DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Gen and Exo1

DIOPT Version :9

Sequence 1:NP_647943.2 Gene:Gen / 38594 FlyBaseID:FBgn0263831 Length:726 Species:Drosophila melanogaster
Sequence 2:NP_036142.2 Gene:Exo1 / 26909 MGIID:1349427 Length:837 Species:Mus musculus


Alignment Length:811 Identity:163/811 - (20%)
Similarity:284/811 - (35%) Gaps:207/811 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MGVKELWGVLTPHCERKPINELRGKKVAIDLAGWV-------CESL---NVVDYFVHPRHHLKNL 55
            ||::.|...:....|...:.:.:|:.||:|...|:       .|.|   ...|.:|.......|:
Mouse     1 MGIQGLLQFIQEASEPVNVKKYKGQAVAVDTYCWLHKGAIACAEKLAKGEPTDRYVGFCMKFVNM 65

  Fly    56 FFRTCYLIWEQVTPVFVLEGVAPKLKSQVIAKRNELQ----------FRGVKPKNSPEC------ 104
                  |:...|.|:.:.:|.....|.:|...|.|.:          .|..|...:.:|      
Mouse    66 ------LLSYGVKPILIFDGCTLPSKKEVERSRRERRQSNLLKGKQLLREGKVSEARDCFARSIN 124

  Fly   105 -TQSQPSKGDKGRSRFNHVLKQCETLLLSMGIQCVQGPGEAEAYCAFLNKHGLVDGVISQDSDCF 168
             |.:...|          |:|....|    |:.|:..|.||:|..|:|||.|:|..||::|||..
Mouse   125 ITHAMAHK----------VIKAARAL----GVDCLVAPYEADAQLAYLNKAGIVQAVITEDSDLL 175

  Fly   169 AYGAVRV---YRNFSVSTQGAQAAAGGAVDIYDMREITSRMDFGQQKIIVMALLCGCDYCPD--G 228
            |:|..:|   ...|....:..||..|....:.|:        |.::|...|.:|.||||...  |
Mouse   176 AFGCKKVILKMDQFGNGLEVDQARLGMCKQLGDV--------FTEEKFRYMCILSGCDYLASLRG 232

  Fly   229 IGGIGKDGVLKLFNKYKETEILDRMRSW-----------------RGETDKYNALEIRVDDKSIC 276
            ||......||:|.|.....:::.::..:                 ...|..|..:...:..|.:.
Mouse   233 IGLAKACKVLRLANNPDIVKVIKKIGHYLRMNITVPEDYITGFIRANNTFLYQLVFDPIQRKLVP 297

  Fly   277 SNC-GHIGKTQSHTKSGCSVCRTHKGCDESLWKEQRLSIKSELTLRRKALLSPDFPNEEIIAEFL 340
            .|. |.....::.|.:|..|                    .:....:.||.:.|....|.|.:: 
Mouse   298 LNAYGDDVNPETLTYAGQYV--------------------GDSVALQIALGNRDVNTFEQIDDY- 341

  Fly   341 SEPDTIP--NLNLNWRQPNLVKFIKQIGHLLQWPEIYCFQKFFPILTRWQVQQSKQEKILIQPHE 403
             .|||:|  :.:.:|   |.....|..|....|.:.||     |.|....|..:.|.|  .:|..
Mouse   342 -SPDTMPAHSRSHSW---NEKAGQKPPGTNSIWHKNYC-----PRLEVNSVSHAPQLK--EKPST 395

  Fly   404 IIKKRTV--KG--VPSLELRWHDPSGIFKGLIPDKQIAEYEAEHPKGIEELYY---TIEPLDMLE 461
            :..|:.:  ||  :|........|..  :.|..|..:::|.:...| |:|...   |......:.
Mouse   396 LGLKQVISTKGLNLPRKSCVLKRPRN--EALAEDDLLSQYSSVSKK-IKENGCGDGTSPNSSKMS 457

  Fly   462 TAYPDLVAAFLKSKEKPAKKTTRKKKTASEEENKEN----EPNSKPKRVVRKIKAQPEENQPLLH 522
            .:.||...|.......|: |...|..|..:..|:|:    .|.::.:..   ..:|..:|     
Mouse   458 KSCPDSGTAHKTDAHTPS-KMRNKFATFLQRRNEESGAVVVPGTRSRFF---CSSQDFDN----- 513

  Fly   523 QFLGRKKEGTPVKAPAPQRQQCSTPITKFLPSDLESDCDAEEFDMSDIVKGIISNPNAKPALTNH 587
             |:.:|:.|.|:.......:..::                        :.|.:..|:.       
Mouse   514 -FIPKKESGQPLNETVATGKATTS------------------------LLGALDCPDT------- 546

  Fly   588 DGHQLHYEPMAEDLSLRLAQMSLGNVNESPKVETKRDLSQVDQL-----PQSKRFSLEDSFDLLV 647
            :||    :|:..:.:..|:....||...||:.|.:.  |:..:|     |.|.. :|...|..  
Mouse   547 EGH----KPVDANGTHNLSSQIPGNAAVSPEDEAQS--SETSKLLGAMSPPSLG-TLRSCFSW-- 602

  Fly   648 KGDLQKLARTP-------VERFKMQ------------------HRISEKIPTPVKPLDNISYFFN 687
            .|.|::.:|||       :::|:.:                  ...||.:....:||..:. ..:
Mouse   603 SGTLREFSRTPSPSASTTLQQFRRKSDPPACLPEASAVVTDRCDSKSEMLGETSQPLHELG-CSS 666

  Fly   688 QSSDNADVFEELMNSSLVPQDQEDNAEDEEE 718
            :|.::.|....|..|||......|:..:|.:
Mouse   667 RSQESMDSSCGLNTSSLSQPSSRDSGSEESD 697

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
GenNP_647943.2 PIN_GEN1 1..385 CDD:189039 95/435 (22%)
H3TH_GEN1 210..342 CDD:188625 27/151 (18%)
Exo1NP_036142.2 PIN_EXO1 1..201 CDD:350207 53/219 (24%)
N-domain 1..99 22/103 (21%)
Interaction with MSH3. /evidence=ECO:0000250 129..386 71/308 (23%)
I-domain 138..229 34/102 (33%)
H3TH_EXO1 213..289 CDD:188628 16/75 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 345..367 6/24 (25%)
Interaction with MLH1. /evidence=ECO:0000250 387..488 22/106 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 440..477 7/37 (19%)
AF-4 555..>765 CDD:368289 30/149 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 555..589 8/35 (23%)
Interaction with MSH2. /evidence=ECO:0000250 591..837 21/111 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 608..740 16/91 (18%)
Interaction with MLH1. /evidence=ECO:0000250 778..837
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG0258
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
32.810

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