Protein Alignment Con and Lrrc4

DIOPT Version :10

• Sequence 1: NP_523930.3
• Gene: Con / 38590
• FlyBaseID: FBgn0005775
• Length: 691
• Species: Drosophila melanogaster
• Sequence 2: NP_001032413.1
• Gene: Lrrc4 / 641521
• RGDID: 1560026
• Length: 652
• Species: Rattus norvegicus
• Alignment Length: 309
• Identity: 76/309 - (24%)
• Similarity: 128/309 - (41%)
• Gaps: 47/309 - (15%)

  Fly   118 MCYCTPDENHVPVQKAECWVFSEGLHQNDTTWTRFYQQKRLRELKFVIQNNARLDYIPTMIIEPL 182
            :|.|:...:.|...:.......:|:..|    ||:..         :::||.::  |.......|
  Rat    48 VCSCSNQFSKVVCTRRGLSEVPQGIPSN----TRYLN---------LMENNIQM--IQADTFRHL 97

  Fly   183 KNLSSIVIEYSQVEIVKSYAFANLPFLERIILNNNHIMALDQDAFANHIRLRELNLEHNQIFEMD 247
            .:|..:.:..:.:..::..||..|..|..:.|.:|.:..:...||....:||||.|.:|.|..:.
  Rat    98 HHLEVLQLGRNAIRQIEVGAFNGLASLNTLELFDNWLTVIPSGAFEYLSKLRELWLRNNPIESIP 162

  Fly   248 RYAFRNLPLCERLFLNN-NNISTLHEGLFADMARLTFLNLAHNQINVLTSEIFRGLGNLNVLKLT 311
            .|||..:|...||.|.. ..:..:.||.|..:..|.:|||              |:.|:..:.
  Rat   163 SYAFNRVPSLMRLDLGELKKLEYISEGAFEGLFNLKYLNL--------------GMCNIKDMP-- 211

  Fly   312 RNNLNFIGDTVFAELWSLSELELDDNRIERISERALDGLNTLKTLNLRNNLLKKIDNGLLRGTPA 376
              ||        ..|..|.|||:..|....|...:..||::||.|.:.|:.:..|:.....|..:
  Rat   212 --NL--------TPLVGLEELEMSGNHFPEIRPGSFHGLSSLKKLWVMNSQVSLIERNAFDGLAS 266

  Fly   377 LLSINVQANKLETLTFYTFQPIMDNLVNSTSELLVSDNKFICDCRLQWI 425
            |:.:|:..|.|.:|....|.|:. .||    ||.:..|.:.|||.:.|:
  Rat   267 LVELNLAHNNLSSLPHDLFTPLR-YLV----ELHLHHNPWNCDCDILWL 310

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Con	NP_523930.3	LRR	<157..459	CDD:443914	69/270 (26%)
		leucine-rich repeat	185..208	CDD:275380	4/22 (18%)
		leucine-rich repeat	209..232	CDD:275380	5/22 (23%)
		leucine-rich repeat	233..256	CDD:275380	10/22 (45%)
		leucine-rich repeat	257..280	CDD:275380	6/23 (26%)
		leucine-rich repeat	281..304	CDD:275380	5/22 (23%)
		leucine-rich repeat	305..328	CDD:275380	3/22 (14%)
		leucine-rich repeat	329..352	CDD:275380	8/22 (36%)
		leucine-rich repeat	353..376	CDD:275380	6/22 (27%)
Lrrc4	NP_001032413.1	LRRNT	45..78	CDD:214470	6/33 (18%)
		LRR	<74..322	CDD:443914	72/283 (25%)
		LRR 1	75..96		6/35 (17%)
		leucine-rich repeat	76..99	CDD:275380	6/33 (18%)
		LRR 2	99..120		3/20 (15%)
		leucine-rich repeat	100..123	CDD:275380	4/22 (18%)
		LRR 3	123..144		5/20 (25%)
		leucine-rich repeat	124..147	CDD:275380	5/22 (23%)
		LRR 4	147..168		10/20 (50%)
		leucine-rich repeat	148..171	CDD:275380	10/22 (45%)
		LRR 5	171..193		6/21 (29%)
		leucine-rich repeat	172..196	CDD:275380	6/23 (26%)
		LRR 6	196..217		8/46 (17%)
		leucine-rich repeat	197..218	CDD:275380	9/46 (20%)
		LRR 7	218..239		6/20 (30%)
		leucine-rich repeat	219..242	CDD:275380	8/22 (36%)
		LRR 8	242..263		5/20 (25%)
		leucine-rich repeat	243..266	CDD:275380	6/22 (27%)
		LRR 9	266..287		6/20 (30%)
		leucine-rich repeat	267..288	CDD:275380	6/20 (30%)
		LRRCT	299..350	CDD:214507	5/12 (42%)
		IG_like	358..440	CDD:214653
		Ig strand B	369..373	CDD:409353
		Ig strand C	380..384	CDD:409353
		Ig strand E	406..410	CDD:409353
		Ig strand F	420..425	CDD:409353
		Ig strand G	433..436	CDD:409353