Protein Alignment Con and LRIG2

DIOPT Version :10

• Sequence 1: NP_523930.3
• Gene: Con / 38590
• FlyBaseID: FBgn0005775
• Length: 691
• Species: Drosophila melanogaster
• Sequence 2: NP_055628.1
• Gene: LRIG2 / 9860
• HGNCID: 20889
• Length: 1065
• Species: Homo sapiens
• Alignment Length: 507
• Identity: 111/507 - (21%)
• Similarity: 194/507 - (38%)
• Gaps: 159/507 - (31%)

  Fly   109 CTRRRDMKLMCYCTPDENHVPVQKAECWVFSEGL-----------HQNDTTWTRFYQQKRLRELK 162
            |:||:              :|   |..|....||           |...:.|....:.:.|:|:|
Human    56 CSRRK--------------LP---APSWRALSGLLPPDTAILDFSHNRLSNWNISLESQTLQEVK 103

  Fly   163 FVIQNNARLDYIPTMIIEPLKNLSSIVIEYSQVEIVKSYAFANLPFLERIILNNNHIMALDQDAF 227
               .|...|..|| ...||..|::.:.:.::.:..:.:.|....|.||.:.|::|.|..:...:|
Human   104 ---MNYNELTEIP-YFGEPTSNITLLSLVHNIIPEINAQALQFYPALESLDLSSNIISEIKTSSF 164

  Fly   228 ANHIRLRELNLEHNQIFEMDRYAFRNLPLCERLF-LNNNNISTLHEGLFADMARLTFLNLAHNQI 291
            . .::|:.|||.:|:|..::...|.||.....:. ||.|.:|.:...:| .:..|.||.|..|:|
Human   165 P-RMQLKYLNLSNNRITTLEAGCFDNLSSSLLVVKLNRNRMSMIPPKIF-KLPHLQFLELKRNRI 227

  Fly   292 NVLTSEIFRGLGNLNVLKLTRNNLNFIGDTVF--------------------------------- 323
            .::....|:||.:|..||:.||.::.:.|..|
Human   228 KIVEGLTFQGLDSLRSLKMQRNGISKLKDGAFFGLNNMEELELEHNNLTRVNKGWLYGLRMLQQL 292

  Fly   324 -----------AELWS----LSELELDDNRIERISERALDGLNTLKTLNLRNNLLKKIDNGLLR- 372
                       .:.|.    ||||:|..|::.|:.|.|..||:.|:.|||.:|.:..|.:|:.|
Human   293 YVSQNAIERISPDAWEFCQRLSELDLSYNQLTRLDESAFVGLSLLERLNLGDNRVTHIADGVFRF 357

  Fly   373 --------------------------GTPALLSINVQANKLETLTFYTF---------------- 395
                                      |..:|..:.:|.|:::::|...|
Human   358 LSNLQTLDLRNNEISWAIEDASEAFAGLTSLTKLILQGNQIKSITKKAFIGLESLEHLDLNNNAI 422

  Fly   396 QPIMDNLVNST--SELLVSDNKFICDCRLQWIFE--LKNRTRHLQ---------------LRDSL 441
            ..|.:|..:.|  .||:::.:..:|||.|:|:.:  :.|..:|..               |...|
Human   423 MSIQENAFSQTHLKELILNTSSLLCDCHLKWLLQWLVDNNFQHSVNVSCAHPEWLAGQSILNVDL 487

  Fly   442 EDLHCTLQEPKLSHFVDPV----PPTILDV--LNIG-GFTAIGSNSASMGGV 486
            :|..|       ..|:.|.    |.||:.:  :|:. ..||:.|:.:.|..|
Human   488 KDFVC-------DDFLKPQIRTHPETIIALRGMNVTLTCTAVSSSDSPMSTV 532

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Con	NP_523930.3	LRR	<157..459	CDD:443914	91/412 (22%)
		leucine-rich repeat	185..208	CDD:275380	1/22 (5%)
		leucine-rich repeat	209..232	CDD:275380	6/22 (27%)
		leucine-rich repeat	233..256	CDD:275380	9/22 (41%)
		leucine-rich repeat	257..280	CDD:275380	5/23 (22%)
		leucine-rich repeat	281..304	CDD:275380	9/22 (41%)
		leucine-rich repeat	305..328	CDD:275380	7/66 (11%)
		leucine-rich repeat	329..352	CDD:275380	11/22 (50%)
		leucine-rich repeat	353..376	CDD:275380	9/49 (18%)
LRIG2	NP_055628.1	RNA1	<54..184	CDD:444072	34/149 (23%)
		LRR 1	76..97		2/20 (10%)
		LRR 2	98..119		8/24 (33%)
		leucine-rich repeat	99..121	CDD:275378	9/25 (36%)
		LRR	121..552	CDD:443914	92/421 (22%)
		LRR 3	121..142		2/20 (10%)
		leucine-rich repeat	122..145	CDD:275378	1/22 (5%)
		LRR 4	145..166		6/21 (29%)
		leucine-rich repeat	146..168	CDD:275380	6/22 (27%)
		LRR 5	168..189		7/20 (35%)
		leucine-rich repeat	169..192	CDD:275380	9/22 (41%)
		LRR 6	193..214		5/21 (24%)
		leucine-rich repeat	194..216	CDD:275380	5/22 (23%)
		LRR 7	216..237		7/20 (35%)
		leucine-rich repeat	217..240	CDD:275380	9/22 (41%)
		LRR 8	240..261		7/20 (35%)
		leucine-rich repeat	241..264	CDD:275380	7/22 (32%)
		LRR 9	264..285		0/20 (0%)
		leucine-rich repeat	265..288	CDD:275380	0/22 (0%)
		LRR 10	288..309		1/20 (5%)
		leucine-rich repeat	289..312	CDD:275380	1/22 (5%)
		LRR 11	312..333		9/20 (45%)
		leucine-rich repeat	313..336	CDD:275380	11/22 (50%)
		LRR 12	336..357		7/20 (35%)
		leucine-rich repeat	337..360	CDD:275380	8/22 (36%)
		LRR 13	360..382		0/21 (0%)
		leucine-rich repeat	361..385	CDD:275380	0/23 (0%)
		LRR 14	387..408		5/20 (25%)
		leucine-rich repeat	388..411	CDD:275380	5/22 (23%)
		LRR 15	411..432		2/20 (10%)
		leucine-rich repeat	412..434	CDD:275380	2/21 (10%)
		Ig	509..598	CDD:472250	6/24 (25%)
		Ig strand B	515..519	CDD:409353	0/3 (0%)
		Ig strand C	530..534	CDD:409353	1/3 (33%)
		Ig strand E	563..567	CDD:409353
		Ig strand F	577..582	CDD:409353
		Ig strand G	589..594	CDD:409353
		IgI_LRIG1-like	603..693	CDD:409420
		Ig strand A	603..606	CDD:409420
		Ig strand A'	610..614	CDD:409420
		Ig strand B	617..626	CDD:409420
		Ig strand C	632..637	CDD:409420
		Ig strand C'	640..642	CDD:409420
		Ig strand D	650..654	CDD:409420
		Ig strand E	658..665	CDD:409420
		Ig strand F	671..679	CDD:409420
		Ig strand G	682..693	CDD:409420
		I-set	696..783	CDD:400151
		Ig strand B	713..717	CDD:409353
		Ig strand C	726..730	CDD:409353
		Ig strand E	749..753	CDD:409353
		Ig strand F	763..768	CDD:409353
		Ig strand G	776..779	CDD:409353
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	963..990
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1003..1040