DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Srp54k and F21D5.7

DIOPT Version :9

Sequence 1:	NP_523931.1	Gene:	Srp54k / 38593	FlyBaseID:	FBgn0010747	Length:	508	Species:	Drosophila melanogaster
Sequence 2:	NP_501507.1	Gene:	F21D5.7 / 259584	WormBaseID:	WBGene00009012	Length:	496	Species:	Caenorhabditis elegans

Alignment Length:	490	Identity:	342/490 - (69%)
Similarity:	417/490 - (85%)	Gaps:	3/490 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MVLADLGRKITTALHSLSKATVINEEALNSMLKEICAALLEADVNIRLVKQLRENVRAVIDFDEM 65
            ||||||||||..|:..|.::|||||..|:.||||:|.||:|:||:|||||||::||:..|:|:|:
Worm     1 MVLADLGRKIRNAIGKLGQSTVINEGELDLMLKEVCTALIESDVHIRLVKQLKDNVKKAINFEEI 65

  Fly    66 AGGLNKRRMIQSAVFKELVKLVDPGVKPYQPIKGKANVVMFVGLQGSGKTTTCTKLAYHYQKRNW 130
            .||.||||.||..||.||:|||||||.|:.|.||:.||.||||||||||||||||:||:||::.|
Worm    66 VGGANKRRYIQKTVFNELLKLVDPGVTPFTPTKGRRNVFMFVGLQGSGKTTTCTKMAYYYQRKGW 130

  Fly   131 KSCLVCADTFRAGAYDQVKQNATKARIPFYGSYTEIDPVVIAQDGVDMFKREGFEMIIVDTSGRH 195
            |:||:|||||||||:||:|||||||||||||||:|||||.||.:||:.|.:||||:|||||||||
Worm   131 KTCLICADTFRAGAFDQLKQNATKARIPFYGSYSEIDPVKIAAEGVEKFTQEGFEIIIVDTSGRH 195

  Fly   196 KQEESLFEEMLAVSNAVSPDNIIFVMDATIGQACEAQAKAFKDKVDIGSVIITKLDGHAKGGGAL 260
            |||.|||||||.|||||:|||::|||||:|||||||||:||...||:.||||||||.||||||||
Worm   196 KQEASLFEEMLQVSNAVTPDNVVFVMDASIGQACEAQARAFSQTVDVASVIITKLDSHAKGGGAL 260

  Fly   261 SAVAATQSPIIFIGTGEHIDDLEPFKTKPFVSKLLGMGDIEGLIDKVNELKLDGNDELLEKIKHG 325
            ||||.|:||:|||||||||||.|.||.|.||.||||||||.||:|.||::.:..|.||:.::|.|
Worm   261 SAVAVTKSPVIFIGTGEHIDDFEIFKPKSFVQKLLGMGDIAGLVDMVNDIGIQDNKELVGRLKQG 325

  Fly   326 HFTIRDMYEQFQNIMKMGPFSQFMNMIPGFSQDFMTKGGEQESMARVKRMMTMMDSMSDNELDNR 390
            .||:||||||||||||||||||.|.|||||..:|||||.||||:.|:|||||:||||||.|||:.
Worm   326 QFTLRDMYEQFQNIMKMGPFSQIMGMIPGFGSEFMTKGNEQESVNRLKRMMTVMDSMSDKELDHP 390

  Fly   391 DGAKLFSKQPNRCVRVAQGAGVMEREVKELIAHYTKFSAVVKKMGGVKGLF--KQGDMT-KNVNP 452
            ..::||:|:|||..|||:|:|..::||::|:|.|.|||.||||:|.:||||  |.||:. ||:||
Worm   391 KASELFTKEPNRVARVARGSGSHQQEVRDLLAQYKKFSDVVKKIGSIKGLFNGKNGDINPKNMNP 455

  Fly   453 TQMAKLNQQIAKMIDPRMLQQMGGVGGIQNMMRQL 487
            .:||:||||:|||:|||:||||||:||:||||:|:
Worm   456 AKMAQLNQQMAKMMDPRVLQQMGGMGGLQNMMQQM 490

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Srp54k	NP_523931.1	SRP54_euk	2..428	CDD:273615	298/425 (70%)
		SRP54_N	6..83	CDD:280954	45/76 (59%)
		SRP54	102..294	CDD:278855	151/191 (79%)
		SRP_SPB	327..428	CDD:281039	67/100 (67%)
F21D5.7	NP_501507.1	SRP54_euk	2..428	CDD:273615	298/425 (70%)
		SRP54_N	6..83	CDD:280954	45/76 (59%)
		SRP54	102..294	CDD:278855	151/191 (79%)
		SRP_SPB	326..428	CDD:281039	67/101 (66%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160157796
Domainoid	1	1.000	324	1.000	Domainoid score	I644
eggNOG	1	0.900	-	-		E1_COG0541
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2362
Inparanoid	1	1.050	702	1.000	Inparanoid score	I344
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG62209
OrthoDB	1	1.010	-	-		D224280at33208
OrthoFinder	1	1.000	-	-		FOG0002467
OrthoInspector	1	1.000	-	-		oto18693
orthoMCL	1	0.900	-	-		OOG6_100507
Panther	1	1.100	-	-	LDO	PTHR11564
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1391
SonicParanoid	1	1.000	-	-		X1645
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	16	15.840