:|.|..|. |.:|.||..:|..|||:.|.||||||||.:||.|....|   
Human     1 MDSTLTASEIRQRFIDFFKRNE-HTYVHSSATIPLDDPTLLFANAGMNQFKPIFLNTIDPSHPMA 64

  Fly    70 --KRVVNSQKCVRVGGKHNDLSVVGTDGYHHTFFEMLGNWSFGDYFKREACAMALELLRGPYNID 132
              .|..|:|||:|.|||||||..||.|.||||||||||:||||||||..||.||||||...:.|.
Human    65 KLSRAANTQKCIRAGGKHNDLDDVGKDVYHHTFFEMLGSWSFGDYFKELACKMALELLTQEFGIP 129

  Fly   133 PGRLYVTYFAGDKVLGIPADLECFEIWRSLGFPASRILPFGCADNFWEMGATGPCGPCTEIHIDH 197
            ..|||||||.||:..|:.|||||.:||::||...::|||....|||||||.|||||||:|||.|.
Human   130 IERLYVTYFGGDEAAGLEADLECKQIWQNLGLDDTKILPGNMKDNFWEMGDTGPCGPCSEIHYDR 194

  Fly   198 RPDLGSVEQRAKLVNAGRSDLTELWNLVFIQYNRHADGSISQLPAHHVDTGMGFERLTAVLQNKS 262
               :|. ...|.|||....::.|:||||||||||.|||.:..||...:|||||.|||.:|||||.
Human   195 ---IGG-RDAAHLVNQDDPNVLEIWNLVFIQYNREADGILKPLPKKSIDTGMGLERLVSVLQNKM 255

  Fly   263 SNYDTDLFTPIFDGIQQAAKTPVYSGSF----PDGGNAAVLDTSYRILADHARMVTACLADGMLP 323
            ||||||||.|.|:.||:......|:|..    .||     :|.:||:||||||.:|..||||..|
Human   256 SNYDTDLFVPYFEAIQKGTGARPYTGKVGAEDADG-----IDMAYRVLADHARTITVALADGGRP 315

  Fly   324 DQNQK---LRRVLRKALNISEHVFAHDKL------LTQLVPIVVETLGEAYPEMAAKQQAVIDLI 379
            |...:   |||:||:|:.     :||:||      ...||.:||::||:|:||:......|.|:|
Human   316 DNTGRGYVLRRILRRAVR-----YAHEKLNASRGFFATLVDVVVQSLGDAFPELKKDPDMVKDII 375

  Fly   380 CHEQEVYKNLRESSSKAFAEVLMEFPNLDDIDLMECPGFVPAYRELQMQRCKFSNNTIPGDFLYK 444
             :|:||          .|.:.|.....:.|             |::|...   .:.|||||..:.
Human   376 -NEEEV----------QFLKTLSRGRRILD-------------RKIQSLG---DSKTIPGDTAWL 413

  Fly   445 LTDTYGLTEESFLKLAELENMNCDLERYRAEVSLAKLKAKGNQRETAGGSLCDLATEQRIAEAQA 509
            |.||||...:....:||.:.:..|::.:..|..||:||::|   :.|||....:.....|.|.:|
Human   414 LYDTYGFPVDLTGLIAEEKGLVVDMDGFEEERKLAQLKSQG---KGAGGEDLIMLDIYAIEELRA 475

  Fly   510 MLTKRLTPTDNSHKYTYSFDKESDSYQIPPLKTRVLGMLLNDAEVSRTQGSRIQQPFTDLIS--- 571
               :.|..||:|.||.|..| .|.||             :.:..|:.....|.::.|.:.:|   
Human   476 ---RGLEVTDDSPKYNYHLD-SSGSY-------------VFENTVATVMALRREKMFVEEVSTGQ 523

  Fly   572 ---IVTAGSNFYYESGGQQSDGGKILVSNHQQPDHPHSLDVIGVKHLNDCVVHICKLSSPTDAFQ 633
               :|...:.||.|.|||..|.| .||......:......|...:.....|:||..:..     .
Human   524 ECGVVLDKTCFYAEQGGQIYDEG-YLVKVDDSSEDKTEFTVKNAQVRGGYVLHIGTIYG-----D 582

  Fly   634 LAIGDEVELQVDAQQRQLNTCHHTATHLLNAAIRSLFKKVTYQVSSSVSSDQCKLELGLLGKRIQ 698
            |.:||:|.|.:|..:|:....:|||||:||.|:||:..:.. |..|.|:.|:.:.:....| .:.
Human   583 LKVGDQVWLFIDEPRRRPIMSNHTATHILNFALRSVLGEAD-QKGSLVAPDRLRFDFTAKG-AMS 645

  Fly   699 KTDVQLIEDLINRVICSAAPVEVQ--LLSAAEVLEQNDITMVPGEVYPEQGLRLVNVESP--EL- 758
            ...::..|::.|.:|.:|..|..|  .|:||:.::  .:..|..|.||:. :|:|::..|  || 
Human   646 TQQIKKAEEIANEMIEAAKAVYTQDCPLAAAKAIQ--GLRAVFDETYPDP-VRVVSIGVPVSELL 707

  Fly   759 --------QLSSKELCCGTHATNTSELSCFCIVNLKQTNRARFAFTAVAGQAAENVLKTAALLRH 815
                    .|:|.|.|.|||..|:|....|.||..:...:......||.|..|:..|:.|..|:.
Human   708 DDPSGPAGSLTSVEFCGGTHLRNSSHAGAFVIVTEEAIAKGIRRIVAVTGAEAQKALRKAESLKK 772

  Fly   816 RVDLLEKQFQTDKLTNA-TEAELQTIRHNMLHTDIKLPYAFKMDTLERITEMLKRIKDSSRTTLK 879
            .:.::|.:.:.....|. .:.|:..: ...|.|.: :| .::.|.|....:.||::.|......|
Human   773 CLSVMEAKVKAQTAPNKDVQREIADL-GEALATAV-IP-QWQKDELRETLKSLKKVMDDLDRASK 834

  Fly   880 EFVDVEMRTLLQEKP-LDTH---PFILHYITSSALVEEIPLQRATKL----CPDRPILVISVCDS 936
              .||:.|.|.:.|. :|::   |.::..:.|.|..:  .|..|.||    .|....::.:|.:.
Human   835 --ADVQKRVLEKTKQFIDSNPNQPLVILEMESGASAK--ALNEALKLFKMHSPQTSAMLFTVDNE 895

  Fly   937 VVKARC-C-VPEKCITEKFNASAWLQSFADTFNGQIAAPKGQNPQAVCNMKGRRVSNLFEEQLEQ 999
            ..|..| | ||:........||.|:|..:...:|     ||..........|:.|.     .|::
Human   896 AGKITCLCQVPQNAANRGLKASEWVQQVSGLMDG-----KGGGKDVSAQATGKNVG-----CLQE 950

  Fly  1000 AMSKAHAYAKLYL 1012
            |:..|.::|:|.|
Human   951 ALQLATSFAQLRL 963

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
AlaRS-mNP_523932.2 PLN02900 13..1010 CDD:215487 368/1044 (35%)
AlaRS_core 14..261 CDD:238360 144/251 (57%)
tRNA_SAD 570..>667 CDD:298782 31/102 (30%)
tRNA_SAD 748..>784 CDD:197931 16/46 (35%)
AARS1NP_001596.2 PLN02900 6..961 CDD:215487 368/1044 (35%)
AlaRS_core 7..254 CDD:238360 144/251 (57%)
Translation_Factor_II_like <495..531 CDD:295476 7/48 (15%)
tRNA_SAD 525..753 CDD:298782 67/238 (28%)
DHHA1 886..955 CDD:280440 17/78 (22%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG0013
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 1 0.950 - 0 Normalized mean entropy S431
OMA 1 1.010 - - QHG60684
OrthoDB 1 1.010 - - D129373at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR11777
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
76.880

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