Protein Alignment Gen and exo-1

DIOPT Version :10

• Sequence 1: NP_647943.2
• Gene: Gen / 38594
• FlyBaseID: FBgn0263831
• Length: 726
• Species: Drosophila melanogaster
• Sequence 2: NP_499770.1
• Gene: exo-1 / 176765
• WormBaseID: WBGene00009731
• Length: 639
• Species: Caenorhabditis elegans
• Alignment Length: 656
• Identity: 140/656 - (21%)
• Similarity: 232/656 - (35%)
• Gaps: 188/656 - (28%)

  Fly     1 MGVKELWGVLTPHCERKPINELRGKKVAIDLAGWVC-----------------ESLNVVDYFVHP 48
            ||:..|...:...|.:..|.|||||.||||::   |                 |:.:.|:|.
 Worm     1 MGISGLLPFVKNACRKGNILELRGKSVAIDVS---CLLHRGLTGCMDKIHMGEETQSYVNYV--- 59

  Fly    49 RHHLKNLFFRTCYLIWEQVTPVFVLEGVAPKLKSQVIAKRNELQFRGVKPKNSPECTQSQPSKGD 113
            ..::|.|....|::       |.|.:|.....|.....:|.||:      :...|..:...:||.
 Worm    60 NKYVKELLGMGCHV-------VMVFDGRPLPAKKGTNEERRELR------EKRKEHAEMLLAKGL 111

  Fly   114 KGRSRFNH---------VLKQCETLLLSM-GIQCVQGPGEAEAYCAFLNKHGLVDGVISQDSDCF 168
            :..:|..:         :::.......|| .:..|..|.||:|..|:|.:..|||.||::|||..
 Worm   112 EREARDTYRLATSISADIVENTIQYFRSMTNVDIVVAPYEADAQLAYLVQEKLVDAVITEDSDLI 176

  Fly   169 AYGAVRVYRNFSVSTQGAQAAAGGAVDIYDMREITS---------RMDFGQQKIIVMALLCGCDY 224
            .:|...:|..:..:|        |...:|:...:.:         :.||  .|...:.:|.||||
 Worm   177 VFGCEMIYFKWQSAT--------GECSVYEKCNLKNCFTGELGGDKFDF--VKFRRICILSGCDY 231

  Fly   225 CPDGIGGIGKDGVLKLF----------------------------------------NKYKETEI 249
            ...|:.|:|.....|.|                                        |.:|...:
 Worm   232 LQAGLPGVGLSTAAKFFSMTSIKDLRTLLRKVPSYLKNPKLKEHVNDEFIRNFEKAENTFKHQIV 296

  Fly   250 LDRMRSWRGETDKY--NALEIRVDDKSICSNCGHIGKTQSHTKSGCSVCRTHKGCDESLWKEQRL 312
            .|.....:.....|  ..|...|||.....:.....||...:||     ..:.|...:    ||:
 Worm   297 FDPRERCQKPLTPYPKEVLMTGVDDLEEVIDLDSPKKTAPSSKS-----FAYAGTAST----QRI 352

  Fly   313 SIKSELTLRRKALLSPDFPNEEIIAE--FLSEPD---TIPNLNLNWRQPNLVKFIKQIGHLLQWP 372
            :|       |.||.:|:  |:..|.:  .|.:|.   ::..|....:...|.|..||    .:..
 Worm   353 AI-------RLALGNPE--NKSSIDDQFLLVQPTPEWSVWGLRYESKGSTLDKISKQ----KELE 404

  Fly   373 EIYC---FQKFFPILTRWQV-----QQSKQEKILIQ-------PHEIIKKRTVKGVPSLELRWHD 422
            ...|   |:...|.:.|.:|     ....::.|:.|       ..:.||||  |..|.::..
 Worm   405 ATQCGGAFKLDSPSVKRVKVASKTTPNDDEDDIVKQFMADIEKEKKAIKKR--KNAPQVDYN--- 464

  Fly   423 PSGIFKGLIPDKQIAEYEAEHPKGIEELYYTIEPLDMLETAYPDLVAAFLKSKEKPAKKTTRKKK 487
                     .|..:.:| ||.|.  |:....:|.:|       |..:.|.:.|   .|:.|  |:
 Worm   465 ---------ADVLLKKY-AEPPP--EKRQKILEVID-------DDFSEFFQEK---VKENT--KE 505

  Fly   488 TASEEENKENEPNSKPKRVVRKIKAQPEE-------NQPLL-HQFLGRKKEGTPVKAPAPQRQQC 544
            :.:||:.:.:....||..::||..:.|:.       ..||| ||  .......|.:.||...:..
 Worm   506 SVAEEKVENSNEELKPPPILRKAVSTPDSARKTHKFQSPLLNHQ--NSAPPSLPDRKPAQTSKYF 568

  Fly   545 STPITK 550
            |.|.::
 Worm   569 SKPTSE 574

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Gen	NP_647943.2	PIN_GEN1	2..207	CDD:350217	53/240 (22%)
		H3TH_GEN1	210..342	CDD:188625	34/175 (19%)
		Chromo_2	400..473	CDD:465841	17/79 (22%)
exo-1	NP_499770.1	PIN_EXO1	1..204	CDD:350207	54/229 (24%)
		H3TH_EXO1	219..298	CDD:188628	13/78 (17%)
		PRK11198	<345..>400	CDD:236880	15/67 (22%)
		PspC_subgroup_1	<497..>598	CDD:468201	21/85 (25%)