DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Con and lgi1

DIOPT Version :9

Sequence 1:	NP_001246635.1	Gene:	Con / 38590	FlyBaseID:	FBgn0005775	Length:	691	Species:	Drosophila melanogaster
Sequence 2:	NP_001072366.1	Gene:	lgi1 / 779819	XenbaseID:	XB-GENE-954918	Length:	547	Species:	Xenopus tropicalis

Alignment Length:	191	Identity:	45/191 - (23%)
Similarity:	82/191 - (42%)	Gaps:	44/191 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   256 LCERLFLNNNNISTLHEGLFADMARLTFLNLAHNQINVLTSEIFRGLGNLNVLKLTRNNLNFIGD 320
            |||       |..::......|:..|:|:   .::...:....|..:.:|.:|..|.|..:.|.|
Frog    49 LCE-------NAKSIPRTFLPDVISLSFV---RSEFTEIPEGSFLHIPSLQLLLFTSNAFDAISD 103

  Fly   321 TVFAELWSLSELELDDNRIERISERALDGLNTLKTLNLRNNLLKKIDNGLLRGTPALLSINVQAN 385
            ..|..|..|..|.:::|:|:.||..|..||.:|..|:|.||.|:.:...:.:|..:|.:::::.
Frog   104 DAFTGLPHLEYLFIENNKIKSISRNAFRGLKSLIHLSLANNNLQSLPKDVFKGLDSLTNVDLRG- 167

  Fly   386 KLETLTFYTFQPIMDNLVNSTSELLVSDNKFICDCRLQWIFELKNRTRHLQLRDSLEDLHC 446
                                        |.|.|||:|:|:.|..::|     ..::|.:||
Frog   168 ----------------------------NAFHCDCKLKWLVEWLDKT-----NATVEQIHC 195

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Con	NP_001246635.1	LRR_RI	<147..291	CDD:238064	7/34 (21%)
		LRR_8	183..243	CDD:290566
		leucine-rich repeat	185..208	CDD:275380
		leucine-rich repeat	209..232	CDD:275380
		LRR_RI	<225..416	CDD:238064	34/159 (21%)
		LRR_8	232..291	CDD:290566	7/34 (21%)
		leucine-rich repeat	233..256	CDD:275380	45/191 (24%)
		leucine-rich repeat	257..280	CDD:275380	4/22 (18%)
		leucine-rich repeat	281..304	CDD:275380	3/22 (14%)
		LRR_8	304..363	CDD:290566	22/58 (38%)
		leucine-rich repeat	305..328	CDD:275380	8/22 (36%)
		leucine-rich repeat	329..352	CDD:275380	9/22 (41%)
		LRR_8	352..416	CDD:290566	9/63 (14%)
		leucine-rich repeat	353..376	CDD:275380	7/22 (32%)
		LRRCT	414..>450	CDD:214507	12/33 (36%)
lgi1	NP_001072366.1	leucine-rich repeat	66..87	CDD:275378	3/23 (13%)
		LRR_8	87..146	CDD:338972	22/58 (38%)
		leucine-rich repeat	88..111	CDD:275378	8/22 (36%)
		leucine-rich repeat	112..135	CDD:275378	9/22 (41%)
		leucine-rich repeat	136..159	CDD:275378	7/22 (32%)
		PCC	141..>216	CDD:188093	18/89 (20%)
		leucine-rich repeat	160..172	CDD:275378	3/40 (8%)
		EPTP	221..260	CDD:367630
		EPTP	267..305	CDD:367630
		EPTP	313..357	CDD:367630
		EPTP	362..402	CDD:367630
		EPTP	409..449	CDD:367630
		EPTP	455..494	CDD:367630
		EPTP	501..540	CDD:367630
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X486
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.000