DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Srp54k and srp54

DIOPT Version :9

Sequence 1:	NP_523931.1	Gene:	Srp54k / 38593	FlyBaseID:	FBgn0010747	Length:	508	Species:	Drosophila melanogaster
Sequence 2:	NP_957282.1	Gene:	srp54 / 393963	ZFINID:	ZDB-GENE-040426-818	Length:	504	Species:	Danio rerio

Alignment Length:	505	Identity:	396/505 - (78%)
Similarity:	457/505 - (90%)	Gaps:	4/505 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MVLADLGRKITTALHSLSKATVINEEALNSMLKEICAALLEADVNIRLVKQLRENVRAVIDFDEM 65
            |||||||||||:||.|||.||:||||.||:||||:|||||||||||:|||||||||:|.||.:||
Zfish     1 MVLADLGRKITSALRSLSNATIINEEVLNAMLKEVCAALLEADVNIKLVKQLRENVKAAIDLEEM 65

  Fly    66 AGGLNKRRMIQSAVFKELVKLVDPGVKPYQPIKGKANVVMFVGLQGSGKTTTCTKLAYHYQKRNW 130
            |.|||||||||.|||||||||||||||.:.|.|||.||:||||||||||||||:||||::|::.|
Zfish    66 ASGLNKRRMIQHAVFKELVKLVDPGVKAWTPTKGKNNVIMFVGLQGSGKTTTCSKLAYYFQRKGW 130

  Fly   131 KSCLVCADTFRAGAYDQVKQNATKARIPFYGSYTEIDPVVIAQDGVDMFKREGFEMIIVDTSGRH 195
            |:||:|||||||||:||:|||||||||||||||||:|||:||.:||:.||.|.||:|||||||||
Zfish   131 KTCLICADTFRAGAFDQLKQNATKARIPFYGSYTEMDPVIIAAEGVEKFKSENFEIIIVDTSGRH 195

  Fly   196 KQEESLFEEMLAVSNAVSPDNIIFVMDATIGQACEAQAKAFKDKVDIGSVIITKLDGHAKGGGAL 260
            |||:|||||||.|||||.||||::||||:|||||||||||||||||:.|||:|||||||||||||
Zfish   196 KQEDSLFEEMLQVSNAVQPDNIVYVMDASIGQACEAQAKAFKDKVDVASVIVTKLDGHAKGGGAL 260

  Fly   261 SAVAATQSPIIFIGTGEHIDDLEPFKTKPFVSKLLGMGDIEGLIDKVNELKLDGNDELLEKIKHG 325
            ||||||:||||||||||||||.|||||:||:||||||||||||||||||||||.|:||::|:|||
Zfish   261 SAVAATKSPIIFIGTGEHIDDFEPFKTQPFISKLLGMGDIEGLIDKVNELKLDDNEELIDKLKHG 325

  Fly   326 HFTIRDMYEQFQNIMKMGPFSQFMNMIPGFSQDFMTKGGEQESMARVKRMMTMMDSMSDNELDNR 390
            .||:||||||||||||||||.|.|.|||||..|||:||.|||||||:|::||:||||:|.||||:
Zfish   326 QFTLRDMYEQFQNIMKMGPFGQIMGMIPGFGTDFMSKGNEQESMARLKKLMTIMDSMNDQELDNK 390

  Fly   391 DGAKLFSKQPNRCVRVAQGAGVMEREVKELIAHYTKFSAVVKKMGGVKGLFKQGDMTKNVNPTQM 455
            ||||||||||||..|||:|:||..|:|:||:..||||:.:||||||:|||||.|||:|||||:||
Zfish   391 DGAKLFSKQPNRIQRVARGSGVATRDVQELLTQYTKFAQMVKKMGGIKGLFKGGDMSKNVNPSQM 455

  Fly   456 AKLNQQIAKMIDPRMLQQMGGVGGIQNMMRQLQQGAAGGLGGLGNLMSGF 505
            ||||||:|||:|||:|..|||:.|:|:||||.||||||.:.|    |.||
Zfish   456 AKLNQQMAKMMDPRVLHHMGGMAGLQSMMRQFQQGAAGNMKG----MMGF 501

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Srp54k	NP_523931.1	SRP54_euk	2..428	CDD:273615	341/425 (80%)
		SRP54_N	6..83	CDD:280954	62/76 (82%)
		SRP54	102..294	CDD:278855	158/191 (83%)
		SRP_SPB	327..428	CDD:281039	74/100 (74%)
srp54	NP_957282.1	G-domain. /evidence=ECO:0000250\|UniProtKB:P61011	1..295		241/293 (82%)
		SRP54_euk	2..430	CDD:273615	342/427 (80%)
		M-domain. /evidence=ECO:0000250\|UniProtKB:P61011	296..504		153/210 (73%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170576618
Domainoid	1	1.000	345	1.000	Domainoid score	I1021
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2362
Inparanoid	1	1.050	813	1.000	Inparanoid score	I465
OMA	1	1.010	-	-		QHG62209
OrthoDB	1	1.010	-	-		D224280at33208
OrthoFinder	1	1.000	-	-		FOG0002467
OrthoInspector	1	1.000	-	-		oto39990
orthoMCL	1	0.900	-	-		OOG6_100507
Panther	1	1.100	-	-	LDO	PTHR11564
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1391
SonicParanoid	1	1.000	-	-		X1645
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	14	13.940