Protein Alignment Con and TRIL

DIOPT Version :10

• Sequence 1: NP_523930.3
• Gene: Con / 38590
• FlyBaseID: FBgn0005775
• Length: 691
• Species: Drosophila melanogaster
• Sequence 2: NP_055632.2
• Gene: TRIL / 9865
• HGNCID: 22200
• Length: 811
• Species: Homo sapiens
• Alignment Length: 461
• Identity: 110/461 - (23%)
• Similarity: 173/461 - (37%)
• Gaps: 111/461 - (24%)

  Fly   182 LKNLSSIVIEYSQVEIVKSYAFANLPFLERIILNNNHIMALDQDAFANHIRLRELNLEHNQIFEM 246
            |..|..:.::|:|:..:....|..|..||.:.|.||.:.||.....|...:||.|....|:|..:
Human    82 LGQLRRLDLQYNQIRSLHPKTFEKLSRLEELYLGNNLLQALAPGTLAPLRKLRILYANGNEISRL 146

  Fly   247 DRYAFRNLPLCERLFLNNNNISTLHEGLFADMARLTFLNLAHNQINVLTSEIFRGLGNLNVLK-- 309
            .|.:|..|....:|.|:.|.:..|.:.:||.:..|.:|:|..|:|..|....|..||.|..|.
Human   147 SRGSFEGLESLVKLRLDGNALGALPDAVFAPLGNLLYLHLESNRIRFLGKNAFAQLGKLRFLNLS 211

  Fly   310 ------------------------LTRNNLNFIGDTVFAELWSLSELELDDNRIERISERALDGL 350
                                    |:.|||..:|..:|..|..|..|.|..|::..::..|..||
Human   212 ANELQPSLRHAATFAPLRSLSSLILSANNLQHLGPRIFQHLPRLGLLSLRGNQLTHLAPEAFWGL 276

  Fly   351 NTLKTLNLRNNLLKKIDNGLLRGTPALLSINVQANKLETLTFYTF--------QPIMDNLVNSTS 407
            ..|:.|.|..|.|.::...||....:|.::::..|:|..|...||        ..:.:|.:::.|
Human   277 EALRELRLEGNRLSQLPTALLEPLHSLEALDLSGNELSALHPATFGHLGRLRELSLRNNALSALS 341

  Fly   408 -----------ELLVSDNKFICDCRL----QWIFELKNRTRHL----QLR----------DSLED 443
                       .|.:..|.:.|||||    :|:.:..::.|.|    |.|          |.|:|
Human   342 GDIFAASPALYRLDLDGNGWTCDCRLRGLKRWMGDWHSQGRLLTVFVQCRHPPALRGKYLDYLDD 406

  Fly   444 LH-----CTLQEPKLSHFVD----PVPPTILDVLNIGGFTAIGSNSASMGGVGNSV--------V 491
            ..     |....|..|...|    |:|            ||.|.......|:...:        .
Human   407 QQLQNGSCADPSPSASLTADRRRQPLP------------TAAGEEMTPPAGLAEELPPQPQLQQQ 459

  Fly   492 GSSYSGLTMDDSRKHL-GSRSRQALRGQRQFASSAENVVESKMRRRRKRQEEVKEKDLAAVAPAH 555
            |...:|:..|.:.:.| |:||  |||                :.||....::......||..||.
Human   460 GRFLAGVAWDGAARELVGNRS--ALR----------------LSRRGPGLQQPSPSVAAAAGPAP 506

  Fly   556 KRYDYY 561
            :..|.:
Human   507 QSLDLH 512

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Con	NP_523930.3	LRR	<157..459	CDD:443914	87/348 (25%)
		leucine-rich repeat	185..208	CDD:275380	5/22 (23%)
		leucine-rich repeat	209..232	CDD:275380	8/22 (36%)
		leucine-rich repeat	233..256	CDD:275380	8/22 (36%)
		leucine-rich repeat	257..280	CDD:275380	6/22 (27%)
		leucine-rich repeat	281..304	CDD:275380	8/22 (36%)
		leucine-rich repeat	305..328	CDD:275380	9/48 (19%)
		leucine-rich repeat	329..352	CDD:275380	7/22 (32%)
		leucine-rich repeat	353..376	CDD:275380	7/22 (32%)
TRIL	NP_055632.2	leucine-rich repeat	37..61	CDD:275380
		LRR	61..>344	CDD:443914	68/261 (26%)
		LRR 1	61..81
		leucine-rich repeat	62..84	CDD:275380	1/1 (100%)
		LRR 2	84..105		4/20 (20%)
		leucine-rich repeat	85..108	CDD:275380	5/22 (23%)
		LRR 3	108..129		7/20 (35%)
		leucine-rich repeat	109..132	CDD:275380	8/22 (36%)
		LRR 4	132..153		7/20 (35%)
		leucine-rich repeat	133..156	CDD:275380	8/22 (36%)
		LRR 5	156..177		5/20 (25%)
		leucine-rich repeat	157..180	CDD:275380	6/22 (27%)
		LRR 6	180..201		7/20 (35%)
		leucine-rich repeat	181..204	CDD:275380	8/22 (36%)
		LRR 7	204..223		2/18 (11%)
		leucine-rich repeat	205..254	CDD:275380	9/48 (19%)
		LRR 8	230..251		6/20 (30%)
		LRR 9	254..275		5/20 (25%)
		leucine-rich repeat	255..278	CDD:275380	7/22 (32%)
		LRR 10	278..299		7/20 (35%)
		leucine-rich repeat	279..302	CDD:275380	7/22 (32%)
		LRR 11	302..323		6/20 (30%)
		leucine-rich repeat	303..326	CDD:275380	6/22 (27%)
		LRR 12	326..347		2/20 (10%)
		leucine-rich repeat	327..346	CDD:275380	2/18 (11%)
		PCC	332..>401	CDD:188093	14/68 (21%)
		leucine-rich repeat	351..363	CDD:275378	2/11 (18%)
		PHA03378	<478..>579	CDD:223065	12/53 (23%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	484..549		7/29 (24%)
		FN3	589..667	CDD:473895