DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Con and Cpn2

DIOPT Version :9

Sequence 1:	NP_001246635.1	Gene:	Con / 38590	FlyBaseID:	FBgn0005775	Length:	691	Species:	Drosophila melanogaster
Sequence 2:	NP_082180.2	Gene:	Cpn2 / 71756	MGIID:	1919006	Length:	547	Species:	Mus musculus

Alignment Length:	409	Identity:	104/409 - (25%)
Similarity:	164/409 - (40%)	Gaps:	60/409 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   104 DSTGFCTRRRDMKLMCYCTPDENHVPVQKAECWVFSE---------------GLHQNDTTWTRFY 153
            |:.|...|.:|:::        ...||......:||.               ||.::     .|.
Mouse    91 DAFGGLPRLQDLEI--------TGSPVSNLSAHIFSNLSSLEKLTLDFDRLAGLPED-----LFC 142

  Fly   154 QQKRLRELKFVIQNNARLDYIPTMIIEPLKNLSSIVIEYSQVEIVKSYAFANLPFLERIILNNNH 218
            ....|..|:  :|.| :|..:|..:.:.|::|.::.:..:.:..:...||.:|..|:.:.|:||.
Mouse   143 HMDILESLQ--LQGN-QLRTLPGRLFQSLRDLRTLNLAQNLLTQLPKGAFQSLTGLQMLKLSNNM 204

  Fly   219 IMALDQDAFANHIRLRELNLEHNQIFEMDRYAFRNLPLCERLFLNNNNISTLHEGLFADMARLTF 283
            :..|.:.|..:...|:||.|:.|.|.|:..:.|..|...|.|:|.:|.|..|...||:.:..|||
Mouse   205 LARLPEGALGSLSSLQELFLDGNAITELSPHLFSQLFSLEMLWLQHNAICHLPVSLFSSLHNLTF 269

  Fly   284 LNLAHNQINVLTSEIFRGLGNLNVLKLTRNNLNFIGDTVFAELWSLSELELDDNRIERISERALD 348
            |:|..|.:..|...:|.....|..|.|:.|.|..|.:..|..|..|..|.|..|.|..:.|....
Mouse   270 LSLKDNALRTLPEGLFAHNQGLLHLSLSYNQLETIPEGAFTNLSRLVSLTLSHNAITDLPEHVFR 334

  Fly   349 GLNTLKTLNLRNNLLKKIDNGLLRGTPALLSINVQANKLETLTFYTFQPIMDNLVNSTSELLVSD 413
            .|..|..|:|.:|.|..:...|......|..:|:..|:|.||....|....| |.|    |.:..
Mouse   335 NLEQLVKLSLDSNNLTALHPALFHNLSRLQLLNLSRNQLTTLPGGIFDTNYD-LFN----LALLG 394

  Fly   414 NKFICDCRLQWIFELKNRTRHLQL-RDSLEDLHCTLQEP-----------KLSHFVDPVPPTILD 466
            |.:.|||.|.::      |..|:| .:.:.:.|.....|           |....:.||.|..|
Mouse   395 NPWQCDCHLSYL------TSWLRLYNNQISNTHTFCAGPAYLKGQLVPNLKQEQLICPVNPGHL- 452

  Fly   467 VLNIGGFTAIGSNSASMGG 485
                 .|.|:|.:.....|
Mouse   453 -----SFRALGLDEGEPAG 466

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Con	NP_001246635.1	LRR_RI	<147..291	CDD:238064	41/143 (29%)
		LRR_8	183..243	CDD:290566	15/59 (25%)
		leucine-rich repeat	185..208	CDD:275380	4/22 (18%)
		leucine-rich repeat	209..232	CDD:275380	6/22 (27%)
		LRR_RI	<225..416	CDD:238064	59/190 (31%)
		LRR_8	232..291	CDD:290566	23/58 (40%)
		leucine-rich repeat	233..256	CDD:275380	9/22 (41%)
		leucine-rich repeat	257..280	CDD:275380	8/22 (36%)
		leucine-rich repeat	281..304	CDD:275380	8/22 (36%)
		LRR_8	304..363	CDD:290566	19/58 (33%)
		leucine-rich repeat	305..328	CDD:275380	8/22 (36%)
		leucine-rich repeat	329..352	CDD:275380	7/22 (32%)
		LRR_8	352..416	CDD:290566	18/63 (29%)
		leucine-rich repeat	353..376	CDD:275380	6/22 (27%)
		LRRCT	414..>450	CDD:214507	9/36 (25%)
Cpn2	NP_082180.2	LRRNT	21..52	CDD:214470
		LRR_8	73..133	CDD:290566	8/49 (16%)
		leucine-rich repeat	75..98	CDD:275380	2/6 (33%)
		LRR 1	98..119		5/28 (18%)
		leucine-rich repeat	99..122	CDD:275380	5/30 (17%)
		LRR_8	121..181	CDD:290566	11/67 (16%)
		LRR 2	122..143		3/25 (12%)
		leucine-rich repeat	123..146	CDD:275380	3/27 (11%)
		LRR 3	146..167		6/23 (26%)
		leucine-rich repeat	147..170	CDD:275380	7/25 (28%)
		LRR_RI	149..374	CDD:238064	65/227 (29%)
		LRR 4	170..191		3/20 (15%)
		LRR_8	171..229	CDD:290566	15/57 (26%)
		leucine-rich repeat	171..194	CDD:275380	4/22 (18%)
		LRR 5	194..215		6/20 (30%)
		leucine-rich repeat	195..218	CDD:275380	6/22 (27%)
		LRR_8	217..277	CDD:290566	23/59 (39%)
		LRR 6	218..239		8/20 (40%)
		leucine-rich repeat	219..242	CDD:275380	9/22 (41%)
		LRR 7	242..263		8/20 (40%)
		leucine-rich repeat	243..266	CDD:275380	8/22 (36%)
		LRR_8	266..325	CDD:290566	20/58 (34%)
		LRR 8	266..287		8/20 (40%)
		leucine-rich repeat	267..290	CDD:275380	8/22 (36%)
		LRR 9	290..311		7/20 (35%)
		leucine-rich repeat	291..314	CDD:275380	8/22 (36%)
		LRR_8	313..373	CDD:290566	16/59 (27%)
		LRR 10	314..335		6/20 (30%)
		leucine-rich repeat	315..338	CDD:275380	7/22 (32%)
		LRR 11	338..359		6/20 (30%)
		leucine-rich repeat	339..360	CDD:275380	6/20 (30%)
		LRR 12	362..383		7/20 (35%)
		leucine-rich repeat	363..382	CDD:275380	6/18 (33%)
		LRRCT	395..436	CDD:214507	10/46 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167831238
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.930