DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Con and LRIG2

DIOPT Version :9

Sequence 1:	NP_001246635.1	Gene:	Con / 38590	FlyBaseID:	FBgn0005775	Length:	691	Species:	Drosophila melanogaster
Sequence 2:	NP_055628.1	Gene:	LRIG2 / 9860	HGNCID:	20889	Length:	1065	Species:	Homo sapiens

Alignment Length:	507	Identity:	111/507 - (21%)
Similarity:	194/507 - (38%)	Gaps:	159/507 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   109 CTRRRDMKLMCYCTPDENHVPVQKAECWVFSEGL-----------HQNDTTWTRFYQQKRLRELK 162
            |:||:              :|   |..|....||           |...:.|....:.:.|:|:|
Human    56 CSRRK--------------LP---APSWRALSGLLPPDTAILDFSHNRLSNWNISLESQTLQEVK 103

  Fly   163 FVIQNNARLDYIPTMIIEPLKNLSSIVIEYSQVEIVKSYAFANLPFLERIILNNNHIMALDQDAF 227
               .|...|..|| ...||..|::.:.:.::.:..:.:.|....|.||.:.|::|.|..:...:|
Human   104 ---MNYNELTEIP-YFGEPTSNITLLSLVHNIIPEINAQALQFYPALESLDLSSNIISEIKTSSF 164

  Fly   228 ANHIRLRELNLEHNQIFEMDRYAFRNLPLCERLF-LNNNNISTLHEGLFADMARLTFLNLAHNQI 291
            . .::|:.|||.:|:|..::...|.||.....:. ||.|.:|.:...:| .:..|.||.|..|:|
Human   165 P-RMQLKYLNLSNNRITTLEAGCFDNLSSSLLVVKLNRNRMSMIPPKIF-KLPHLQFLELKRNRI 227

  Fly   292 NVLTSEIFRGLGNLNVLKLTRNNLNFIGDTVF--------------------------------- 323
            .::....|:||.:|..||:.||.::.:.|..|
Human   228 KIVEGLTFQGLDSLRSLKMQRNGISKLKDGAFFGLNNMEELELEHNNLTRVNKGWLYGLRMLQQL 292

  Fly   324 -----------AELWS----LSELELDDNRIERISERALDGLNTLKTLNLRNNLLKKIDNGLLR- 372
                       .:.|.    ||||:|..|::.|:.|.|..||:.|:.|||.:|.:..|.:|:.|
Human   293 YVSQNAIERISPDAWEFCQRLSELDLSYNQLTRLDESAFVGLSLLERLNLGDNRVTHIADGVFRF 357

  Fly   373 --------------------------GTPALLSINVQANKLETLTFYTF---------------- 395
                                      |..:|..:.:|.|:::::|...|
Human   358 LSNLQTLDLRNNEISWAIEDASEAFAGLTSLTKLILQGNQIKSITKKAFIGLESLEHLDLNNNAI 422

  Fly   396 QPIMDNLVNST--SELLVSDNKFICDCRLQWIFE--LKNRTRHLQ---------------LRDSL 441
            ..|.:|..:.|  .||:::.:..:|||.|:|:.:  :.|..:|..               |...|
Human   423 MSIQENAFSQTHLKELILNTSSLLCDCHLKWLLQWLVDNNFQHSVNVSCAHPEWLAGQSILNVDL 487

  Fly   442 EDLHCTLQEPKLSHFVDPV----PPTILDV--LNIG-GFTAIGSNSASMGGV 486
            :|..|       ..|:.|.    |.||:.:  :|:. ..||:.|:.:.|..|
Human   488 KDFVC-------DDFLKPQIRTHPETIIALRGMNVTLTCTAVSSSDSPMSTV 532

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Con	NP_001246635.1	LRR_RI	<147..291	CDD:238064	38/144 (26%)
		LRR_8	183..243	CDD:290566	14/59 (24%)
		leucine-rich repeat	185..208	CDD:275380	1/22 (5%)
		leucine-rich repeat	209..232	CDD:275380	6/22 (27%)
		LRR_RI	<225..416	CDD:238064	62/284 (22%)
		LRR_8	232..291	CDD:290566	19/59 (32%)
		leucine-rich repeat	233..256	CDD:275380	9/22 (41%)
		leucine-rich repeat	257..280	CDD:275380	5/23 (22%)
		leucine-rich repeat	281..304	CDD:275380	9/22 (41%)
		LRR_8	304..363	CDD:290566	24/106 (23%)
		leucine-rich repeat	305..328	CDD:275380	7/66 (11%)
		leucine-rich repeat	329..352	CDD:275380	11/22 (50%)
		LRR_8	352..416	CDD:290566	19/108 (18%)
		leucine-rich repeat	353..376	CDD:275380	9/49 (18%)
		LRRCT	414..>450	CDD:214507	11/52 (21%)
LRIG2	NP_055628.1	LRR_RI	<46..205	CDD:238064	40/170 (24%)
		LRR 1	76..97		2/20 (10%)
		LRR 2	98..119		8/24 (33%)
		leucine-rich repeat	99..121	CDD:275380	9/25 (36%)
		LRR_8	120..179	CDD:290566	14/59 (24%)
		LRR 3	121..142		2/20 (10%)
		leucine-rich repeat	122..145	CDD:275378	1/22 (5%)
		LRR 4	145..166		6/21 (29%)
		leucine-rich repeat	146..168	CDD:275380	6/22 (27%)
		LRR_8	168..251	CDD:290566	28/83 (34%)
		LRR 5	168..189		7/20 (35%)
		leucine-rich repeat	169..192	CDD:275380	9/22 (41%)
		LRR 6	193..214		5/21 (24%)
		leucine-rich repeat	194..216	CDD:275380	5/22 (23%)
		LRR 7	216..237		7/20 (35%)
		leucine-rich repeat	217..240	CDD:275380	9/22 (41%)
		LRR_8	240..299	CDD:290566	7/58 (12%)
		LRR 8	240..261		7/20 (35%)
		leucine-rich repeat	241..264	CDD:275380	7/22 (32%)
		LRR 9	264..285		0/20 (0%)
		leucine-rich repeat	265..288	CDD:275380	0/22 (0%)
		LRR_RI	266..492	CDD:238064	41/225 (18%)
		LRR 10	288..309		1/20 (5%)
		leucine-rich repeat	289..312	CDD:275380	1/22 (5%)
		LRR_8	312..371	CDD:290566	19/58 (33%)
		LRR 11	312..333		9/20 (45%)
		leucine-rich repeat	313..336	CDD:275380	11/22 (50%)
		LRR 12	336..357		7/20 (35%)
		leucine-rich repeat	337..360	CDD:275380	8/22 (36%)
		LRR_8	359..422	CDD:290566	6/62 (10%)
		LRR 13	360..382		0/21 (0%)
		leucine-rich repeat	361..385	CDD:275380	0/23 (0%)
		LRR 14	387..408		5/20 (25%)
		leucine-rich repeat	388..411	CDD:275380	5/22 (23%)
		LRR 15	411..432		2/20 (10%)
		leucine-rich repeat	412..434	CDD:275380	2/21 (10%)
		LRRCT	445..493	CDD:214507	11/54 (20%)
		Ig	502..598	CDD:299845	9/31 (29%)
		IG	504..598	CDD:214652	9/29 (31%)
		I-set	602..692	CDD:254352
		Ig_1	619..693	CDD:143240
		I-set	696..783	CDD:254352
		Ig	714..783	CDD:299845
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	962..990
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1003..1040
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165141301
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.840