DRSC/TRiP Functional Genomics Resources

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Protein Alignment Gen and Exo1

DIOPT Version :10

Sequence 1:NP_647943.2 Gene:Gen / 38594 FlyBaseID:FBgn0263831 Length:726 Species:Drosophila melanogaster
Sequence 2:NP_036142.2 Gene:Exo1 / 26909 MGIID:1349427 Length:837 Species:Mus musculus


Alignment Length:811 Identity:163/811 - (20%)
Similarity:284/811 - (35%) Gaps:207/811 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MGVKELWGVLTPHCERKPINELRGKKVAIDLAGWV-------CESL---NVVDYFVHPRHHLKNL 55
            ||::.|...:....|...:.:.:|:.||:|...|:       .|.|   ...|.:|.......|:
Mouse     1 MGIQGLLQFIQEASEPVNVKKYKGQAVAVDTYCWLHKGAIACAEKLAKGEPTDRYVGFCMKFVNM 65

  Fly    56 FFRTCYLIWEQVTPVFVLEGVAPKLKSQVIAKRNELQ----------FRGVKPKNSPEC------ 104
                  |:...|.|:.:.:|.....|.:|...|.|.:          .|..|...:.:|      
Mouse    66 ------LLSYGVKPILIFDGCTLPSKKEVERSRRERRQSNLLKGKQLLREGKVSEARDCFARSIN 124

  Fly   105 -TQSQPSKGDKGRSRFNHVLKQCETLLLSMGIQCVQGPGEAEAYCAFLNKHGLVDGVISQDSDCF 168
             |.:...|          |:|....|    |:.|:..|.||:|..|:|||.|:|..||::|||..
Mouse   125 ITHAMAHK----------VIKAARAL----GVDCLVAPYEADAQLAYLNKAGIVQAVITEDSDLL 175

  Fly   169 AYGAVRV---YRNFSVSTQGAQAAAGGAVDIYDMREITSRMDFGQQKIIVMALLCGCDYCPD--G 228
            |:|..:|   ...|....:..||..|....:.|:        |.::|...|.:|.||||...  |
Mouse   176 AFGCKKVILKMDQFGNGLEVDQARLGMCKQLGDV--------FTEEKFRYMCILSGCDYLASLRG 232

  Fly   229 IGGIGKDGVLKLFNKYKETEILDRMRSW-----------------RGETDKYNALEIRVDDKSIC 276
            ||......||:|.|.....:::.::..:                 ...|..|..:...:..|.:.
Mouse   233 IGLAKACKVLRLANNPDIVKVIKKIGHYLRMNITVPEDYITGFIRANNTFLYQLVFDPIQRKLVP 297

  Fly   277 SNC-GHIGKTQSHTKSGCSVCRTHKGCDESLWKEQRLSIKSELTLRRKALLSPDFPNEEIIAEFL 340
            .|. |.....::.|.:|..|                    .:....:.||.:.|....|.|.:: 
Mouse   298 LNAYGDDVNPETLTYAGQYV--------------------GDSVALQIALGNRDVNTFEQIDDY- 341

  Fly   341 SEPDTIP--NLNLNWRQPNLVKFIKQIGHLLQWPEIYCFQKFFPILTRWQVQQSKQEKILIQPHE 403
             .|||:|  :.:.:|   |.....|..|....|.:.||     |.|....|..:.|.|  .:|..
Mouse   342 -SPDTMPAHSRSHSW---NEKAGQKPPGTNSIWHKNYC-----PRLEVNSVSHAPQLK--EKPST 395

  Fly   404 IIKKRTV--KG--VPSLELRWHDPSGIFKGLIPDKQIAEYEAEHPKGIEELYY---TIEPLDMLE 461
            :..|:.:  ||  :|........|..  :.|..|..:::|.:...| |:|...   |......:.
Mouse   396 LGLKQVISTKGLNLPRKSCVLKRPRN--EALAEDDLLSQYSSVSKK-IKENGCGDGTSPNSSKMS 457

  Fly   462 TAYPDLVAAFLKSKEKPAKKTTRKKKTASEEENKEN----EPNSKPKRVVRKIKAQPEENQPLLH 522
            .:.||...|.......|: |...|..|..:..|:|:    .|.::.:..   ..:|..:|     
Mouse   458 KSCPDSGTAHKTDAHTPS-KMRNKFATFLQRRNEESGAVVVPGTRSRFF---CSSQDFDN----- 513

  Fly   523 QFLGRKKEGTPVKAPAPQRQQCSTPITKFLPSDLESDCDAEEFDMSDIVKGIISNPNAKPALTNH 587
             |:.:|:.|.|:.......:..::                        :.|.:..|:.       
Mouse   514 -FIPKKESGQPLNETVATGKATTS------------------------LLGALDCPDT------- 546

  Fly   588 DGHQLHYEPMAEDLSLRLAQMSLGNVNESPKVETKRDLSQVDQL-----PQSKRFSLEDSFDLLV 647
            :||    :|:..:.:..|:....||...||:.|.:.  |:..:|     |.|.. :|...|..  
Mouse   547 EGH----KPVDANGTHNLSSQIPGNAAVSPEDEAQS--SETSKLLGAMSPPSLG-TLRSCFSW-- 602

  Fly   648 KGDLQKLARTP-------VERFKMQ------------------HRISEKIPTPVKPLDNISYFFN 687
            .|.|::.:|||       :::|:.:                  ...||.:....:||..:. ..:
Mouse   603 SGTLREFSRTPSPSASTTLQQFRRKSDPPACLPEASAVVTDRCDSKSEMLGETSQPLHELG-CSS 666

  Fly   688 QSSDNADVFEELMNSSLVPQDQEDNAEDEEE 718
            :|.::.|....|..|||......|:..:|.:
Mouse   667 RSQESMDSSCGLNTSSLSQPSSRDSGSEESD 697

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
GenNP_647943.2 PIN_GEN1 2..207 CDD:350217 54/234 (23%)
H3TH_GEN1 210..342 CDD:188625 27/151 (18%)
Chromo_2 400..473 CDD:465841 16/79 (20%)
Exo1NP_036142.2 PIN_EXO1 1..201 CDD:350207 53/219 (24%)
N-domain 1..99 22/103 (21%)
Interaction with MSH3. /evidence=ECO:0000250 129..386 71/308 (23%)
I-domain 138..229 34/102 (33%)
H3TH_EXO1 213..289 CDD:188628 16/75 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 345..367 6/24 (25%)
Interaction with MLH1. /evidence=ECO:0000250 387..488 22/106 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 440..477 7/37 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 555..589 8/35 (23%)
Interaction with MSH2. /evidence=ECO:0000250 591..837 21/111 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 608..740 16/91 (18%)
Interaction with MLH1. /evidence=ECO:0000250 778..837
Blue background indicates that the domain is not in the aligned region.

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