Protein Alignment Gen and ERCC5

DIOPT Version :10

• Sequence 1: NP_647943.2
• Gene: Gen / 38594
• FlyBaseID: FBgn0263831
• Length: 726
• Species: Drosophila melanogaster
• Sequence 2: NP_000114.3
• Gene: ERCC5 / 2073
• HGNCID: 3437
• Length: 1186
• Species: Homo sapiens
• Alignment Length: 455
• Identity: 96/455 - (21%)
• Similarity: 167/455 - (36%)
• Gaps: 124/455 - (27%)

  Fly    64 WEQVTPVFVLEGVAPKLKSQVIAKRNELQFRGVKPKNSPECTQSQPSKGDKGRSRFNHVLKQCET 128
            |:.:.    ||.: ..|:|.::|::|.|:.:..:.:........|             :..:.:.
Human   728 WQDIN----LEEL-ETLESNLLAQQNSLKAQKQQQERIAATVTGQ-------------MFLESQE 774

  Fly   129 LLLSMGIQCVQGPGEAEAYCAFLNKHGLVDGVISQDSDCFAYGAVRVYRNFSVSTQGAQAAAGGA 193
            ||...||..:|.|.||||.||.|:......|.|:.|||.:.:||..|||||....:        .
Human   775 LLRLFGIPYIQAPMEAEAQCAILDLTDQTSGTITDDSDIWLFGARHVYRNFFNKNK--------F 831

  Fly   194 VDIYDMREITSRMDFGQQKIIVMALLCGCDYCPDGIGGIGKDGVLKLFNKY--KETEILDRMRSW 256
            |:.|...:..:::...:.|:|.:|.|.|.|| .:||..:|....:::.|::  ...|.|.:...|
Human   832 VEYYQYVDFHNQLGLDRNKLINLAYLLGSDY-TEGIPTVGCVTAMEILNEFPGHGLEPLLKFSEW 895

  Fly   257 RGETDKYNALEIRVDDKSICSNCGHIGKTQSHTKSGCSVCRTHKGCDESLWKEQRLSIKSELTLR 321
            ..|..|...:.....|                ||                       :|.:|
Human   896 WHEAQKNPKIRPNPHD----------------TK-----------------------VKKKL--- 918

  Fly   322 RKALLSPDFPNEEIIAEFLSEPDTIPNLNLNWRQPNLVKFIKQIGHLLQWPEIYCFQKFFPILTR 386
            |...|:|.|||..:...:|.........:..|.:|:|.|..:.......|......:..||:|.:
Human   919 RTLQLTPGFPNPAVAEAYLKPVVDDSKGSFLWGKPDLDKIREFCQRYFGWNRTKTDESLFPVLKQ 983

  Fly   387 WQVQQ-----------SKQEKILIQPHEIIKKRTVKGVPSLELRWHDPSGIFKGLIPDKQIAEYE 440
            ...||           ::|||   :..:.||.:.:....:..||            .:|:.|..|
Human   984 LDAQQTQLRIDSFFRLAQQEK---EDAKRIKSQRLNRAVTCMLR------------KEKEAAASE 1033

  Fly   441 AEHPKGIEELYYTIE-PLDMLETAYPDLVAAFLKSKEKPAKK---------TTRKKKTASEEENK 495
                  ||.:...:| ..::|:           |:|.|..|:         ::.|:|..|:.:.|
Human  1034 ------IEAVSVAMEKEFELLD-----------KAKGKTQKRGITNTLEESSSLKRKRLSDSKGK 1081

  Fly   496  495
            Human  1082  1081

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Gen	NP_647943.2	PIN_GEN1	2..207	CDD:350217	36/142 (25%)
		H3TH_GEN1	210..342	CDD:188625	28/133 (21%)
		Chromo_2	400..473	CDD:465841	11/73 (15%)
ERCC5	NP_000114.3	rad2	1..1029	CDD:273166	82/384 (21%)
		N-domain. /evidence=ECO:0000305|PubMed:32522879	1..78
		DNA-binding, may bind to the undamaged single-strand DNA of the DNA repair bubble. /evidence=ECO:0000269|PubMed:32821917, ECO:0000312|PDB:6TUW, ECO:0007744|PDB:6TUX	31..67
		Spacer region. /evidence=ECO:0000269|PubMed:16246722	79..785		13/74 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	306..342
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	354..385
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	404..473
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	510..533
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	667..724
		I-domain. /evidence=ECO:0000305|PubMed:32522879	786..881		33/103 (32%)
		DNA-binding, may bind to the undamaged single-strand DNA of the DNA repair bubble. /evidence=ECO:0000269|PubMed:32821917, ECO:0000312|PDB:6TUW, ECO:0007744|PDB:6TUX	820..836		6/23 (26%)
		DNA-binding, H2TH (helix-2turn-helix) motif which binds double-stranded DNA. /evidence=ECO:0000269|PubMed:32821917, ECO:0000312|PDB:6TUW, ECO:0007744|PDB:6TUX	848..880		10/32 (31%)
		DNA-binding, may bind double-stranded DNA. /evidence=ECO:0000269|PubMed:32821917, ECO:0000312|PDB:6TUW, ECO:0007744|PDB:6TUX	912..918		3/28 (11%)
		Interaction with PCNA. /evidence=ECO:0000269|PubMed:9305916	981..1009		6/30 (20%)
		Interaction with ERCC6/CSB. /evidence=ECO:0000269|PubMed:16246722	1011..1186		18/100 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1056..1081		4/24 (17%)
		Nuclear localization signal 1. /evidence=ECO:0000305|PubMed:26812207	1057..1074		2/16 (13%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1095..1186
		Nuclear localization signal 2. /evidence=ECO:0000305|PubMed:26812207	1169..1186