Protein Alignment Gen and YEN1

DIOPT Version :9

• Sequence 1: NP_647943.2
• Gene: Gen / 38594
• FlyBaseID: FBgn0263831
• Length: 726
• Species: Drosophila melanogaster
• Sequence 2: NP_010959.2
• Gene: YEN1 / 856764
• SGDID: S000000843
• Length: 759
• Species: Saccharomyces cerevisiae
• Alignment Length: 869
• Identity: 161/869 - (18%)
• Similarity: 285/869 - (32%)
• Gaps: 282/869 - (32%)

  Fly     1 MGVKELWGVLTPHCE--RKPI---------NELRGKKVAIDLAGWV--CESLNVVDYFVHPRHHL 52
            |||.::|..|.|:.:  |.|:         ::.|..::|||..||:  |..:..:|.....|...
Yeast     1 MGVSQIWEFLKPYLQDSRIPLRKFVIDFNKSQKRAPRIAIDAYGWLFECGFIQNIDISARSRSRS 65

  Fly    53 K-------------------------------NLFFRTCYLIWEQVTPVFVLEGVAPKLKSQVIA 86
            :                               |...|...|:...|..:.|.:||   :|.....
Yeast    66 RSPTRSPRDSDIDSSQEYYGSRSYTTTGKAVINFISRLKELLSLNVEFLLVFDGV---MKPSFKR 127

  Fly    87 KRNELQFRGVKPKNSPECTQSQPSKGDKGRSRFNH-VLKQCETLLLS---------------MGI 135
            |.|..|       |:..|...:.......:...|| |...|:.||..               |.|
Yeast   128 KFNHEQ-------NATTCDDEKEYYSSWEQHVKNHEVYGNCKGLLAPSDPEFISLVRKLLDLMNI 185

  Fly   136 QCVQGPGEAEAYCAFLNKHGLVDGVISQDSDCFAYGAVRVYRNFSV-------------STQGAQ 187
            ..|...||.||.|.:|...|.||.::|.|||...:|..::.:|:|.             |.....
Yeast   186 SYVIACGEGEAQCVWLQVSGAVDFILSNDSDTLVFGGEKILKNYSKFYDDFGPSSITSHSPSRHH 250

  Fly   188 AAAGGAVDIYDMREI--TSRMDFGQQKIIVMALLCGCDYCPDGIGGIGKDGVLKL---------- 240
            .:....|.:.|:.:|  .:...|.:..::..::|.|.|| ..|:.|:||:..|:|
Yeast   251 DSKESFVTVIDLPKINKVAGKKFDRLSLLFFSVLLGADY-NRGVKGLGKNKSLQLAQCEDPNFSM 314

  Fly   241 --FNKYKETEILDRMRSWRGETDKYNALEIRVDDKSICSNCGHIGKTQSHTKSGCSVCRTH---- 299
              ::.:|:..:.| :.|......:|...:.|:                      ...|:.|
Yeast   315 EFYDIFKDFNLED-LTSESLRKSRYRLFQKRL----------------------YLYCKDHSVEL 356

  Fly   300 ----------KGCDESLWKEQRLSIKSELTLRR--KALLSPDFPNEEIIAEFLSEPDTIPNLNLN 352
                      :|..|. |       .|.:.:..  ..::.|.|..|.:..::::........|||
Yeast   357 FGRNYPVLLNQGSFEG-W-------PSTVAIMHYFHPIVQPYFDEEVLSDKYINMAGNGHYRNLN 413

  Fly   353 WRQPNLVKFIKQIGHLLQWPEIYCFQKFFPILTRWQVQQSKQEKILIQPHEII------------ 405
            :   |.:|:..|   .|..|:|..|.|:|        ..|..|..|::....|
Yeast   414 F---NELKYFLQ---SLNLPQISSFDKWF--------HDSMHEMFLLREFLSIDESDNIGKGNMR 464

  Fly   406 ----KKRTVKG----VPSLELRW------------------HDPSGIFKGLIPDKQIAEYEAEHP 444
                |...:.|    :|..::|:                  :.||   :...|.::..:. .|||
Yeast   465 ITEEKIMNIDGGKFQIPCFKIRYTTFLPNIPISSQSPLKRSNSPS---RSKSPTRRQMDI-MEHP 525

  Fly   445 KGIEELYYTIEPLDMLETAYPDLVAAFLKSKEKPAKKTTRKKKTASEEENKENEPNSKPKRVVRK 509
            ..:....|.|.....|...|.:......|.|||..||:.:.:
Yeast   526 NSLWLPKYLIPQSHPLVIQYYETQQLIQKEKEKKGKKSNKSR----------------------- 567

  Fly   510 IKAQPEENQPLLHQFLGRKKEGTPVKA---PAPQRQQCSTPITKFLPSDLESDCDAEEFDMSDIV 571
               .|::|.  |.:||  :|..:|:|:   ....|::...|:.|.|..|.:.|...||..
Yeast   568 ---LPQKNN--LDEFL--RKHTSPIKSIGKVGESRKEILEPVRKRLFVDTDEDTSLEEIP----- 620

  Fly   572 KGIISNPNAKPALTNHDGHQLHYEPMAEDLSL----------RLAQMSLG----NVNESPKVETK 622
                    |...||..|.|..:     :|.||          .:...|.|    ::.:..:|:..
Yeast   621 --------APTRLTTVDEHSDN-----DDDSLIFVDEITNSQSVLDSSPGKRIRDLTQDEQVDVW 672

  Fly   623 RDLSQVDQLPQSK---------RFSLEDSFDLLVKGDLQKLARTP----VERFKMQH-RISEKIP 673
            :|:.::..:.:|:         ...|:....:.:...||.....|    ..|.:.:| .:.:::.
Yeast   673 KDVIEISPIKKSRTTNAEKNPPESGLKSRSSITINARLQGTKMLPPNLTAPRLEREHSSVLDQLV 737

  Fly   674 TPVKPLDNISYFFNQSSDNADVFE 697
            |..:  |.:..|....||::...|
Yeast   738 TDAQ--DTVDRFVACDSDSSSTIE 759

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Gen	NP_647943.2	PIN_GEN1	1..385	CDD:189039	96/486 (20%)
		H3TH_GEN1	210..342	CDD:188625	24/159 (15%)
YEN1	NP_010959.2	PIN_YEN1	2..275	CDD:350218	59/282 (21%)
		H3TH_YEN1	286..388	CDD:188626	20/133 (15%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0258
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S5877
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11081
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.860