Protein Alignment Con and LGI1

DIOPT Version :10

• Sequence 1: NP_523930.3
• Gene: Con / 38590
• FlyBaseID: FBgn0005775
• Length: 691
• Species: Drosophila melanogaster
• Sequence 2: NP_005088.1
• Gene: LGI1 / 9211
• HGNCID: 6572
• Length: 557
• Species: Homo sapiens
• Alignment Length: 191
• Identity: 45/191 - (23%)
• Similarity: 80/191 - (41%)
• Gaps: 44/191 - (23%)

  Fly   256 LCERLFLNNNNISTLHEGLFADMARLTFLNLAHNQINVLTSEIFRGLGNLNVLKLTRNNLNFIGD 320
            |||       |..::...:..|:..|:|:.....:|   :...|....:|.:|..|.|:.:.|.|
Human    54 LCE-------NARSIPRTVPPDVISLSFVRSGFTEI---SEGSFLFTPSLQLLLFTSNSFDVISD 108

  Fly   321 TVFAELWSLSELELDDNRIERISERALDGLNTLKTLNLRNNLLKKIDNGLLRGTPALLSINVQAN 385
            ..|..|..|..|.:::|.|:.||.....||.:|..|:|.||.|:.:...:.:|..:|.:::::.
Human   109 DAFIGLPHLEYLFIENNNIKSISRHTFRGLKSLIHLSLANNNLQTLPKDIFKGLDSLTNVDLRG- 172

  Fly   386 KLETLTFYTFQPIMDNLVNSTSELLVSDNKFICDCRLQWIFELKNRTRHLQLRDSLEDLHC 446
                                        |.|.|||:|:|:.|....|     ..::||::|
Human   173 ----------------------------NSFNCDCKLKWLVEWLGHT-----NATVEDIYC 200

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Con	NP_523930.3	LRR	<157..459	CDD:443914	45/191 (24%)
		leucine-rich repeat	185..208	CDD:275380
		leucine-rich repeat	209..232	CDD:275380
		leucine-rich repeat	233..256	CDD:275380	45/191 (24%)
		leucine-rich repeat	257..280	CDD:275380	4/22 (18%)
		leucine-rich repeat	281..304	CDD:275380	4/22 (18%)
		leucine-rich repeat	305..328	CDD:275380	8/22 (36%)
		leucine-rich repeat	329..352	CDD:275380	8/22 (36%)
		leucine-rich repeat	353..376	CDD:275380	7/22 (32%)
LGI1	NP_005088.1	leucine-rich repeat	71..92	CDD:275378	4/23 (17%)
		LRR_8	91..151	CDD:404697	21/59 (36%)
		LRR 1	92..113		7/20 (35%)
		leucine-rich repeat	93..116	CDD:275378	8/22 (36%)
		LRR 2	116..137		6/20 (30%)
		leucine-rich repeat	117..140	CDD:275378	8/22 (36%)
		LRR 3	140..161		6/20 (30%)
		leucine-rich repeat	141..164	CDD:275378	7/22 (32%)
		PCC	146..>221	CDD:188093	18/89 (20%)
		leucine-rich repeat	165..177	CDD:275378	3/40 (8%)
		EAR 1. /evidence=ECO:0000255|PROSITE-ProRule:PRU00075	225..267
		EPTP	225..265	CDD:461033
		EAR 2. /evidence=ECO:0000255|PROSITE-ProRule:PRU00075	271..313
		EPTP	272..310	CDD:461033
		EAR 3. /evidence=ECO:0000255|PROSITE-ProRule:PRU00075	317..364
		EPTP	317..362	CDD:461033
		EAR 4. /evidence=ECO:0000255|PROSITE-ProRule:PRU00075	366..415
		EPTP	366..413	CDD:461033
		EAR 5. /evidence=ECO:0000255|PROSITE-ProRule:PRU00075	419..462
		EPTP	420..460	CDD:461033
		EAR 6. /evidence=ECO:0000255|PROSITE-ProRule:PRU00075	464..506
		EPTP	465..504	CDD:461033
		EAR 7. /evidence=ECO:0000255|PROSITE-ProRule:PRU00075	510..552
		EPTP	510..550	CDD:461033