DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Con and LGR5

DIOPT Version :9

Sequence 1:	NP_001246635.1	Gene:	Con / 38590	FlyBaseID:	FBgn0005775	Length:	691	Species:	Drosophila melanogaster
Sequence 2:	NP_003658.1	Gene:	LGR5 / 8549	HGNCID:	4504	Length:	907	Species:	Homo sapiens

Alignment Length:	495	Identity:	126/495 - (25%)
Similarity:	193/495 - (38%)	Gaps:	100/495 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    96 STGYSGPMDSTGFCTRRRDMKLMCYCTPDENHVPVQKAEC------------WVFSEGLH----- 143
            :||.|.|...    ...|.....|:|.||..  .:.:.:|            .||:..|.
Human    19 ATGGSSPRSG----VLLRGCPTHCHCEPDGR--MLLRVDCSDLGLSELPSNLSVFTSYLDLSMNN 77

  Fly   144 -----QNDTTWTRFYQQKRLRELKFVIQNNARLDYIPTMIIEPLKNLSSIVIEYSQVEIVKSYAF 203
                 .|.....||.::.||       ..|| |.|||......|.:|..::::.:|:..|.:.|.
Human    78 ISQLLPNPLPSLRFLEELRL-------AGNA-LTYIPKGAFTGLYSLKVLMLQNNQLRHVPTEAL 134

  Fly   204 ANLPFLERIILNNNHIMALDQDAFANHIRLRELNLEHNQIFEMDRYAFRNLPLCERLFLNNNNIS 268
            .||..|:.:.|:.|||..:....|:....||.|.|:.|.:.|:...|||:|...:.:.|..|.|.
Human   135 QNLRSLQSLRLDANHISYVPPSCFSGLHSLRHLWLDDNALTEIPVQAFRSLSALQAMTLALNKIH 199

  Fly   269 TLHEGLFADMARLTFLNLAHNQINVLTSEIFRGLGNLNVLKLTRNNLNFIGDTVFAELWSLSELE 333
            .:.:..|.:::.|..|:|.:|:|:.|..:.|.||.:|..|.|..|||:.. .|....|.:|.||.
Human   200 HIPDYAFGNLSSLVVLHLHNNRIHSLGKKCFDGLHSLETLDLNYNNLDEF-PTAIRTLSNLKELG 263

  Fly   334 LDDNRIERISERALDGLNTLKTLNLRNNLLKKIDNGLLRGTPALLSINVQ--------------A 384
            ...|.|..|.|:|..|..:|.|::..:|.::.:.....:..|.|.::.:.              |
Human   264 FHSNNIRSIPEKAFVGNPSLITIHFYDNPIQFVGRSAFQHLPELRTLTLNGASQITEFPDLTGTA 328

  Fly   385 NKLETLTFYTFQ--PIMDNLVNSTSELLVSDNKF----------IC------DCRLQWIFELKNR 431
            | ||:||....|  .:...:.|....|.|.|..:          :|      |.|...|:|:|..
Human   329 N-LESLTLTGAQISSLPQTVCNQLPNLQVLDLSYNLLEDLPSFSVCQKLQKIDLRHNEIYEIKVD 392

  Fly   432 TRHLQLRDSLEDLHCTLQEPKLSH--FVDPVPPTI-LDVLNIGGFTAIGSNSASMGGVGNSVVGS 493
            |  .|...||..|:....:..:.|  ....:|..| ||         :.||..|      |...:
Human   393 T--FQQLLSLRSLNLAWNKIAIIHPNAFSTLPSLIKLD---------LSSNLLS------SFPIT 440

  Fly   494 SYSGLTMDDSRKHLGSRSRQALRGQRQFASSAENVVESKM 533
            ...|||      ||......||    |...|:||..|.|:
Human   441 GLHGLT------HLKLTGNHAL----QSLISSENFPELKV 470

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Con	NP_001246635.1	LRR_RI	<147..291	CDD:238064	41/143 (29%)
		LRR_8	183..243	CDD:290566	17/59 (29%)
		leucine-rich repeat	185..208	CDD:275380	6/22 (27%)
		leucine-rich repeat	209..232	CDD:275380	6/22 (27%)
		LRR_RI	<225..416	CDD:238064	57/206 (28%)
		LRR_8	232..291	CDD:290566	18/58 (31%)
		leucine-rich repeat	233..256	CDD:275380	10/22 (45%)
		leucine-rich repeat	257..280	CDD:275380	4/22 (18%)
		leucine-rich repeat	281..304	CDD:275380	9/22 (41%)
		LRR_8	304..363	CDD:290566	20/58 (34%)
		leucine-rich repeat	305..328	CDD:275380	8/22 (36%)
		leucine-rich repeat	329..352	CDD:275380	9/22 (41%)
		LRR_8	352..416	CDD:290566	16/79 (20%)
		leucine-rich repeat	353..376	CDD:275380	3/22 (14%)
		LRRCT	414..>450	CDD:214507	11/51 (22%)
LGR5	NP_003658.1	LRRNT	33..70	CDD:214470	7/38 (18%)
		leucine-rich repeat	68..91	CDD:275380	2/22 (9%)
		PLN00113	71..>426	CDD:215061	94/366 (26%)
		leucine-rich repeat	92..115	CDD:275380	9/30 (30%)
		leucine-rich repeat	116..139	CDD:275380	6/22 (27%)
		leucine-rich repeat	140..163	CDD:275380	6/22 (27%)
		leucine-rich repeat	164..187	CDD:275380	10/22 (45%)
		leucine-rich repeat	188..211	CDD:275380	4/22 (18%)
		leucine-rich repeat	212..235	CDD:275380	9/22 (41%)
		leucine-rich repeat	236..258	CDD:275380	8/22 (36%)
		leucine-rich repeat	259..282	CDD:275380	9/22 (41%)
		leucine-rich repeat	283..304	CDD:275380	3/20 (15%)
		leucine-rich repeat	307..353	CDD:275378	9/46 (20%)
		leucine-rich repeat	354..375	CDD:275378	4/20 (20%)
		leucine-rich repeat	376..389	CDD:275378	3/12 (25%)
		leucine-rich repeat	400..423	CDD:275378	3/22 (14%)
		leucine-rich repeat	445..459	CDD:275378	7/23 (30%)
		7tmA_LGR5	558..831	CDD:320485
		TM helix 1	559..585	CDD:320485
		TM helix 2	592..617	CDD:320485
		TM helix 3	637..667	CDD:320485
		TM helix 4	679..701	CDD:320485
		TM helix 5	721..750	CDD:320485
		TM helix 6	759..789	CDD:320485
		TM helix 7	799..824	CDD:320485
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165141329
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.930