DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Gen and Gen1

DIOPT Version :9

Sequence 1:	NP_647943.2	Gene:	Gen / 38594	FlyBaseID:	FBgn0263831	Length:	726	Species:	Drosophila melanogaster
Sequence 2:	XP_006239958.1	Gene:	Gen1 / 298884	RGDID:	1559792	Length:	910	Species:	Rattus norvegicus

Alignment Length:	790	Identity:	228/790 - (28%)
Similarity:	353/790 - (44%)	Gaps:	142/790 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MGVKELWGVLTPHCERKPINELRGKKVAIDLAGWVCESLNV---VDYFVHPRHHLKNLFFRTCYL 62
            |||.:||.:|.|..:...:.:|.||.:|:||:.||||:..|   :...:.|  ||:|||||..||
  Rat     1 MGVNDLWQILEPVKQHIHLQDLCGKTIAVDLSLWVCEAQTVKKMIGTVMKP--HLRNLFFRISYL 63

  Fly    63 IWEQVTPVFVLEGVAPKLKSQVIAKRNELQFRGVKPKNSPECTQSQPSKGDKGRSRFNHVLKQCE 127
            ....|..|||:||..||||:.|:.||.:.:: |...|:..:.|         |||.|..||::|.
  Rat    64 TQMNVKLVFVMEGEPPKLKADVMNKRTQTRY-GPSGKSRSQKT---------GRSHFKSVLRECL 118

  Fly   128 TLLLSMGIQCVQGPGEAEAYCAFLNKHGLVDGVISQDSDCFAYGAVRVYRNFSVSTQGAQAAAGG 192
            .:|..:|:..||..|||||.||:||..|.|||.::.|.|.|.|||..|||||:::|:...
  Rat   119 EMLECLGMPWVQAAGEAEAMCAYLNASGHVDGCLTNDGDAFLYGAQTVYRNFTMNTKDPH----- 178

  Fly   193 AVDIYDMREITSRMDFGQQKIIVMALLCGCDYCPDGIGGIGKDGVLKLFNKYKETEILDRMRSWR 257
             ||.|.:..|.|::...:..::.:|:|.||||.|.|:.|:||:..|||....|...:|.|...|.
  Rat   179 -VDCYTVSSIKSKLGLDRDALVGLAVLLGCDYLPKGVPGVGKEQALKLLQILKGQSLLQRFNQWT 242

  Fly   258 GETDKYNALEIRVDDKSICSNCGHIGKTQSHTKSGCSVCRTHKGCD----ESL----WKE---QR 311
             |...|:..:........||.|.|.|..:.|.::||::|::.:.|:    |.|    |.:   .|
  Rat   243 -EEPGYSVPQSAAKKVVHCSVCSHPGSPKDHERNGCTLCKSDRYCEPHDYEYLCPCEWHQTDHNR 306

  Fly   312 LSIKSELTLRRKALLSPDFPNEEIIAEFLSEPDTI--PNLNLNWRQPNLVKFIKQIGHLLQWPEI 374
            ...:.|..:::||.....||..|:|.||||..:.:  |   :.:::|:|:.|.:.....::||..
  Rat   307 QLNEIENNIKKKACSCEGFPFHEVIQEFLSNKNKLLKP---IRYQRPDLLLFQRFTVQKMEWPSH 368

  Fly   375 YCFQKFFPILTRWQVQQSK---QEKILIQPHEIIKKRTVKGVPSLELRWHDPSGIFKGLIPDKQI 436
            |..:|...:|||:.:.:.|   :....:||..|:|.|...||..||:.|..|.
  Rat   369 YACEKLLVLLTRYDMIERKLGRKTSNQLQPIRIVKPRIRNGVCCLEIEWEKPE------------ 421

  Fly   437 AEYEAE--HPKGIEELYYTIEPLDMLETAYPDLVAAF------LKSKEKPAKKTTRKKKTASEEE 493
             .|..|  .|.|::.|  |||...:.|.|||::||.:      .|.|::.:|....|.|.:...|
  Rat   422 -HYSVEDTQPGGLDLL--TIEEASLFEAAYPEVVAIYQKQQSETKGKKQKSKDIKIKPKGSHLPE 483

  Fly   494 NKE---------NEPNSK--PKRVVR---KIKAQP----EENQPLLHQF------LGRKKEGTPV 534
            :.:         .||.||  ||:..:   :|...|    |...|.|..|      ||...:...:
  Rat   484 SDDVISSQSLITLEPISKAFPKQNPKFDLEISPDPILAQESTSPSLSSFVSPENALGLNLQEQLM 548

  Fly   535 KAPAPQRQQCSTPITKFLPSDLESDCDAE-------EFDMSDIVKGIISNPNAKPALTNHDGHQL 592
            .:|.....:.:..::.||.|:......:.       :..:|.|.....|..|:.....|.....|
  Rat   549 PSPRTLAVKQTKDVSNFLVSECSQPSSSSHNISVITDLHLSTIDWAGTSFSNSPAVQRNTFSQDL 613

  Fly   593 HYEPMA-------EDLSLRLAQMSLGNVNESPKVETKRDLSQ---------------VDQLPQSK 635
            ..||.:       |.||....|.:|.|     || :.|.|.:               :..||..:
  Rat   614 QSEPESSAILPAFEQLSYESEQCTLSN-----KV-SNRGLQKSGPEEHLLSSITGLHLHDLPLKE 672

  Fly   636 RFSLEDS---FDLLVKGDLQKLARTPVERFKMQHRISEKIPTPVKPLDNISYFFNQSSDNADVF- 696
            |..::.|   :::....||:.|..|      |.|..     .........|:|   |.|...|:
  Rat   673 RIHIKSSCPQYNVGADADLESLPLT------MNHSC-----IAYSSSGGSSHF---SKDLTGVYL 723

  Fly   697 -EELMNSSLV 705
             :||.||.::
  Rat   724 QKELRNSKVL 733

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gen	NP_647943.2	PIN_GEN1	1..385	CDD:189039	138/399 (35%)
Gen	NP_647943.2	H3TH_GEN1	210..342	CDD:188625	44/142 (31%)
Gen1	XP_006239958.1	PIN_GEN1	1..193	CDD:189039	85/209 (41%)
Gen1	XP_006239958.1	H3TH_StructSpec-5'-nucleases	195..337	CDD:304556	44/142 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166338057
Domainoid	1	1.000	83	1.000	Domainoid score	I8196
eggNOG	1	0.900	-	-		E1_COG0258
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	263	1.000	Inparanoid score	I3012
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1094524at2759
OrthoFinder	1	1.000	-	-		FOG0005192
OrthoInspector	1	1.000	-	-		oto97234
orthoMCL	1	0.900	-	-		OOG6_106696
Panther	1	1.100	-	-	LDO	PTHR11081
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X4810
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	14	13.760