DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Gen and EXO1

DIOPT Version :9

Sequence 1:	NP_647943.2	Gene:	Gen / 38594	FlyBaseID:	FBgn0263831	Length:	726	Species:	Drosophila melanogaster
Sequence 2:	NP_006018.4	Gene:	EXO1 / 9156	HGNCID:	3511	Length:	846	Species:	Homo sapiens

Alignment Length:	829	Identity:	174/829 - (20%)
Similarity:	267/829 - (32%)	Gaps:	270/829 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MGVKELWGVLTPHCERKPINELRGKKVAIDLAGWV-------CESL---NVVDYFVHPRHHLKNL 55
            ||::.|...:....|...:.:.:|:.||:|...|:       .|.|   ...|.:|.......|:
Human     1 MGIQGLLQFIKEASEPIHVRKYKGQVVAVDTYCWLHKGAIACAEKLAKGEPTDRYVGFCMKFVNM 65

  Fly    56 FFRTCYLIWEQVTPVFVLEGVAPKLKSQVIAKRNELQ----------FRGVKPKNSPEC------ 104
                  |:...:.|:.|.:|.....|.:|...|.|.:          .|..|...:.||
Human    66 ------LLSHGIKPILVFDGCTLPSKKEVERSRRERRQANLLKGKQLLREGKVSEARECFTRSIN 124

  Fly   105 -TQSQPSKGDKGRSRFNHVLKQCETLLLSMGIQCVQGPGEAEAYCAFLNKHGLVDGVISQDSDCF 168
             |.:...|          |:|...    |.|:.|:..|.||:|..|:|||.|:|..:|::|||..
Human   125 ITHAMAHK----------VIKAAR----SQGVDCLVAPYEADAQLAYLNKAGIVQAIITEDSDLL 175

  Fly   169 AYGAVRVYRNFSVSTQGA---QAAAGGAVDIYDMREITSRMDFGQQKIIVMALLCGCDYCPD--G 228
            |:|..:|.........|.   ||..|....:.|:        |.::|...|.:|.||||...  |
Human   176 AFGCKKVILKMDQFGNGLEIDQARLGMCRQLGDV--------FTEEKFRYMCILSGCDYLSSLRG 232

  Fly   229 IGGIGKDGVLKLFNKYKETEILDRMRSW-----------------RGETDKY------------- 263
            ||......||:|.|.....:::.::..:                 ...|..|
Human   233 IGLAKACKVLRLANNPDIVKVIKKIGHYLKMNITVPEDYINGFIRANNTFLYQLVFDPIKRKLIP 297

  Fly   264 -NALEIRVDDKSICSNCGHIGKTQSHTKSGCSVCRTHKGCDESLWKEQRLSIKSELTLRRKALLS 327
             ||.|..||.::: |..|..                   .|:|:    .|.|         ||.:
Human   298 LNAYEDDVDPETL-SYAGQY-------------------VDDSI----ALQI---------ALGN 329

  Fly   328 PDFPNEEIIAEFLSEPDTIPNLNLNWRQPNLVKFIKQIGHLLQWPEIYCFQKFFPILTRWQVQQS 392
            .|....|.|.::  .|||....:..             .|  .|.:..| ||...:.:.|....|
Human   330 KDINTFEQIDDY--NPDTAMPAHSR-------------SH--SWDDKTC-QKSANVSSIWHRNYS 376

  Fly   393 KQEKILIQPHEIIKKRTVKGVPSLELRWHDPSGI-------FKGL-IPDKQIAEYEAEHPKGIEE 449
            .:.          :..||...|.|:   .:||.:       .||| :|.|...   .:.|:.
Human   377 PRP----------ESGTVSDAPQLK---ENPSTVGVERVISTKGLNLPRKSSI---VKRPRS--- 422

  Fly   450 LYYTIEPLDMLETAYPDLVAAFLKSKEKPAKKTTRKKKTASEEENKE------------NEPNSK 502
                      .|.:..||::.:..|       .|:|.|..|.|.||.            |.|.:|
Human   423 ----------AELSEDDLLSQYSLS-------FTKKTKKNSSEGNKSLSFSEVFVPDLVNGPTNK 470

  Fly   503 PKRVVRKIKAQPEENQPLLHQFLGRKKE--GTPVKAPAPQRQQCSTPITKFLPSDLESDCDAEEF 565
                  |..:.|...:.....||.||.|  |..|......|..||:
Human   471 ------KSVSTPPRTRNKFATFLQRKNEESGAVVVPGTRSRFFCSS------------------- 510

  Fly   566 DMSDIVKGIIS-NPNAKPALTNHDGHQLHYEPMAEDLSLRLAQMSLGNVNESPKVETKRDLSQVD 629
            |.:|.|...:| .|..:.|:|:.: :.||.....:....||....:.. |.|..:....  ...|
Human   511 DSTDCVSNKVSIQPLDETAVTDKE-NNLHESEYGDQEGKRLVDTDVAR-NSSDDIPNNH--IPGD 571

  Fly   630 QLP-------QSKRFSLEDS-FDLLV--------------KGDLQKLARTPVERFKMQHRISEKI 672
            .:|       ..:.:|.|.| |...:              .|.|...:|||             .
Human   572 HIPDKATVFTDEESYSFESSKFTRTISPPTLGTLRSCFSWSGGLGDFSRTP-------------S 623

  Fly   673 PTPVKPLDNISYFFNQSSDNADVFEELMNSSLVPQDQEDNAEDEEEDDL 721
            |:|...|..    |.:.||:.....| .|.|.|.|.:.:.:.|:|...|
Human   624 PSPSTALQQ----FRRKSDSPTSLPE-NNMSDVSQLKSEESSDDESHPL 667

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gen	NP_647943.2	PIN_GEN1	1..385	CDD:189039	96/446 (22%)
Gen	NP_647943.2	H3TH_GEN1	210..342	CDD:188625	32/164 (20%)
EXO1	NP_006018.4	fen_arch	1..308	CDD:274717	77/334 (23%)
		PIN_EXO1	1..206	CDD:189027	54/224 (24%)
		N-domain	1..99		22/103 (21%)
		Interaction with MSH3. /evidence=ECO:0000269\|PubMed:11427529	129..387		73/340 (21%)
		I-domain	138..229		33/102 (32%)
		H3TH_EXO1	213..289	CDD:188628	16/75 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	372..396		6/36 (17%)
		Interaction with MLH1	388..490		28/133 (21%)
		Nuclear localization signal	418..421		0/2 (0%)
		Interaction with MSH2	600..846		19/86 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	618..781		17/68 (25%)
		Interaction with MLH1	787..846
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0258
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810