DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Gen and Fen1

DIOPT Version :9

Sequence 1:	NP_647943.2	Gene:	Gen / 38594	FlyBaseID:	FBgn0263831	Length:	726	Species:	Drosophila melanogaster
Sequence 2:	NP_001258543.1	Gene:	Fen1 / 14156	MGIID:	102779	Length:	380	Species:	Mus musculus

Alignment Length:	389	Identity:	96/389 - (24%)
Similarity:	160/389 - (41%)	Gaps:	111/389 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 GVKELWGVLTPHCERKPINELR---GKKVAIDLAGWVCESLNVVDYFVHPRH------------- 50
            |:.:|...:.|...|:  |:::   |:|||||      .|:::..:.:..|.
Mouse     5 GLAKLIADVAPSAIRE--NDIKSYFGRKVAID------ASMSIYQFLIAVRQGGDVLQNEEGETT 61

  Fly    51 -HLKNLFFRTCYLIWEQVTPVFVLEGVAPKLKSQVIAKRNELQFRGVKPKNSPECTQSQPS---- 110
             ||..:|:||..::...:.||:|.:|..|:|||..:|||:|.:....|     :..|:|.:
Mouse    62 SHLMGMFYRTIRMMENGIKPVYVFDGKPPQLKSGELAKRSERRAEAEK-----QLQQAQEAGMEE 121

  Fly   111 KGDKGRSRFNHVLKQ----CETLLLSMGIQCVQGPGEAEAYCAFLNKHGLVDGVISQDSDCFAYG 171
            :.:|...|...|.||    |:.||..|||..:..|.||||.||.|.|.|.|....::|.||..:|
Mouse   122 EVEKFTKRLVKVTKQHNDECKHLLSLMGIPYLDAPSEAEASCAALAKAGKVYAAATEDMDCLTFG 186

  Fly   172 AVRVYRNFSVSTQGAQAAAGGAVDIYDMREITSRMDFGQQKIIVMALLCGCDYCPDGIGGIGKDG 236
            :..:.|:.:     |..|....:..:.:..:...:...|::.:.:.:|.|.||| :.|.|||...
Mouse   187 SPVLMRHLT-----ASEAKKLPIQEFHLSRVLQELGLNQEQFVDLCILLGSDYC-ESIRGIGPKR 245

  Fly   237 VLKLFNKYKETEILDRMRSWRGETDKYNALEIRVDDKSICSNCGHIGKTQSHTKSGCSVCRTHKG 301
            .:.|..|:|..|.:.|    |.:..||...|..:                            ||
Mouse   246 AVDLIQKHKSIEEIVR----RLDPSKYPVPENWL----------------------------HK- 277

  Fly   302 CDESLWKEQRLSIKSELTLRRKALLSPDFPNEEIIAEFLSEPDTIPNLNLNWRQPN---LVKFI 362
                  :.|:|.::.|       :|.|:                  ::.|.|.:||   ||||:
Mouse   278 ------EAQQLFLEPE-------VLDPE------------------SVELKWSEPNEEELVKFM 310

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gen	NP_647943.2	PIN_GEN1	1..385	CDD:189039	96/389 (25%)
Gen	NP_647943.2	H3TH_GEN1	210..342	CDD:188625	26/131 (20%)
Fen1	NP_001258543.1	PTZ00217	1..359	CDD:240317	96/389 (25%)
		I-domain	122..253		40/136 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	327..380
		Interaction with PCNA. /evidence=ECO:0000255\|HAMAP-Rule:MF_03140	336..344
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1094524at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920