DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Gen and Gen1

DIOPT Version :9

Sequence 1:	NP_647943.2	Gene:	Gen / 38594	FlyBaseID:	FBgn0263831	Length:	726	Species:	Drosophila melanogaster
Sequence 2:	NP_796305.3	Gene:	Gen1 / 209334	MGIID:	2443149	Length:	908	Species:	Mus musculus

Alignment Length:	805	Identity:	231/805 - (28%)
Similarity:	359/805 - (44%)	Gaps:	160/805 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MGVKELWGVLTPHCERKPINELRGKKVAIDLAGWVCESLNVVDYF-VHPRHHLKNLFFRTCYLIW 64
            |||.:||.:|.|..:...:.:|.||.:|:||:.||||:..|.... ...:.||:|||||..||..
Mouse     1 MGVNDLWQILEPVKQHIHLQDLSGKTIAVDLSLWVCEAQTVKKMIGTVKKPHLRNLFFRISYLTQ 65

  Fly    65 EQVTPVFVLEGVAPKLKSQVIAKRNELQFRGVKPKNSPECTQSQPSKGDKGRSRFNHVLKQCETL 129
            ..|..|||:||..|.||:.||:||.:.:: |...|:..:.|         |||.|..||::|..:
Mouse    66 MNVKLVFVMEGEPPMLKADVISKRTQTRY-GPSGKSRSQKT---------GRSHFKSVLRECLEM 120

  Fly   130 LLSMGIQCVQGPGEAEAYCAFLNKHGLVDGVISQDSDCFAYGAVRVYRNFSVSTQGAQAAAGGAV 194
            |..:|:..||..|||||.||:||..|.|||.::.|.|.|.|||..|||||:::|:...      |
Mouse   121 LECLGMPWVQAAGEAEAMCAYLNASGHVDGCLTNDGDAFLYGAQTVYRNFTMNTKDPH------V 179

  Fly   195 DIYDMREITSRMDFGQQKIIVMALLCGCDYCPDGIGGIGKDGVLKLFNKYKETEILDRMRSWRGE 259
            |.|.:..|.|::...:..::.:|:|.||||.|.|:.|:||:..|||...:|...:|.|...|. |
Mouse   180 DCYTISSIKSKLGLDRDALVGLAVLLGCDYLPKGVPGVGKEQALKLLQIFKGQSLLQRFNQWI-E 243

  Fly   260 TDKYNALEIRVDDKSICSNCGHIGKTQSHTKSGCSVCRTHKGCD--------ESLWKE----QRL 312
            ...|:..:........||.|.|.|..:.|.::||.:|::.|.|:        ...|.:    :.|
Mouse   244 DPCYSVPQSAPKKVVHCSVCSHPGSPKDHERNGCILCKSDKYCEPHDYDYLCPCEWHQTDHNRHL 308

  Fly   313 SIKSELTLRRKALLSPDFPNEEIIAEFLSEPDTIPNLNLN-------WRQPNLVKFIKQIGHLLQ 370
            | :.|..:::||.....||..|:|.|||        ||.|       :::|:|:.|.:.....::
Mouse   309 S-EIENNIKKKACSCEGFPFHEVIQEFL--------LNKNKMLKPITYQRPDLLLFQRFTVQKME 364

  Fly   371 WPEIYCFQKFFPILTRWQVQQSKQEKIL---IQPHEIIKKRTVKGVPSLELRWHDPSGIFKGLIP 432
            ||..|..:|...:|||:.:.:.|..:..   :||..|:|.|...||..||:.|..|.
Mouse   365 WPSHYACEKLLVLLTRYDMIERKHGRKTSNQLQPIRIVKPRVRNGVHCLEIEWEKPE-------- 421

  Fly   433 DKQIAEYEAEHPKGIEELYYTIEPLDMLETAYPDLVAAFLK--SKEKPAKKTTRKKK-------T 488
                 .|..|.....:....|:|...:.|.||||.||.:.|  |:.|..|:.:.|.|       .
Mouse   422 -----HYVVEDGDPGKLSLLTMEEASLFEAAYPDAVAVYQKQLSETKGRKQKSMKNKPKGSHLPE 481

  Fly   489 ASEEENKEN----EPNSK--PKRVVR--------KIKAQPEENQPLLHQFLGRKKEGTPVKAPAP 539
            |.:..|.::    :|.||  ||:..:        .|.|| |...|.|:.|:      :|..||..
Mouse   482 ADDVINSQSLMTLKPTSKAFPKQNPKINLENSPDPILAQ-ESTSPSLNSFV------SPENAPCL 539

  Fly   540 QRQQCSTPITKFLPSDLESDCDAEEFDMSDIVKGIISNPNAKPALTNHDGHQLHYEPMAEDLSLR 604
            ..|:...|..:.|.  ::...|...|.:|:.         ::|:.::||      ..:..||.|.
Mouse   540 NLQEQLVPSPRTLA--IKQSKDVSHFLVSEC---------SQPSSSSHD------ISVITDLQLS 587

  Fly   605 LAQMSLGNVNESPKVET---KRDLSQVDQ----LPQSKRFSLE------DS----FDL------- 645
            ....:..:.:.||.|:.   .:||:...:    ||..::.|.|      ||    .||
Mouse   588 TIDWAGTSFSNSPAVQRNTFSQDLASESESSAILPDFEQLSYESEQGTSDSEGSGRDLQQSNPEE 652

  Fly   646 -LVKG-------DLQKLARTPVERFKMQHRIS-----EKIPTPVKPLDNISYFFNQSSDNADVF- 696
             |:.|       ||....|..::....|:.:.     |.:|..:|. ..|:|   .|||.:..|
Mouse   653 QLLSGISALHLHDLPLKERIRIKSSCPQYNVGADAGLESLPLKLKG-SCIAY---SSSDGSSNFS 713

  Fly   697 ---------EELMNSSLVPQDQEDN 712
                     :|..||.::....::|
Mouse   714 KDLTGVYLHKESRNSKVLDSRLQEN 738

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gen	NP_647943.2	PIN_GEN1	1..385	CDD:189039	138/403 (34%)
Gen	NP_647943.2	H3TH_GEN1	210..342	CDD:188625	44/143 (31%)
Gen1	NP_796305.3	PIN_GEN1	2..206	CDD:350217	85/219 (39%)
		XPG-N domain. /evidence=ECO:0000250\|UniProtKB:Q17RS7	2..96		39/94 (41%)
		XPG-I domain. /evidence=ECO:0000250\|UniProtKB:Q17RS7	122..208		36/91 (40%)
		H3TH_StructSpec-5'-nucleases	195..337	CDD:389913	44/151 (29%)
		5'-3' exonuclease domain. /evidence=ECO:0000250\|UniProtKB:Q17RS7	208..383		53/184 (29%)
		Chromodomain. /evidence=ECO:0000250\|UniProtKB:Q17RS7	389..463		24/86 (28%)
		Chromo_2	397..457	CDD:376128	22/72 (31%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	460..482		5/21 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	629..650		5/20 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	792..834
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	853..886
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167834477
Domainoid	1	1.000	80	1.000	Domainoid score	I8628
eggNOG	1	0.900	-	-		E1_COG0258
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	259	1.000	Inparanoid score	I3110
Isobase	1	0.950	-	0	Normalized mean entropy	S5877
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1094524at2759
OrthoFinder	1	1.000	-	-		FOG0005192
OrthoInspector	1	1.000	-	-		oto93692
orthoMCL	1	0.900	-	-		OOG6_106696
Panther	1	1.100	-	-	LDO	PTHR11081
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R11167
SonicParanoid	1	1.000	-	-		X4810
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	16	15.740