Protein Alignment Gen and FEN1

DIOPT Version :9

• Sequence 1: NP_647943.2
• Gene: Gen / 38594
• FlyBaseID: FBgn0263831
• Length: 726
• Species: Drosophila melanogaster
• Sequence 2: NP_004102.1
• Gene: FEN1 / 2237
• HGNCID: 3650
• Length: 380
• Species: Homo sapiens
• Alignment Length: 522
• Identity: 115/522 - (22%)
• Similarity: 195/522 - (37%)
• Gaps: 171/522 - (32%)

  Fly     2 GVKELWGVLTPHCERKPINELR---GKKVAIDLAGWVCESLNVVDYFVHPRH------------- 50
            |:.:|...:.|...|:  |:::   |:|||||      .|:::..:.:..|.
Human     5 GLAKLIADVAPSAIRE--NDIKSYFGRKVAID------ASMSIYQFLIAVRQGGDVLQNEEGETT 61

  Fly    51 -HLKNLFFRTCYLIWEQVTPVFVLEGVAPKLKSQVIAKRNELQFRGVKPKNSPECTQSQPSKGDK 114
             ||..:|:||..::...:.||:|.:|..|:|||..:|||:|.:....|.....:...:: .:.:|
Human    62 SHLMGMFYRTIRMMENGIKPVYVFDGKPPQLKSGELAKRSERRAEAEKQLQQAQAAGAE-QEVEK 125

  Fly   115 GRSRFNHVLKQ----CETLLLSMGIQCVQGPGEAEAYCAFLNKHGLVDGVISQDSDCFAYGAVRV 175
            ...|...|.||    |:.||..|||..:..|.||||.||.|.|.|.|....::|.||..:|:..:
Human   126 FTKRLVKVTKQHNDECKHLLSLMGIPYLDAPSEAEASCAALVKAGKVYAAATEDMDCLTFGSPVL 190

  Fly   176 YRNFSVSTQGAQAAAGGAVDIYDMREITSRMDFGQQKIIVMALLCGCDYCPDGIGGIGKDGVLKL 240
            .|:.:     |..|....:..:.:..|...:...|::.:.:.:|.|.||| :.|.|||....:.|
Human   191 MRHLT-----ASEAKKLPIQEFHLSRILQELGLNQEQFVDLCILLGSDYC-ESIRGIGPKRAVDL 249

  Fly   241 FNKYKETEILDRMRSWRGETDKYNALEIRVDDKSICSNCGHIGKTQSHTKSGCSVCRTHKGCDES 305
            ..|:|..|.:.|    |.:.:||...|          |..|   .::|
Human   250 IQKHKSIEEIVR----RLDPNKYPVPE----------NWLH---KEAH----------------- 280

  Fly   306 LWKEQRLSIKSELTLRRKALLSPDFPNEEIIAEFLSEPDTIPNLNLNWRQPN---LVKFIKQIGH 367
                             :..|.|:          :.:|:::   .|.|.:||   |:||:
Human   281 -----------------QLFLEPE----------VLDPESV---ELKWSEPNEEELIKFM----- 310

  Fly   368 LLQWPEIYCFQKFFPILTRWQVQQSKQEKILIQPHEIIKKRTVKGVPSLELRWHDPSGIFKGLIP 432
                    |.:|           |..:|:|......:.|.|               .|..:|.:.
Human   311 --------CGEK-----------QFSEERIRSGVKRLSKSR---------------QGSTQGRLD 341

  Fly   433 DKQIAEYEAEHPKGIEELYYTIEPLDMLETAYPDLVAAFLKSKEKPAKKTTRKK-KTASEEENKE 496
            |                 ::.:  ...|.:|         |.||...|.:|:|| ||.:..:.|.
Human   342 D-----------------FFKV--TGSLSSA---------KRKEPEPKGSTKKKAKTGAAGKFKR 378

  Fly   497 NE 498
            .:
Human   379 GK 380

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Gen	NP_647943.2	PIN_GEN1	1..385	CDD:189039	95/406 (23%)
		H3TH_GEN1	210..342	CDD:188625	24/131 (18%)
FEN1	NP_004102.1	PTZ00217	1..373	CDD:240317	114/513 (22%)
		N-domain	1..104		30/106 (28%)
		I-domain	122..253		41/136 (30%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	327..380		17/95 (18%)
		Interaction with PCNA. /evidence=ECO:0000269|PubMed:9305916	336..344		2/24 (8%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0258
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1094524at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820