DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Gen and gen1

DIOPT Version :9

Sequence 1:	NP_647943.2	Gene:	Gen / 38594	FlyBaseID:	FBgn0263831	Length:	726	Species:	Drosophila melanogaster
Sequence 2:	XP_009298211.1	Gene:	gen1 / 101884233	-ID:	-	Length:	967	Species:	Danio rerio

Alignment Length:	802	Identity:	222/802 - (27%)
Similarity:	349/802 - (43%)	Gaps:	172/802 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MGVKELWGVLTPHCERKPINELRGKKVAIDLAGWVCESLNVVDYFVH-PRHHLKNLFFRTCYLIW 64
            |||.|||.:|.|..:...:..|.||.:|:||:.||||:.:|...... .:.||:|||||...|..
Zfish     1 MGVTELWSILEPVRQSVSLYSLSGKTLAVDLSLWVCEAQHVQGMMGRVTKPHLRNLFFRVSSLTL 65

  Fly    65 EQVTPVFVLEGVAPKLKSQVIAKRNELQFRGVKPKNSPECTQSQPSKGDKGRSRFNHVLKQCETL 129
            ..|..|||:||.|||:|::.::||.|::|.|.|.|:.|     :|.| :..|.|||.||::|..:
Zfish    66 MGVKLVFVMEGEAPKIKAETMSKRTEMRFGGTKAKSIP-----KPVK-NTNRGRFNAVLRECAQM 124

  Fly   130 LLSMGIQCVQGPGEAEAYCAFLNKHGLVDGVISQDSDCFAYGAVRVYRNFSVSTQGAQAAAGGAV 194
            |..:|:..|...|||||.||||:..|||||.|:.|.|.|.|||..|||||:::|:..|      |
Zfish   125 LDCLGVPWVTAAGEAEAMCAFLDSQGLVDGCITNDGDAFLYGARTVYRNFNMTTKDPQ------V 183

  Fly   195 DIYDMREITSRMDFGQQKIIVMALLCGCDYCPDGIGGIGKDGVLKLFNKYKETEILDRMRSW--- 256
            |.|....:...:...::.::.:|:|.||||.|.||.|:|::..|||.:..:...:|.:...|
Zfish   184 DCYQSSRVQEELGLCRETLVGLAVLLGCDYIPKGIAGVGREQTLKLIHSLRGQTLLQKFSEWSSG 248

  Fly   257 -RGETDKYNALEIRVDDKSICSNCGHIGKTQSHTKSGCSVCRTHKGCDESLWKEQ---------- 310
             .|::      |:::...:.|..|.|.|..::|.:|||..|.:.:.|....:..|
Zfish   249 ASGDS------ELQMKKVTHCLVCRHPGSAKAHERSGCVFCVSERFCSPQDYDSQCPCEWHQTQA 307

  Fly   311 -RLSIKSELTLRRKALLSPDFPNEEIIAEFLSEPDTIPNLNLNWRQPNLVKFIKQIGHLLQWPEI 374
             |.:...|..:|::.|.|..||...||.|||...|. |......|:|||:...:.....:.||:.
Zfish   308 LRQASSLENNIRKRTLASEHFPFTHIINEFLLTKDK-PVQAFRRRKPNLLLMQEFALEKMDWPKH 371

  Fly   375 YCFQKFFPILTRWQV---QQSKQEKILIQPHEIIKKRTVKGVPSLELRWHDPSGIFKGLIPDKQI 436
            |..:|...::|..::   :..:.....:||..|.|.|...||..||:.|..|
Zfish   372 YSSEKLLTLMTYTEMVNRRLGRDSHTHMQPIRIYKARVRNGVSCLEVIWKTP------------- 423

  Fly   437 AEYEAEH---PKGIEEL--YYTIEPLDMLETAYPDLVAAFLKSKEKPAKKTTRKKKTASEEEN-- 494
                 ||   .:|.||.  ..|:|...:...|:|.::..|.:.:.:..:|.|:|||...::|.
Zfish   424 -----EHYVFVEGCEEQAEVRTVEEEALFSLAFPKILQEFQRERNQAQEKKTKKKKPKVKKETLA 483

  Fly   495 ----------KENEPNSKPKRVVRKIKAQPEENQPLLHQFLGRKKEGTPVKAPAPQRQQCSTPIT 549
                      .:...|:.| :||...:..|   ||.|..:.|.:.: ||   |:......|..|.
Zfish   484 DSHDAVSDLFSQMTLNTDP-QVVSSAQNPP---QPDLPPYPGIQVQ-TP---PSGNSHSVSALIG 540

  Fly   550 KFLPSDL----------------ESDCDAEEFDMSDIVKGIISN--------------PNAKPAL 584
            :...|.:                |:|....|.|...:.:.||:|              .:.:||.
Zfish   541 QLHLSSIDWDSASFTASPSQNTHETDLRPAENDNCSLKERIITNKQQAKDSDGIADGKTDLRPAE 605

  Fly   585 TN-----------------HDGHQLHYEPMAED-LSLRLAQMSLGNVNES---PKVETKRDLSQV 628
            .|                 .||       :|:| ..||.||.||.::.|.   .|.:||...|:|
Zfish   606 NNICSLKERIVAQKQRSKDSDG-------IADDKTDLRPAQHSLCSLKEQMIMKKQQTKHPGSRV 663

  Fly   629 D----------QLPQSKRFSLEDSFDLLVKG--DLQ---------------KLARTPVERFKMQH 666
            |          .:..||..::.:.||....|  ||:               |..:|....:|..:
Zfish   664 DDKADLRPAEKNVSSSKEQTIMNDFDRKTDGKTDLRPAQHSLCSLKEQIIMKKQQTKNPEYKADN 728

  Fly   667 RISEKIPTPVKPLDNISYFFNQ 688
            :      |.::|.::::....|
Zfish   729 K------TDLRPAESLTCSLKQ 744

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gen	NP_647943.2	PIN_GEN1	1..385	CDD:189039	139/399 (35%)
Gen	NP_647943.2	H3TH_GEN1	210..342	CDD:188625	41/146 (28%)
gen1	XP_009298211.1	PIN_SF	1..197	CDD:326356	88/207 (43%)
gen1	XP_009298211.1	H3TH_StructSpec-5'-nucleases	199..340	CDD:328895	41/146 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	77	1.000	Domainoid score	I8853
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1094524at2759
OrthoFinder	1	1.000	-	-		FOG0005192
OrthoInspector	1	1.000	-	-		oto41433
orthoMCL	1	0.900	-	-		OOG6_106696
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X4810
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	7	6.820